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International Journal of Clinical Oncology

Published in:

01-04-2019 | Original Article

Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population

Authors: Rong Wang, Hai-Mei Qin, Li Qin, Jing-Xi Wei, Yu-Xia Wei, Jun-Li Wang

Published in: International Journal of Clinical Oncology | Issue 4/2019

Abstract

Background

Emerging evidences were accumulated to support the view that GRP78 might be associated with multiple types of cancer. Given these, the aim of this study is to investigate the relationship between single nucleotide polymorphisms (SNPs) of GRP78 gene promoter and nasopharyngeal carcinoma (NPC).

Methods

Three SNPs (rs3216733, rs17840761 and rs17840762) in GRR78 promoter were estimated in 422 NPC patients and 452 controls. Genotyping was performed using SNaPshot SNP. Serum GRP78 level was performed by enzyme-linked immunosorbent assay (ELISA). Data were analyzed by SPSS 17.0 software.

Results

Significant association between rs3216733 polymorphism and NPC was observed (Cd vs. dd: OR = 0.57, 95% CI 0.43–0.76, P < 0.001; CC vs. dd: OR = 0.62, 95% CI 0.39–0.98, P = 0.043; Cd/CC vs. dd: OR = 0.58, 95% CI 0.44–0.76, P < 0.001; C vs. d OR = 0.70, 95% CI 0.57–0.86, P = 0.001). Additionally, we further found that expression were down-regulated in serum of patients with NPC carrying rs3216733 CC genotype when compared to that of dd genotype (P < 0.001).

Conclusion

The observations suggest that rs3216733 polymorphism in the GRP78 gene promoter may correlate with NPC susceptibility.

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Title: Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population
Authors: Rong Wang
Hai-Mei Qin
Li Qin
Jing-Xi Wei
Yu-Xia Wei
Jun-Li Wang
Publication date: 01-04-2019
Publisher: Springer Singapore
Published in: International Journal of Clinical Oncology / Issue 4/2019
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-018-1366-4

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Abstract

Background

Methods

Results

Conclusion

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