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International Journal of Clinical Oncology

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01-12-2017 | Original Article

Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma

Authors: Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Hidenori Suzuki, Yusuke Koide, Yujiro Fukuda, Motoo Nomura, Takeshi Kodaira, Takeshi Shimizu, Yasuhisa Hasegawa

Published in: International Journal of Clinical Oncology | Issue 6/2017

Abstract

Backgroud

Laryngeal preservation is an important consideration when treating cervical esophageal cancers (CECs) such as laryngeal cancer. The standard treatment for CEC allowing laryngeal preservation is chemoradiotherapy. However, in cases of laryngeal cancer, chemoselection has also been applied as a treatment strategy that promotes larynx preservation. This strategy involves assigning the appropriate radical treatment according to the primary tumor’s response to induction chemotherapy. Since there have been no studies of the application of chemoselection in CEC cases, the present study compared the results, including laryngeal preservation rates, obtained upon applying chemoselection and chemoradiotherapy to CEC.

Study design

This was a retrospective cohort study of cervical esophageal squamous cell carcinoma patients treated using chemoselection or chemoradiotherapy at Aichi Cancer Center Hospital between January 2000 and March 2013. A total of 42 patients were enrolled.

Results

The 2-year overall survival and laryngeal preservation rates for the chemoselection group versus the primary radiotherapy group were 65.1 and 57.3 versus 40 and 83.3%, respectively (P = 0.017 and P = 0.122, respectively). The 2-year locoregional control rates for the chemoselection and primary radiotherapy groups were 68 and 25%, respectively (P = 0.045).

Conclusion

The chemoselection group achieved favorable results. Therefore, chemoselection can be applied as a treatment strategy for CEC.

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Title: Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma
Authors: Yusuke Nakata
Nobuhiro Hanai
Daisuke Nishikawa
Hidenori Suzuki
Yusuke Koide
Yujiro Fukuda
Motoo Nomura
Takeshi Kodaira
Takeshi Shimizu
Yasuhisa Hasegawa
Publication date: 01-12-2017
Publisher: Springer Japan
Published in: International Journal of Clinical Oncology / Issue 6/2017
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-017-1149-3

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Abstract

Backgroud

Study design

Results

Conclusion

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