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01-01-2021 | IgA Vasculitis | Original article

Serum levels of galactose-deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and IgA vasculitis

Authors: Mengmeng Tang, Xue Zhang, Xueqian Li, Lei Lei, Hejia Zhang, Chen Ling, Jie Ni, Jicheng Lv, Xiaorong Liu, Xiangmei Chen

Published in: Clinical and Experimental Nephrology | Issue 1/2021

Abstract

Objective

IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAV-N) are related diseases. Galactose-deficient IgA1 (Gd-IgA1) plays an important role in the pathology of IgAV-N and IgAN, so we aim to compare the serum levels of Gd-IgA1 in Chinese pediatric patients with IgAN, IgAV-N, and IgAV.

Methods

We retrospectively enrolled 52 patients with IgAN, 57 patients with IgAV-N, 26 patients with IgAV, and 40 healthy children. The serum levels of Gd-IgA1 were measured at the time of biopsy using a lectin-based ELISA method.

Results

Gd-IgA1 levels in IgAV-N patients and IgAN patients were higher than in healthy controls (303.94 ± 39.37 U/ml, 314.91 ± 47.79 U/ml vs. 273.57 ± 48.29 U/ml, P < 0.001), and Gd-IgA1 levels in IgAV-N patients were higher than in IgAV patients (303.94 ± 39/ml vs. 286. 21 ± 38.81 U/ml, P = 0.059), but the latter result is not statistically significant. The Gd-IgA1 levels in IgAV patients were comparable with those in healthy controls (286.21 ± 38.81 U/ml vs. 273.57 ± 48.29 U/ml, P = 0.267). Among the four groups, we did not observe significant correlations of Gd-IgA1 levels with eGFR, proteinuria, or the MEST-C score.

Conclusion

Serum Gd-IgA1 maybe involved in the pathogenesis of the IgAV-N and IgAN. However, we found no statistically significant correlation between Gd-IgA1 levels and clinical and pathological features.

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Title: Serum levels of galactose-deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and IgA vasculitis
Authors: Mengmeng Tang
Xue Zhang
Xueqian Li
Lei Lei
Hejia Zhang
Chen Ling
Jie Ni
Jicheng Lv
Xiaorong Liu
Xiangmei Chen
Publication date: 01-01-2021
Publisher: Springer Singapore
Keywords: IgA Vasculitis
Vasculitis
IgA Vasculitis
Vasculitis
Published in: Clinical and Experimental Nephrology / Issue 1/2021
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-020-01968-8

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Objective

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Results

Conclusion

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