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Open Access 01-08-2019 | Invited review article

Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017

Author: Kazuhiro Hasegawa

Published in: Clinical and Experimental Nephrology | Issue 8/2019

Abstract

Tubules interact with glomeruli, which are composed of podocytes, parietal epithelial cells, mesangial cells, and glomerular endothelial cells. Glomerular–tubular balance and tubuloglomerular feedback are the two components of the tubular–glomerular interplay, which has been demonstrated to play roles in physiological renal function and in diabetic kidney disease (DKD), in which proteins leaking from glomeruli arrive at tubular regions, leading to further tubular injury caused by the accumulation of proteinuria-inducing reactive oxygens species and various cytokines. In the current review, we present our recent work identifying a novel tubular–glomerular interplay in DKD mediated by sirtuin 1 and nicotinamide mononucleotide.

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Title: Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017
Author: Kazuhiro Hasegawa
Publication date: 01-08-2019
Publisher: Springer Singapore
Published in: Clinical and Experimental Nephrology / Issue 8/2019
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-019-01719-4

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Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017

Abstract

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Abstract

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