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Clinical Autonomic Research
Published in: Clinical Autonomic Research 6/2007

01-12-2007 | RESEARCH ARTICLE

Exercise training improves cardiovascular and autonomic profiles in HIV

Authors: David K. Spierer, EdD, Ronald E. DeMeersman, PhD, Jay Kleinfeld, MD, Eugene McPherson, MD, Robert E. Fullilove, PhD, Augusta Alba, MD, Adrienne S. Zion, PhD

Published in: Clinical Autonomic Research | Issue 6/2007

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Abstract

Objectives

Human immunodeficiency virus (HIV) is associated with cardiovascular (CV) and autonomic dysfunction, however the effects of fitness on vascular and autonomic mechanisms in HIV disease are unknown.

Methods

We studied forty-eight subjects (40.4 ± 4.2 years) in a cross-sectional design matched for age, gender, BMI, and fitness. Participants were assigned to 1 in 4 groups: 1) Healthy Unfit (HU), 2) Healthy Fit (HF), 3) HIV Positive Unfit (HPU), and 4) HIV Positive Fit (HPF). Fitness was assessed via open-circuit spirometry; arterial compliance and autonomic modulations were measured via applanation tonometry and power spectral analysis, respectively, and baroreflex sensitivity was obtained using the alpha index.

Results

Arterial compliance was augmented in HPF vs. HPU [7.4 ± 1.9 mmHg × second vs. 4.4 ± 1.7 mmHg × second (P = 0.006)]. Parasympathetic modulation was higher in HPF vs. HPU [2244.5 ± 2997.6 msecond2 vs. 489.1 ± 552.9 msecond2 (P < 0.05)]. Sympathetic modulation was lower in HPF vs. HU [4.7 ± 5.0 mmHg2 vs. 12.9 ± 9.7 mmHg2 (P < 0.05)]. Baroreflex sensitivity was higher in HPF vs. HPU [17.3 ± 10.2 msecond/mmHg vs. 7.4 ± 3.8 msecond/mmHg (P = 0.003)], and HPF vs. HU [17.3 ± 10.2 msecond/mmHg vs. 6.2 ± 3.0 msecond/mmHg (P = 0.004)].

Conclusions

Augmentations in arterial compliance and baroreflex sensitivity associated with fitness portent an improved CV and autonomic profile for HIV-positive individuals. Physical activity may be an adjuvant method to enhance the overall vascular health in HIV-compromised individuals.
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Metadata
Title
Exercise training improves cardiovascular and autonomic profiles in HIV
Authors
David K. Spierer, EdD
Ronald E. DeMeersman, PhD
Jay Kleinfeld, MD
Eugene McPherson, MD
Robert E. Fullilove, PhD
Augusta Alba, MD
Adrienne S. Zion, PhD
Publication date
01-12-2007
Publisher
D. Steinkopff-Verlag
Published in
Clinical Autonomic Research / Issue 6/2007
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-007-0441-0

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