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Odontology
Published in: Odontology 2/2011

01-07-2011 | Case Report

Radiation-induced malignant fibrous histiocytoma of the maxilla

Authors: Takafumi Satomi, Masato Watanabe, Tadayoshi Kaneko, Jun Matsubayashi, Toshitaka Nagao, Hiroshige Chiba

Published in: Odontology | Issue 2/2011

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Abstract

Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual histiocytic and fibroblastic differentiation. We report on an MFH of the left maxilla that developed in a 79-year old woman 20 years after surgery and radiation for squamous cell carcinoma (SCC). Postoperative radiotherapy with 70 Gy was administered for a primary neoplasm of SCC of the left maxilla to a localized field through two lateral ports. This secondary neoplasm arose at the site of tumor resection (partial maxillectomy) within the irradiated field, and was resected. The development of sarcomas is a recognized complication of radiation therapy. The final diagnosis after the operation was MFH. The patient died of tumor recurrence at the skull base and within the cranium, 19 months after the operation. Radiation-induced sarcoma is well known, but radiation-induced MFH is relatively rare in the head and neck region. The details of this case are presented with a review of literature.
Literature
1.
2.
Bentz BG, Singh B, Woodruff J, Brennan M, Shah JP, Kraus D. Head and neck soft tissue sarcomas: a multivariate analysis of outcomes. Ann Surg Oncol. 2004;11:619–28.PubMedCrossRef
3.
Dudhat SB, Mistry RC, Varughese T, Fakih AR, Chinoy RF. Prognostic factors in head and neck soft tissue sarcoma. Cancer. 2000;89:868–72.PubMedCrossRef
4.
Sheppard DG, Libshitz HI. Post-radiation sarcoma: a review of the clinical and imaging features in 63 cases. Clin Radiol. 2001;56:22–9.PubMedCrossRef
5.
Makimoto Y, Yamamoto S, Takano H, Motoori K, Ueda T, Kazama T, Kaneoya K, Shimofusa R, Uno T, Ito H, Hanazawa T, Okamoto Y, Hayasaki K. Imaging findings of radiation-induced sarcoma of the head and neck. Br J Radiol. 2007;80:790–7.PubMedCrossRef
6.
Gibbs JF, Huang PP, Lee RJ, McGrath B, Brooks J, Mckinley B, Driscoll D, Kraybill WG. Malignant fibrous histiocytoma: an institutional review. Cancer Invest. 2001;19:23–7.PubMedCrossRef
7.
Sabesan T, Xuexi W, Yongfa Q, Pingzhang T, Ilankovan V. Malignant fibrous histiocytoma: outcome of tumours in the head and neck compared with those in the trunk and extremities. Br J Oral Maxillofac Surg. 2006;44:209–12.PubMedCrossRef
8.
Wang CP, Chang YL, Ting LL, Yang TL, Ko JY, Lou PJ. Malignant fibrous histiocytoma of the sinonasal tract. Head Neck. 2009;31:85–93.PubMedCrossRef
9.
Al-Agha OM, Igbokwe AA. Malignant fibrous histiocytoma. between the past and present. Arch Pathol Lab Med. 2008;132:1030–5.PubMed
10.
Cassidy M, Loftus B, Whelan A, Sabt B, Hickey D, Henry K, Leader M. KP-1: not a specific marker: Staining of 137 sarcoma, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes. Virchows Arch. 1994;424:635–40.PubMedCrossRef
11.
Leader M, Patel J, Collins M, Henry K. Anti-alpha 1-antichymotrypsin staining of 194 sarcomas, 38 carcinomas, and 17 malignant melanomas: its lack of specificity as a tumour marker. Am J Surg Pathol. 1987;2:133–9.
12.
Szollosi Z, Nemeth T, Egervari K, Nemes Z. Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma. Pathol Res Pract. 2005; 5:369–7.
13.
Cahan WG, Woodward HQ, Higinbotham NL, Stewart FW, Coley BL. Sarcoma arising in irradiated bone: report of eleven cases. Cancer. 1948;1:3–29.PubMedCrossRef
14.
Robinson E, Neugut AI, Wylie P. Clinical aspects of postirradiation sarcomas. J Natl Cancer Inst. 1988;80:233–40.PubMedCrossRef
15.
Laskin WB, Silverman TA, Enzinger FM. Postradiation soft tissue sarcoma: an analysis of 53 cases. Cancer. 1988;62:2330–40.PubMedCrossRef
16.
Patel SG, See AC, Williamson PA, Archer DJ, RhysEvans PH. Radiation-induced sarcoma of the head and neck. Head Neck. 1999;21:346–54.PubMedCrossRef
