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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 2/2009

Open Access 01-04-2009 | Original

Polymorphism in apolipoprotein E among migraineurs and tension-type headache subjects

Authors: Ravi Gupta, Vivek Kumar, Kalpana Luthra, Basudeb Banerjee, Manjeet Singh Bhatia

Published in: The Journal of Headache and Pain | Issue 2/2009

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Abstract

Nitric oxide plays an important role in the pathogenesis of migraine as well as tension-type headache. Studies suggest that the expression of molecules involved in the pathogenesis of headache, i.e., nitric oxide and interleukin, is influenced by apolipoprotein E (APOE) and is gene specific. Hence, we hypothesized that APOE polymorphism may be associated with migraine as well as tension-type headache.The study sample comprised of three groups: migraineurs, tension-type headache subjects as well as a healthy control group. A total of 50 subjects in each group were included after screening for the inclusion and exclusion criteria. None of the subjects was a blood relative of any other subject included in the present study. Their venous blood was drawn and stored at −20°C. Genomic DNA extraction was performed with a commercial kit and simple sequence-specific primer PCR was performed to assess the APOE polymorphism. Data were analyzed with the help of SPSS V11.0 for Windows. χ2 test and logistic regression analysis were run. The results of the study showed that APOE ε2 gene increases the risk of migraine as compared to the control group and the tension-type headache group (OR = 4.85; 95% CI = 1.92–12.72; P < 0.001 and OR = 2.31; 95% CI = 1.08–4.94; P = 0.01, respectively). Interestingly, APOE ε4 gene was protective against migraine as well as tension-type headache. This study shows that APOE ε2 gene increases the risk of migraine, while APOE ε4 gene is protective against migraine and tension-type headache. Further research is required to confirm the findings of the present study in a larger sample and to elucidate the role of APOE polymorphism in headache.
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Metadata
Title
Polymorphism in apolipoprotein E among migraineurs and tension-type headache subjects
Authors
Ravi Gupta
Vivek Kumar
Kalpana Luthra
Basudeb Banerjee
Manjeet Singh Bhatia
Publication date
01-04-2009
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 2/2009
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-008-0094-y

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