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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 2/2009

01-04-2009 | Case Report

Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation

Authors: Kentaro Sakai, Joichi Usui, Hirayasu Kai, Masahiro Hagiwara, Naoki Morito, Chie Saito, Keigyou Yoh, Syuichi Tsuruoka, Kouichi Hirayama, Kumi Aita, Michio Nagata, Kunihiro Yamagata

Published in: Clinical and Experimental Nephrology | Issue 2/2009

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Abstract

A 29-year-old man with malignant lymphoma developed membranous nephropathy (MN) after allogeneic bone-marrow transplantation (BMT). There had been no obvious findings of graft versus host diseases (GVHD) after BMT, and the dosage of immunosuppressant drugs had not been reduced during this period. At the onset of MN, a few lymphoma cells still remained in the bone marrow; the patient achieved complete remission of MN after the disappearance of the lymphoma cells. In this case it is suggested that immune complexes including antigens expressed by lymphoma cells might induce MN. Therefore, this is a significant case that may reveal an alternative mechanism of the onset of MN related to BMT.
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Metadata
Title
Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation
Authors
Kentaro Sakai
Joichi Usui
Hirayasu Kai
Masahiro Hagiwara
Naoki Morito
Chie Saito
Keigyou Yoh
Syuichi Tsuruoka
Kouichi Hirayama
Kumi Aita
Michio Nagata
Kunihiro Yamagata
Publication date
01-04-2009
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 2/2009
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-008-0120-z

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