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Journal of the Association for Research in Otolaryngology
Published in: Journal of the Association for Research in Otolaryngology 6/2016

01-12-2016 | Review Article

Application of Mouse Models to Research in Hearing and Balance

Authors: Kevin K. Ohlemiller, Sherri M. Jones, Kenneth R. Johnson

Published in: Journal of the Association for Research in Otolaryngology | Issue 6/2016

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Abstract

Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.
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Metadata
Title
Application of Mouse Models to Research in Hearing and Balance
Authors
Kevin K. Ohlemiller
Sherri M. Jones
Kenneth R. Johnson
Publication date
01-12-2016
Publisher
Springer US
Published in
Journal of the Association for Research in Otolaryngology / Issue 6/2016
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI
https://doi.org/10.1007/s10162-016-0589-1

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