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Odontology
Published in: Odontology 1/2019

01-01-2019 | Original Article

Association between periodontitis and chronic migraine: a case–control study

Authors: Pablo Ameijeira, Yago Leira, Clara Domínguez, Rogelio Leira, Juan Blanco

Published in: Odontology | Issue 1/2019

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Abstract

The aim of this investigation was to examine whether chronic periodontitis (CP) is a risk indicator of chronic migraine (CM). We performed a case–control study consisted of 102 cases (patients diagnosed with CM) and 91 controls (non-CM individuals) matched by age and gender. Full-mouth periodontal charts, demographic, medical, clinical, as well as neurological data were obtained. In addition, high sensitive C-reactive protein serum levels were determined from blood samples of both cases (taken during migraine interictal period) and controls. The prevalence of CP was significantly higher in patients with CM compared to those without CM (58.8 vs. 30.8%, p < 0.0001). Logistic regression analysis showed that CP was significantly associated with the presence of CM, independently of well-known chronifying factors of migraine (OR 2.4; 95% CI 1.2–4.7; p = 0.012). Based on our results, CP could be considered as a risk indicator of CM. However, more evidence is necessary to investigate if this relationship is causal or not.
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Metadata
Title
Association between periodontitis and chronic migraine: a case–control study
Authors
Pablo Ameijeira
Yago Leira
Clara Domínguez
Rogelio Leira
Juan Blanco
Publication date
01-01-2019
Publisher
Springer Japan
Published in
Odontology / Issue 1/2019
Print ISSN: 1618-1247
Electronic ISSN: 1618-1255
DOI
https://doi.org/10.1007/s10266-018-0360-7

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