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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-10-2012 | Research Article

A multimodal imaging approach to the evaluation of post-traumatic epilepsy

Authors: Silvia F. Storti, Emanuela Formaggio, Enrica Franchini, Luigi G. Bongiovanni, Roberto Cerini, Antonio Fiaschi, Christoph M. Michel, Paolo Manganotti

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 5/2012

Abstract

Object

Electroencephalography-functional magnetic resonance imaging (EEG-fMRI) coregistration and high-density EEG (hdEEG) can be combined to map noninvasively abnormal brain activation elicited by epileptic processes. By combining noninvasive imaging techniques in a multimodal approach, we sought to investigate pathophysiological mechanisms underlying epileptic activity in seven patients with severe traumatic brain injury.

Materials and methods

Standard EEG and fMRI data were acquired during a single scanning session. The EEG-fMRI data were analyzed using the general linear model and independent component analysis. Source localization of interictal epileptiform discharges (IEDs) was performed using 256-channel hdEEG. Blood oxygenation level dependent (BOLD) localizations were then compared to EEG source reconstruction.

Results

On hdEEG, focal source localization was detected in all seven patients; in six out of seven it was concordant with the expected epileptic activity as defined by EEG data and clinical evaluation; and in four out of seven in whom IEDs were recorded, BOLD signal changes were observed. These activities were partially concordant with the source localization.

Conclusion

Multimodal integration of EEG-fMRI and hdEEG combining two different methods to localize the same epileptic foci appears to be a promising tool to noninvasively map abnormal brain activation in patients with post-traumatic brain injury.

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Title: A multimodal imaging approach to the evaluation of post-traumatic epilepsy
Authors: Silvia F. Storti
Emanuela Formaggio
Enrica Franchini
Luigi G. Bongiovanni
Roberto Cerini
Antonio Fiaschi
Christoph M. Michel
Paolo Manganotti
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 5/2012
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-012-0316-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A multimodal imaging approach to the evaluation of post-traumatic epilepsy

Abstract

Object

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Object

Materials and methods

Results

Conclusion

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