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01-04-2007 | Case Report

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components

Authors: Susanne A. Kuhn, Uwe-Karsten Hanisch, Kristian Ebmeier, Christian Beetz, Michael Brodhun, Rupert Reichart, Christian Ewald, Thomas Deufel, Rolf Kalff

Published in: Neurosurgical Review | Issue 2/2007

Abstract

The case of a 7-year-old boy suffering from a supratentorial primitive neuroectodermal tumour (sPNET) at the age of 5 is presented. The tumour has been characterized by astrocytic areas within the sPNET revealing malignant transformation up to a multiform glioblastoma during the course of the disease. The clonal origin of both tumour components was established by loss of heterozygosity (LOH) analysis. Clinically, the tumour showed an aggressive biological behaviour with two recurrences. We discuss this very rare case and the first description of the clonal origin of distinct and distinguishable tumour components taking into consideration published literature.

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http://www.kinderkrebsinfo.de

Title: A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components
Authors: Susanne A. Kuhn
Uwe-Karsten Hanisch
Kristian Ebmeier
Christian Beetz
Michael Brodhun
Rupert Reichart
Christian Ewald
Thomas Deufel
Rolf Kalff
Publication date: 01-04-2007
Publisher: Springer-Verlag
Published in: Neurosurgical Review / Issue 2/2007
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-007-0069-5

At a glance: The STEP trials

Springer Medicine

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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