Skip to main content
Top
Published in: Journal of Cutaneous Medicine and Surgery 3/2003

01-07-2003 | Case Report

Facial Lipoatrophy Following Systemic Lupus Erythematosus

Authors: Audrey Dupéré, Yves Poulin

Published in: Journal of Cutaneous Medicine and Surgery | Issue 3/2003

Login to get access

Abstract

Background: Acquired partial lipodystrophy is a rare disorder. An association with systemic lupus erythematosus has been reported. In these cases, an immunologic basis is suggested by the presence of C3 nephritic factor and hypocomplementemia. Objective: The following report presents the case of a woman who developed a rapid loss of facial subcutaneous fat a few months after complete spontaneous resolution of cutaneous lesions of lupus. Conclusion: Absence of C3NeF in this case suggests that other immunological factors may be involved in the pathogenesis.
Literature
1.
go back to reference Black, MM, Cunliffe, WJ 1998Lipodystrophy.Rook, AWilkinson, DSEbling, FJG eds. Textbook of Dermatology, 6th edBlackwell ScienceOxford24262431 Black, MM, Cunliffe, WJ 1998Lipodystrophy.Rook, AWilkinson, DSEbling, FJG eds. Textbook of Dermatology, 6th edBlackwell ScienceOxford24262431
2.
go back to reference Garg, A 2000Lipodystrophies.Am J Med108143152 Garg, A 2000Lipodystrophies.Am J Med108143152
3.
go back to reference Font, J, Herrero, C, Bosch, X, et al. 1990Systemic lupus erythemetosus in a patient with lipodystrophy.J Am Acad Dermatol22337340PubMed Font, J, Herrero, C, Bosch, X,  et al. 1990Systemic lupus erythemetosus in a patient with lipodystrophy.J Am Acad Dermatol22337340PubMed
4.
go back to reference Simpson, NB, Cunliffe, WJ, Davison, AM 1979Partial lipodystrophy, glomerulonephritis and hypocomplementaemia.Br J Dermatol1011112 Simpson, NB, Cunliffe, WJ, Davison, AM 1979Partial lipodystrophy, glomerulonephritis and hypocomplementaemia.Br J Dermatol1011112
5.
go back to reference Jasin, HE 1979Systemic lupus erythematosus, partial lipodystrophy and hypocomplementemia.J Rheumatol64350PubMed Jasin, HE 1979Systemic lupus erythematosus, partial lipodystrophy and hypocomplementemia.J Rheumatol64350PubMed
6.
go back to reference Walport, MJ, Davies, KA, Botto, M, et al. 1994C3 nephritic factor and SLE: report of four cases and review of the literature.Q J Med87609615 Walport, MJ, Davies, KA, Botto, M,  et al. 1994C3 nephritic factor and SLE: report of four cases and review of the literature.Q J Med87609615
7.
go back to reference Cronin, CC, Higgins, T, Molloy, M 1995Lupus, C3 nephritic factor and partial lipodystrophy.Q J Med88298299 Cronin, CC, Higgins, T, Molloy, M 1995Lupus, C3 nephritic factor and partial lipodystrophy.Q J Med88298299
8.
go back to reference Chartier, S, Buzzanga, JB, Paquin, F 1987Partial lipodystrophy associated with a type 3 form of membranoproliferative glomerulonephritis.J Am Acad Dermatol16201205PubMed Chartier, S, Buzzanga, JB, Paquin, F 1987Partial lipodystrophy associated with a type 3 form of membranoproliferative glomerulonephritis.J Am Acad Dermatol16201205PubMed
9.
go back to reference Gürbüz, O, Yücelten, D, Ergun, T, et al. 1995Partial lipodystrophy.Int J Dermatol343637PubMed Gürbüz, O, Yücelten, D, Ergun, T,  et al. 1995Partial lipodystrophy.Int J Dermatol343637PubMed
10.
go back to reference Daha, MR, Fearon, DT, Austen, KF 1976C3 nephritic factor (C3NeF): stabilization of fluid phase and cell-bound alternative pathway convertase.J Immunol11617PubMed Daha, MR, Fearon, DT, Austen, KF 1976C3 nephritic factor (C3NeF): stabilization of fluid phase and cell-bound alternative pathway convertase.J Immunol11617PubMed
11.
go back to reference Wayte, J, Bird, G, Wilkinson, JD 1996The clinical significance of partial lipoatrophy and C3 hypocomplementaemia: a report of two cases.Clin Exp Dermatol21131134CrossRefPubMed Wayte, J, Bird, G, Wilkinson, JD 1996The clinical significance of partial lipoatrophy and C3 hypocomplementaemia: a report of two cases.Clin Exp Dermatol21131134CrossRefPubMed
12.
go back to reference Porter, WM, O’Gorman–Lalor, O, Lane, RJM, et al. 2000Barraquer–Simons lipodystrophy, Raynaud’s phenomenom and cutaneous vasculitis.Clin Exp Dermatol25277280CrossRefPubMed Porter, WM, O’Gorman–Lalor, O, Lane, RJM,  et al. 2000Barraquer–Simons lipodystrophy, Raynaud’s phenomenom and cutaneous vasculitis.Clin Exp Dermatol25277280CrossRefPubMed
13.
go back to reference Commens, C, O’Neill, P, Walker, G 1990Dermatomyositis associated with multifocal lipoatrophy.J Am Acad Dermatol22966969PubMed Commens, C, O’Neill, P, Walker, G 1990Dermatomyositis associated with multifocal lipoatrophy.J Am Acad Dermatol22966969PubMed
