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Journal of the Association for Research in Otolaryngology

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01-12-2010

Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

Authors: Kevin K. Ohlemiller, Ashley R. Dahl, Patricia M. Gagnon

Published in: Journal of the Association for Research in Otolaryngology | Issue 4/2010

Abstract

Two inbred mouse strains, CBA/J and CBA/CaJ, have been used nearly interchangeably as ‘good hearing’ standards for research in hearing and deafness. We recently reported, however, that these two strains diverge after 1 year of age, such that CBA/CaJ mice show more rapid elevation of compound action potential (CAP) thresholds at high frequencies (Ohlemiller, Brain Res. 1277: 70–83, 2009). One contributor is progressive decline in endocochlear potential (EP) that appears only in CBA/CaJ. Here, we explore the cellular bases of threshold and EP disparities in old CBA/J and CBA/CaJ mice. Among the major findings, both strains exhibit a characteristic age (∼18 months in CBA/J and 24 months in CBA/CaJ) when females overtake males in sensitivity decline. Strain differences in progression of hearing loss are not due to greater hair cell loss in CBA/CaJ, but instead appear to reflect greater neuronal loss, plus more pronounced changes in the lateral wall, leading to EP decline. While both male and female CBA/CaJ show these pathologies, they are more pronounced in females. A novel feature that differed sharply by strain was moderate loss of outer sulcus cells (or ‘root’ cells) in spiral ligament of the upper basal turn in old CBA/CaJ mice, giving rise to deep indentations and void spaces in the ligament. We conclude that CBA/CaJ mice differ both quantitatively and qualitatively from CBA/J in age-related cochlear pathology, and model different types of presbycusis.

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Title: Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae
Authors: Kevin K. Ohlemiller
Ashley R. Dahl
Patricia M. Gagnon
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: Journal of the Association for Research in Otolaryngology / Issue 4/2010
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-010-0228-1

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Divergent Aging Characteristics in CBA/J and CBA/CaJ Mouse Cochleae

Abstract

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