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Neurosurgical Review
Published in: Neurosurgical Review 1/2016

01-01-2016 | Review

Spinal cord stimulation for Parkinson’s disease: a systematic review

Authors: Emerson Magno de Andrade, Maria Gabriela Ghilardi, Rubens Gisbert Cury, Egberto Reis Barbosa, Romulo Fuentes, Manoel Jacobsen Teixeira, Erich Talamoni Fonoff

Published in: Neurosurgical Review | Issue 1/2016

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Abstract

Axial symptoms are a late-developing phenomenon in the course of Parkinson’s disease (PD) and represent a therapeutic challenge given their poor response to levodopa therapy and deep brain stimulation. Spinal cord stimulation (SCS) may be a new therapeutic approach for the alleviation of levodopa-resistant motor symptoms of PD. Our purpose was to systematically review the effectiveness of SCS for the treatment of motor symptoms of PD and to evaluate the technical and pathophysiological mechanisms that may influence the outcome efficacy of SCS. A comprehensive literature search was conducted using electronic databases for the period from January 1966 through April 2014. The methodology utilized in this work follows a review process derived from evidence-based systematic review and meta-analysis of randomized trials described in the PRISMA statement. Reports examining SCS for the treatment of PD are limited. Eight studies with a total of 24 patients were included in this review. The overall motor score of the Unified Parkinson’s Disease Rating Scale in the on/off-stimulation condition remained unchanged in 6 patients and improved in 18 patients after SCS. SCS appears to yield positive results for PD symptoms, especially for impairments in gait function and postural stability. However, evidence is limited and long-term prospective studies will be required to identify the optimal candidates for SCS and the best parameters of stimulation and to fully characterize the effects of stimulation on motor and nonmotor symptoms of PD.
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Metadata
Title
Spinal cord stimulation for Parkinson’s disease: a systematic review
Authors
Emerson Magno de Andrade
Maria Gabriela Ghilardi
Rubens Gisbert Cury
Egberto Reis Barbosa
Romulo Fuentes
Manoel Jacobsen Teixeira
Erich Talamoni Fonoff
Publication date
01-01-2016
Publisher
Springer Berlin Heidelberg
Published in
Neurosurgical Review / Issue 1/2016
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-015-0651-1

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