14.
go back to reference Torrelo, A, Espana, A, Boixeda, P, et al. 1991Partial lipodystrophy and dermatomyositis.Arch Dermatol12718461847CrossRefPubMed Torrelo, A, Espana, A, Boixeda, P,  et al. 1991Partial lipodystrophy and dermatomyositis.Arch Dermatol12718461847CrossRefPubMed
15.
go back to reference Kavanagh, GM, Colaco, B, Kennedy, CTC 1993Juvenile dermatomyositis associated with partial lipoatrophy.J Am Acad Dermatol28348351PubMed Kavanagh, GM, Colaco, B, Kennedy, CTC 1993Juvenile dermatomyositis associated with partial lipoatrophy.J Am Acad Dermatol28348351PubMed
16.
go back to reference Huemer, C, Kitson, H, Malleson, PN, et al. 2001Lipodystrophy in patients with juvenile dermatomyositis–evaluation of clinical and metabolic abnormalities.J Rheumatol28610615PubMed Huemer, C, Kitson, H, Malleson, PN,  et al. 2001Lipodystrophy in patients with juvenile dermatomyositis–evaluation of clinical and metabolic abnormalities.J Rheumatol28610615PubMed
17.
go back to reference Pujol, RM, Domingo, P, Guiu, XM, et al. 2000HIV-1 protease inhibitor-associated partial lipodystrophy: clinicopathologic review of 14 cases.J Am Acad Dermatol42193198PubMed Pujol, RM, Domingo, P, Guiu, XM,  et al. 2000HIV-1 protease inhibitor-associated partial lipodystrophy: clinicopathologic review of 14 cases.J Am Acad Dermatol42193198PubMed
18.
go back to reference Perrot, H 1988Les lipoatrophies localisées.Ann Dermatol Venereol115523527PubMed Perrot, H 1988Les lipoatrophies localisées.Ann Dermatol Venereol115523527PubMed
19.
go back to reference Tan, EM, Cohen, AS, Fries, JF, et al. 1982The 1982 revised criteria for the classification of systemic lupus erythematosus.Arthritis Rheum2512711277PubMed Tan, EM, Cohen, AS, Fries, JF,  et al. 1982The 1982 revised criteria for the classification of systemic lupus erythematosus.Arthritis Rheum2512711277PubMed
20.
go back to reference Mathieson, PW, Wurzner, R, Oliveira, DBG, et al. 1993Complement-mediated adipocyte lysis by nephritic factor sera.J Exp Med17718271831PubMed Mathieson, PW, Wurzner, R, Oliveira, DBG,  et al. 1993Complement-mediated adipocyte lysis by nephritic factor sera.J Exp Med17718271831PubMed
21.
go back to reference Ledru, E, Christeff, N, Patey, O, et al. 2000Alteration of tumor necrosis factor-alpha T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome.Blood9531913198PubMed Ledru, E, Christeff, N, Patey, O,  et al. 2000Alteration of tumor necrosis factor-alpha T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome.Blood9531913198PubMed
22.
go back to reference Mynarcik, DC, McNurlan, MA, Steigbigel, RT, et al. 2000Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy.J Acquir Immune Defic Syndr25312321CrossRefPubMed Mynarcik, DC, McNurlan, MA, Steigbigel, RT,  et al. 2000Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy.J Acquir Immune Defic Syndr25312321CrossRefPubMed
23.
go back to reference Pachman, LM, Liotta–Davis, MR, Hong, DK, et al. 2000TNFalpha-308A allele in juvenile dermatomyositis: association with increased production of tumor necrosis factor alpha, disease duration, and pathologic calcifications.Arthritis Rheum4323682377CrossRefPubMed Pachman, LM, Liotta–Davis, MR, Hong, DK,  et al. 2000TNFalpha-308A allele in juvenile dermatomyositis: association with increased production of tumor necrosis factor alpha, disease duration, and pathologic calcifications.Arthritis Rheum4323682377CrossRefPubMed
24.
go back to reference Ducours, JL, Poizac, P, Ardanza, B, et al. 1991Barraquer–Simons syndrome and facial lipo-filling. A propos of a case.Rev Stomatol Chir Maxiliofac92105111 Ducours, JL, Poizac, P, Ardanza, B,  et al. 1991Barraquer–Simons syndrome and facial lipo-filling. A propos of a case.Rev Stomatol Chir Maxiliofac92105111
25.
26.
go back to reference Oral, EA, Simha, V, Ruiz, E, et al. 2002Leptin-replacement therapy for lipodystrophy.N EngI J Med346570578CrossRef Oral, EA, Simha, V, Ruiz, E,  et al. 2002Leptin-replacement therapy for lipodystrophy.N EngI J Med346570578CrossRef
Metadata
Title
Facial Lipoatrophy Following Systemic Lupus Erythematosus
Authors
Audrey Dupéré
Yves Poulin
Publication date
01-07-2003
Publisher
Springer-Verlag
Published in
Journal of Cutaneous Medicine and Surgery / Issue 3/2003
Print ISSN: 1203-4754
Electronic ISSN: 1615-7109
DOI
https://doi.org/10.1007/s10227-002-0159-5

Other articles of this Issue 3/2003

Journal of Cutaneous Medicine and Surgery 3/2003 Go to the issue

The World Literature

7. Surgery and Laser

The World Literature

3. Pediatric Dermatology