17.
Davidson T, Westbury G, Harmer CL. Radiation-induced soft-tissue sarcoma. Br J Surg. 1986;73:308–9.PubMedCrossRef
18.
Kirova YM, Vilcoq JR, Asselain B, Sastre-Garau X, Fourquet A. Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review. Cancer. 2005;104:856–63.PubMedCrossRef
19.
Karlsson P, Holmberg E, Samuelsson A, Johansson KA, Wallgren A. A soft tissue sarcoma after treatment for breast cancer—a Swedish population-based study. Eur J Cancer. 1998;34:2068–75.PubMedCrossRef
20.
Killion MJ, Brodovsky HS, Schwarting R. Pericardial angiosarcoma after mediastinal irradiation for seminoma. A case report and a review of the literature. Cancer. 1996;78:912–7.PubMedCrossRef
21.
Arlen M, Higinbotham NL, Huvos AG, Marcove RC, Miller T, Shah IC. Radiation-induced sarcoma of bone. Cancer. 1971;28:1087–99.PubMedCrossRef
22.
Kim JK, Chu FC, Woodward HQ, Huvos A. A radiation-induced sarcoma of bone following therapeutic radiation. Int J Radiat Oncol Biol Phys. 1983;9:107–10.PubMedCrossRef
23.
Pitcher ME, Davidson TI, Fisher C, Meirion Thomas J. Post-irradiation sarcoma of soft tissue and bone. Euro J Surg Oncol. 1994;20:53–6.
24.
Wiklund TA, Blomqvist CP, Raty J, Elomaa I, Rissanen P, Miettinen M. Postirradiation sarcoma: Analysis of a nationwide cancer registry material. Cancer. 1991;68:524–31.PubMedCrossRef
25.
Wanebo HJ, Koness RJ, MacFarlane JK, Eilber FR, Byers RM, Elias EG, Spiro RH. Head and neck sarcoma: report of the Head and Neck Sarcoma Registry. Society of Head and Neck Surgeons Committee on Research. Head Neck. 1992;14:1–7.PubMedCrossRef
26.
Lagrange JL, Ramaioli A, Chateau MC, Marchal C, Resbeut M, Richaud P, Lagarde P, Rambert P, Tortechaux J, Seng SH, de la Fontan B, Reme-Saumon M, Bof J, Ghnassia JP, Coindre JM. Sarcoma after radiation therapy: retrospective multiinstitutional study of 80 histologically confirmed cases. Radiation therapist and Pathologist groups of the Federation nationale des centres de lutte contre le cancer. Radiology. 2000;216:197–205.PubMed
27.
Mark RJ, Bailet JW, Poen JC, Tran LM, Calcaterra TC, Abemayor E, Fu YS, Parker RG. Postirradiation sarcoma of the head and neck. Cancer. 1993;72:887–93.PubMedCrossRef
28.
Patel SG, Shaha AR, Shah JP. Soft tissue sarcomas of the head and neck: an update. Am J Otolaryngol. 2001;22:2–18.PubMedCrossRef
29.
Ohno T, Sakurai H, Saito Y, Takahashi M, Fukusato T, Mitsuhashi N, Niibe H. Secondary malignant fibrous histiocytoma following radiation therapy for carcinoma of the uterine cervix: report of two cases. Radiat Med. 1997;15:229–33.PubMed
30.
Ettinger LJ, Douglass HO, Higby DJ. Adjuvant adriamycin and cis-diamminedichloroplatinum (cis-platinum) in primary osteosarcoma. Cancer. 1981;47:248–54.PubMedCrossRef
31.
Hugate RR, Wilkins RM, Kelly CM, Madsen W, Hinshaw I, Camozzi AB. Intraarterial chemotherapy for extremity osteosarcoma and MFH in adults. Clin Orthop Relat Res. 2008;466:1292–301.PubMedCrossRef
32.
Ko JY, Chen CL, Lui LT, Hsu MM. Radiation-induced malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 1996;122:535–8.PubMed
33.
Haberal I, Samim E, Müzeyyen A, Özeri C. Radiation-induced malignant fibrous histiocytoma of the neck in a patient with laryngeal carcinoma. Am J Otolaryngol. 2001;22:146–9.PubMedCrossRef
34.
Sadati KS, Haber M, Sataloff RT. Malignant fibrous histiocytoma of the head and neck after radiation for squamous cell carcinoma. Ear Nose Throat J. 2004;83:278–81.PubMed
35.
Sadri D, Yazdi I. Postradiation malignant fibrous histiocytoma of the maxillary sinus. Arch Iran Med. 2007;10:393–6.PubMed
Metadata
Title
Radiation-induced malignant fibrous histiocytoma of the maxilla
Authors
Takafumi Satomi
Masato Watanabe
Tadayoshi Kaneko
Jun Matsubayashi
Toshitaka Nagao
Hiroshige Chiba
Publication date
01-07-2011
Publisher
Springer Japan
Published in
Odontology / Issue 2/2011
Print ISSN: 1618-1247
Electronic ISSN: 1618-1255
DOI
https://doi.org/10.1007/s10266-011-0001-x

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