Skip to main content
Top
Published in: Clinical Autonomic Research 2/2017

01-04-2017 | Research Article

Health-related quality of life and suicide risk in postural tachycardia syndrome

Authors: Cathy L. Pederson, Jill Blettner Brook

Published in: Clinical Autonomic Research | Issue 2/2017

Login to get access

Abstract

Purpose

Postural tachycardia syndrome (POTS) is a disorder featured by orthostatic intolerance. The purpose of this study was to investigate the severity of quality of life issues in POTS patients.

Methods

Online surveys for health related quality of life, sleep quality, fatigue, pain, and suicidal ideation were completed by 624 POTS patients and 139 controls.

Results

People with POTS have significantly more days of poor physical health (p < 0.001), fewer days with good energy (p < 0.001), and significantly more days with activity limitations (p < 0.001) than controls. Pain severity was significantly higher for those with POTS (p < 0.001) while feelings of control over life was lower than controls (p < 0.001). Sleep quality and daytime fatigue were also significantly worse for those with POTS than controls (p < 0.001). Finally, those with POTS have a significantly higher risk of suicide compared with controls (p < 0.001).

Interpretation

The myriad of symptoms from which many POTS patients suffer is associated with a decreased quality of life. Nearly half of our sample with POTS was at high risk for suicide. More work needs to be done to determine the underlying issues surrounding suicide in POTS so that an appropriate treatment regimen can be developed.
Literature
1.
go back to reference Thieben MJ, Sandroni P, Sletten DM et al (2007) Postural orthostatic tachycardia syndrome: the Mayo Clinic experience. Mayo Clin Proc 82(3):308–313PubMedCrossRef Thieben MJ, Sandroni P, Sletten DM et al (2007) Postural orthostatic tachycardia syndrome: the Mayo Clinic experience. Mayo Clin Proc 82(3):308–313PubMedCrossRef
3.
go back to reference Ojha A, Chelimsky TC, Chelimsky G (2011) Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome. J Pediatr 158:119–122CrossRef Ojha A, Chelimsky TC, Chelimsky G (2011) Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome. J Pediatr 158:119–122CrossRef
4.
go back to reference Bagai K, Wakwe CI, Malow B et al (2013) Estimation of sleep disturbances using wrist actigraphy in patients with postural tachycardia syndrome. Auton Neurosci Basic Clin 177:260–265CrossRef Bagai K, Wakwe CI, Malow B et al (2013) Estimation of sleep disturbances using wrist actigraphy in patients with postural tachycardia syndrome. Auton Neurosci Basic Clin 177:260–265CrossRef
5.
go back to reference Rowe PC, Barron DF, Calkins H, Maumenee IH, Tong PY, Geraghty MT (1999) Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers–Danlos syndrome. J Pediatr 135(4):494–499PubMedCrossRef Rowe PC, Barron DF, Calkins H, Maumenee IH, Tong PY, Geraghty MT (1999) Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers–Danlos syndrome. J Pediatr 135(4):494–499PubMedCrossRef
6.
go back to reference Deb A, Morgenshtern K, Culbertson CJ, Wang LB, Hohler–DePold A (2015) A survey-based analysis of symptoms in patients with postural orthostatic tachycardia syndrome. Baylor Univ Med Cent Proc 28(2):157–159 Deb A, Morgenshtern K, Culbertson CJ, Wang LB, Hohler–DePold A (2015) A survey-based analysis of symptoms in patients with postural orthostatic tachycardia syndrome. Baylor Univ Med Cent Proc 28(2):157–159
7.
go back to reference Freitas J, Azevedo E, Santos R, Rocha-Goncalves F (2015) Autonomic activity and biomarker behavior in supine position and after passive postural stress in different orthostatic intolerance syndromes. Portuguese J Cardiol 34(9):543–549CrossRef Freitas J, Azevedo E, Santos R, Rocha-Goncalves F (2015) Autonomic activity and biomarker behavior in supine position and after passive postural stress in different orthostatic intolerance syndromes. Portuguese J Cardiol 34(9):543–549CrossRef
8.
go back to reference Benrud-Larson LM, Dewar MS, Sandroni P, Rummans TA, Haythornthwaite JA, Low PA (2002) Quality of life in patients with postural tachycardia syndrome. Mayo Clin Proc 77:531–537PubMedCrossRef Benrud-Larson LM, Dewar MS, Sandroni P, Rummans TA, Haythornthwaite JA, Low PA (2002) Quality of life in patients with postural tachycardia syndrome. Mayo Clin Proc 77:531–537PubMedCrossRef
9.
go back to reference Conner R, Sheikh M, Grubb B (2012) Postural orthostatic tachycardia syndrome (POTS): evaluation and management. Br J Med Pract 5(4):540 Conner R, Sheikh M, Grubb B (2012) Postural orthostatic tachycardia syndrome (POTS): evaluation and management. Br J Med Pract 5(4):540
