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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 2/2014

01-04-2014 | Review Article

Causes and consequences of lipoprotein(a) abnormalities in kidney disease

Author: Florian Kronenberg

Published in: Clinical and Experimental Nephrology | Issue 2/2014

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Abstract

Lipoprotein(a) is one of the strongest genetically determined risk factors for cardiovascular disease, and patients with chronic kidney disease have major disturbances in lipoprotein(a) metabolism. Concentrations are increased and are influenced by glomerular filtration rate (GFR) and the amount of proteinuria. The reason for this elevation can be increased synthesis, as is the case for patients with nephrotic syndrome or those treated by peritoneal dialysis. In hemodialysis patients, a catabolic block is the reason for this elevation. The elevated concentrations might contribute to the tremendous cardiovascular risk in this particular population. In particular, the genetically determined small apolipoprotein(a) isoforms are associated with an increased risk for cardiovascular events and total mortality.
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Metadata
Title
Causes and consequences of lipoprotein(a) abnormalities in kidney disease
Author
Florian Kronenberg
Publication date
01-04-2014
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 2/2014
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-013-0875-8

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