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Journal of Cutaneous Medicine and Surgery

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01-07-2003 | Basic/Clinical Science

Modulation of the Contact Hypersensitivity Response by Æ-941 (Neovastat), a Novel Antiangiogenic Agent

Authors: É. Dupont, B. Wang, A. J. Mamelak, B. G. Howell, G. Shivji, L. Zhuang, V. Dimitriadou, P. Falardeau, D. N. Sauder

Published in: Journal of Cutaneous Medicine and Surgery | Issue 3/2003

Abstract

Background: Æ-941 (Neovastat) is an angiogenesis inhibitor noted to have antiinflammatory properties. Objective: We tested Neovastat in a contact hypersensitivity (CHS) model to determine the mechanism of action of its antiinflammatory effects. Methods: Neovastat was orally administered (200 mg/kg/day) during the sensitization and challenge phases of a murine CHS assay and inflammatory responses were measured. Subsequent assays were performed on mice treated with Neovastat or Cortisone (120 mg/kg/day, IP) and differential mRNA expression of several pro- and antiinflammatory cytokines was quantified using RT-PCR. Results: Neovastat decreased inflammation by 39% when administered during sensitization but did not alter the CHS response when given during the challenge phase. Neovastat significantly induced IL-10 expression in skin and skin-draining lymph nodes (49% and 45%, respectively) and decreased IFNγ expression in the lymph nodes (35%). Conclusion: Antiinflammatory effects of Neovastat observed in CHS could be linked to modulation of cytokines early in the sensitization phase.

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Title: Modulation of the Contact Hypersensitivity Response by Æ-941 (Neovastat), a Novel Antiangiogenic Agent
Authors: É. Dupont
B. Wang
A. J. Mamelak
B. G. Howell
G. Shivji
L. Zhuang
V. Dimitriadou
P. Falardeau
D. N. Sauder
Publication date: 01-07-2003
Publisher: Springer-Verlag
Published in: Journal of Cutaneous Medicine and Surgery / Issue 3/2003
Print ISSN: 1203-4754
Electronic ISSN: 1615-7109
DOI: https://doi.org/10.1007/s10227-002-0120-7

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Springer Medicine

Modulation of the Contact Hypersensitivity Response by Æ-941 (Neovastat), a Novel Antiangiogenic Agent

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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