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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2010

Open Access 01-12-2010 | Research article

Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population

Authors: Xiao Zhu, Dong-Pei Li, Wen-Guo Fan, Marie CM Lin, Jin-Long Wang, Sheng-Qu Lin, Jian-Qing Huang, Hsiang-Fu Kung

Published in: BMC Medical Genetics | Issue 1/2010

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Abstract

Background

Hepatitis B virus (HBV) infection causes large amount of unfolding or false-folding protein accumulation in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78). The aim in the present study was to analyse the potential association between GRP78 single-nucleotide polymorphisms (SNPs) and the risk of HBV infection.

Methods

The associations between seven common GRP78 polymorphisms in the promoter (rs391957, rs17840762, rs17840761, rs11355458) and in the 3' untranslated region (UTR) (rs16927997, rs1140763, rs12009) and possible risk of chronic HBV infection were assessed in a case-control study. 496 cases and 539 individually matched healthy controls were genotyped.

Results

Overall, no associations were observed in genotypic analyses. In addition, haplotypes and diplotypes combining those SNPs in the promoter or in the 3' UTR in high linkage disequilibrium (LD) were also not associated with HBV risk.

Conclusion

These observations do not support a role for GRP78 polymorphisms in HBV infection in a predominantly Chinese Han population.
Appendix
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Metadata
Title
Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population
Authors
Xiao Zhu
Dong-Pei Li
Wen-Guo Fan
Marie CM Lin
Jin-Long Wang
Sheng-Qu Lin
Jian-Qing Huang
Hsiang-Fu Kung
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2010
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-11-83

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