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Modern Rheumatology

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01-11-2013 | Original Article

Expression of CD44 in articular cartilage is associated with disease severity in knee osteoarthritis

Authors: Fang-Jie Zhang, Wei Luo, Shu-Guang Gao, Da-Zhi Su, Yu-Sheng Li, Chao Zeng, Guang-Hua Lei

Published in: Modern Rheumatology | Issue 6/2013

Abstract

Objectives

To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease.

Methods

All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild lesions, moderate lesions and severe lesions. CD44 levels in articular cartilage were assessed by immunohistochemical methods.

Results

CD44 levels were detected in all four groups. The difference in average gray value of CD44 expression showed statistical significance when compared between each group (P < 0.05). In addition, CD44 expression in each group correlated with disease severity, according to the modified Mankin score (ρ = −0.848, P < 0.01).

Conclusions

CD44 in articular cartilage is associated with progressive knee OA joint damage.

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Title: Expression of CD44 in articular cartilage is associated with disease severity in knee osteoarthritis
Authors: Fang-Jie Zhang
Wei Luo
Shu-Guang Gao
Da-Zhi Su
Yu-Sheng Li
Chao Zeng
Guang-Hua Lei
Publication date: 01-11-2013
Publisher: Springer Japan
Published in: Modern Rheumatology / Issue 6/2013
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI: https://doi.org/10.1007/s10165-012-0818-3

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Conclusions

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