10.
go back to reference Anderson JW, Lambert EA, Sari CI et al (2014) Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS). Front Physiol 5:1–9CrossRef Anderson JW, Lambert EA, Sari CI et al (2014) Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS). Front Physiol 5:1–9CrossRef
11.
go back to reference Bhatia R, Kizibash SJ, Ahrens S et al (2016) Outcomes of adolescent-onset postural orthostatic tachycardia syndrome. J Pediatr 173:149–153PubMedCrossRef Bhatia R, Kizibash SJ, Ahrens S et al (2016) Outcomes of adolescent-onset postural orthostatic tachycardia syndrome. J Pediatr 173:149–153PubMedCrossRef
12.
go back to reference Benrud-Larson LM, Sandroni P, Haythornthwaite JA, Rummans TA, Low PA (2003) Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings. Health Psychol 22(6):643–648PubMedCrossRef Benrud-Larson LM, Sandroni P, Haythornthwaite JA, Rummans TA, Low PA (2003) Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings. Health Psychol 22(6):643–648PubMedCrossRef
13.
go back to reference Moon J, Kim DY, Byun JI et al (2016) Orthostatic intolerance symptoms are associated with depression and diminished quality of life in patients with postural tachycardia syndrome. Health Qual Life Outcomes 14(1):144PubMedPubMedCentralCrossRef Moon J, Kim DY, Byun JI et al (2016) Orthostatic intolerance symptoms are associated with depression and diminished quality of life in patients with postural tachycardia syndrome. Health Qual Life Outcomes 14(1):144PubMedPubMedCentralCrossRef
14.
go back to reference Kavi L, Nuttall M, Low DA et al (2016) A profile of patients with postural tachycardia syndrome and their experience of healthcare in the UK. Br J Cardiol 23:33 Kavi L, Nuttall M, Low DA et al (2016) A profile of patients with postural tachycardia syndrome and their experience of healthcare in the UK. Br J Cardiol 23:33
15.
go back to reference Bagai K, Song Y, Ling JF et al (2011) Sleep disturbance and diminished quality of life in postural tachycardia syndrome. J Clin Sleep Med 7(2):204–210PubMedPubMedCentral Bagai K, Song Y, Ling JF et al (2011) Sleep disturbance and diminished quality of life in postural tachycardia syndrome. J Clin Sleep Med 7(2):204–210PubMedPubMedCentral
16.
go back to reference Center for Disease Control (2000) Measuring healthy days. Atlanta, CDC Center for Disease Control (2000) Measuring healthy days. Atlanta, CDC
17.
go back to reference Kerns RD, Turk DC, Rudy TE (1985) The west haven-yale multidimensional pain inventory (WHYMPI). Pain 23(4):345–356PubMedCrossRef Kerns RD, Turk DC, Rudy TE (1985) The west haven-yale multidimensional pain inventory (WHYMPI). Pain 23(4):345–356PubMedCrossRef
18.
go back to reference Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213PubMedCrossRef Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213PubMedCrossRef
19.
go back to reference Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46(10):1121–1123PubMedCrossRef Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46(10):1121–1123PubMedCrossRef
20.
go back to reference Miglis MG, Muppidi S, Feakins C, Fong L, Prieto T, Jaradeh S (2016) Sleep disorders in patients with postural tachycardia syndrome. Clin Auton Res 26(1):67–73PubMedCrossRef Miglis MG, Muppidi S, Feakins C, Fong L, Prieto T, Jaradeh S (2016) Sleep disorders in patients with postural tachycardia syndrome. Clin Auton Res 26(1):67–73PubMedCrossRef
21.
go back to reference Osman A, Bagge CL, Gutierrez PM, Konick LC, Kopper BA, Barrios FX (2001) The suicidal behaviors questionnaire-revised (SBQ-R): validation with clinical and nonclinical samples. Assessment 8(4):443–454PubMedCrossRef Osman A, Bagge CL, Gutierrez PM, Konick LC, Kopper BA, Barrios FX (2001) The suicidal behaviors questionnaire-revised (SBQ-R): validation with clinical and nonclinical samples. Assessment 8(4):443–454PubMedCrossRef
22.
go back to reference Kowal J, Wilson KG, McWilliams LA, Peloquin K, Duong D (2012) Self-perceived burden in chronic pain: relevance, prevalence, and predictors. Pain 153(8):1735–1741PubMedPubMedCentralCrossRef Kowal J, Wilson KG, McWilliams LA, Peloquin K, Duong D (2012) Self-perceived burden in chronic pain: relevance, prevalence, and predictors. Pain 153(8):1735–1741PubMedPubMedCentralCrossRef
23.
go back to reference Kanzler KE, Bryan CJ, McGeary DD, Morrow CE (2012) Suicidal ideation and perceived burdensomeness in patients with chronic pain. Pain Pract 12(8):602–609PubMedCrossRef Kanzler KE, Bryan CJ, McGeary DD, Morrow CE (2012) Suicidal ideation and perceived burdensomeness in patients with chronic pain. Pain Pract 12(8):602–609PubMedCrossRef
