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Gastric Cancer

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01-01-2020 | Gastrointestinal Stromal Tumor | Original Article

Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia

Authors: Pablo Iruzubieta, Marta Monzón, Tomás Castiella, Teresa Ramírez, Concepción Junquera

Published in: Gastric Cancer | Issue 1/2020

Abstract

Background

Gastrointestinal stromal tumour (GIST) is a mesenchymal cancer which derives from interstitial cells of Cajal. To determine whether a relationship between Hedgehog (Hh) signalling pathway and primary cilia exists in GIST tumours is intended here.

Methods

Immunohistochemical, immunofluorescence and ultrastructural techniques were performed in this study.

Results

We show that GIST cells present primary cilia (an antenna-like structure based on microtubules). But, moreover, we prove Hedgehog signalling pathway activation in these tumours (a pathway related with tumoural features such as proliferation, migration or stemness) and we show for the first time that this signalling pathway activation in GIST is mediated by primary cilia, likely in a paracrine way.

Conclusion

Thus, primary cilia and Hedgehog signalling would be fundamental in tumoural microenvironment control of GIST cells for their maintenance, differentiation and proliferation.

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Title: Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia
Authors: Pablo Iruzubieta
Marta Monzón
Tomás Castiella
Teresa Ramírez
Concepción Junquera
Publication date: 01-01-2020
Publisher: Springer Singapore
Keyword: Gastrointestinal Stromal Tumor
Published in: Gastric Cancer / Issue 1/2020
Print ISSN: 1436-3291
Electronic ISSN: 1436-3305
DOI: https://doi.org/10.1007/s10120-019-00984-2

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Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia

Abstract

Background

Methods

Results

Conclusion

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