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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 7/2019

Open Access 01-07-2019 | Diabetes | Original article

Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study

Authors: Satoshi Iimuro, Tetsuji Kaneko, Yasuo Ohashi, Tsuyoshi Watanabe, Kosaku Nitta, Tadao Akizawa, Seiichi Matsuo, Enyu Imai, Hirofumi Makino, Akira Hishida, for the CKD-JAC Investigators

Published in: Clinical and Experimental Nephrology | Issue 7/2019

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Abstract

Background

Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and to determine the high-risk population. In addition, we compared CKD population to general population.

Methods

We conducted a post hoc analysis of the chronic kidney disease-Japan cohort study, a multicenter prospective cohort study of 2966 patients with chronic kidney disease with a median 3.9 years of follow-up. We examined the hospitalization reasons and analyzed the risk factors.

Results

We found 2897 all-cause hospitalization events (252.3 events/1000 person-years), a hospitalization incidence 17.1-fold higher than that in an age- and sex-matched cohort from the general Japanese population. Kidney, eye and adnexa, and heart-related hospital admissions were the most common. All-cause hospitalization increased with chronic kidney disease stage and with the presence of diabetes. Patients with diabetes at enrollment had 345.7 hospitalization events/1000 person-years, which is considerably higher than 196.8 events/1000 person-years for those without diabetes. Survival analysis, using hospitalization as an event, showed earlier all-cause hospitalization with the progression of chronic kidney disease stage and diabetes. Cardiovascular disease hospitalizations were more strongly influenced by diabetes than chronic kidney disease stage.

Conclusions

Patients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease.
Appendix
Available only for authorised users
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Metadata
Title
Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study
Authors
Satoshi Iimuro
Tetsuji Kaneko
Yasuo Ohashi
Tsuyoshi Watanabe
Kosaku Nitta
Tadao Akizawa
Seiichi Matsuo
Enyu Imai
Hirofumi Makino
Akira Hishida
for the CKD-JAC Investigators
Publication date
01-07-2019
Publisher
Springer Singapore
Published in
Clinical and Experimental Nephrology / Issue 7/2019
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-019-01730-9

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