24.
go back to reference Xu X, Huang H, Sethi S, Zuzuarregui JRP, Weinberg J, Hohler AD (2016) A survey based study on sleep disturbance in postural tachycardia syndrome. J Neurol Sci 365:199–202PubMedCrossRef Xu X, Huang H, Sethi S, Zuzuarregui JRP, Weinberg J, Hohler AD (2016) A survey based study on sleep disturbance in postural tachycardia syndrome. J Neurol Sci 365:199–202PubMedCrossRef
25.
go back to reference Mallien J, Isenmann S, Mrazek A, Haensch C-A (2014) Sleep disturbances and autonomic dysfunction in patients with postural orthostatic tachycardia syndrome. Front Neurol 5:118–124PubMedPubMedCentralCrossRef Mallien J, Isenmann S, Mrazek A, Haensch C-A (2014) Sleep disturbances and autonomic dysfunction in patients with postural orthostatic tachycardia syndrome. Front Neurol 5:118–124PubMedPubMedCentralCrossRef
26.
go back to reference Cauwenbergh D, Nijs J, Kos D, Weijnen L, Struyf F, Meeus M (2014) Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review. Eur J Clin Invest 44(5):516–526PubMedCrossRef Cauwenbergh D, Nijs J, Kos D, Weijnen L, Struyf F, Meeus M (2014) Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review. Eur J Clin Invest 44(5):516–526PubMedCrossRef
27.
go back to reference Hoad A, Spickett G, Elliott J, Newton J (2008) Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome. Int J Med 101(12):961–965 Hoad A, Spickett G, Elliott J, Newton J (2008) Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome. Int J Med 101(12):961–965
28.
go back to reference Jarjour IT (2013) Postural tachycardia syndrome in children and adolescents. Semin Pediatr Neurol 20(1):18–26PubMedCrossRef Jarjour IT (2013) Postural tachycardia syndrome in children and adolescents. Semin Pediatr Neurol 20(1):18–26PubMedCrossRef
29.
go back to reference Johnson JN, Mack KJ, Kuntz NL, Brands CK, Porter CJ, Fischer PR (2010) Postural orthostatic tachycardia syndrome: a clinical review. Pediatr Neurol 42(2):77–85PubMedCrossRef Johnson JN, Mack KJ, Kuntz NL, Brands CK, Porter CJ, Fischer PR (2010) Postural orthostatic tachycardia syndrome: a clinical review. Pediatr Neurol 42(2):77–85PubMedCrossRef
30.
go back to reference Khurana RK (2014) Visceral sensitization in postural tachycardia syndrome. Clin Auton Res 24(2):71–76PubMedCrossRef Khurana RK (2014) Visceral sensitization in postural tachycardia syndrome. Clin Auton Res 24(2):71–76PubMedCrossRef
31.
go back to reference Breivik H, Reme SE, Linton SJ (2014) High risk of depression and suicide attempt among chronic pain patients: always explore catastrophizing and suicide thoughts when evaluating chronic pain patients. Scand J Pain 5(1):1–3CrossRef Breivik H, Reme SE, Linton SJ (2014) High risk of depression and suicide attempt among chronic pain patients: always explore catastrophizing and suicide thoughts when evaluating chronic pain patients. Scand J Pain 5(1):1–3CrossRef
32.
go back to reference Calata R, Laglaoui Bakhiyi C, Artero S, Ilgen M, Courtet P (2015) The impact of physical pain on suicidal thoughts and behaviors: meta-analyses. J Psychiatr Res 71:16–32CrossRef Calata R, Laglaoui Bakhiyi C, Artero S, Ilgen M, Courtet P (2015) The impact of physical pain on suicidal thoughts and behaviors: meta-analyses. J Psychiatr Res 71:16–32CrossRef
33.
go back to reference Bernert R, Kim JS, Iwata NG, Perlis ML (2015) Sleep disturbances as an evidence-based suicide risk factor. Curr Psychiatry Rep 17(3):15–24CrossRef Bernert R, Kim JS, Iwata NG, Perlis ML (2015) Sleep disturbances as an evidence-based suicide risk factor. Curr Psychiatry Rep 17(3):15–24CrossRef
34.
go back to reference Ribeiro JD, Pease JL, Gutierrez PM et al (2012) Sleep problems outperform depression and hopelessness as cross-sectional and longitudinal predictors of suicidal ideation and behavior in young adults in the military. J Affect Disord 136(3):743–750PubMedCrossRef Ribeiro JD, Pease JL, Gutierrez PM et al (2012) Sleep problems outperform depression and hopelessness as cross-sectional and longitudinal predictors of suicidal ideation and behavior in young adults in the military. J Affect Disord 136(3):743–750PubMedCrossRef
Metadata
Title
Health-related quality of life and suicide risk in postural tachycardia syndrome
Authors
Cathy L. Pederson
Jill Blettner Brook
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 2/2017
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-017-0399-5

Other articles of this Issue 2/2017

Clinical Autonomic Research 2/2017 Go to the issue