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Gastric Cancer
Published in: Gastric Cancer 3/2011

01-08-2011 | Original Article

Increased risk of tuberculosis after gastrectomy and chemotherapy in gastric cancer: a 7-year cohort study

Authors: Shiang-Fen Huang, Chung-Pin Li, Jia-Yih Feng, Yee Chao, Wei-Juin Su

Published in: Gastric Cancer | Issue 3/2011

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Abstract

Background

Gastrectomy for peptic ulcers and chemotherapy for malignancy are known risk factors for tuberculosis (TB). However, this relationship has rarely been investigated in patients with gastric cancer.

Methods

In a retrospective cohort study from 2000 to 2006, data for 2215 patients diagnosed with gastric cancer at our hospital were compared with data from the Centers for Disease Control (CDC), Taiwan, to identify confirmed cases of TB.

Results

In patients with gastric cancer without a history of gastrectomy and without previous anti-TB treatment, the overall crude incidence of new-onset TB was 788 per 100,000 person-years. Compared with the general population, the overall age-sex standardized incidence (SI) in gastric cancer patients was 134.3 (SI ratio [SIR]: 2.11, p < 0.05), and the recurrence rate among patients with previous anti-TB treatment was 18% (4/22) after gastric cancer diagnosis. Gastrectomy was a significant risk factor for active TB incidence [SI 159 (95% confidence interval [CI], 80–237, SIR: 2.5, p < 0.05), and chemotherapy alone seemed to be a risk factor, but was without statistical significance (SIR: 12.5, p > 0.05). Multivariate analysis showed old age, male gender, previous anti-TB treatment, and gastrectomy as significant risk factors for TB. In stratified analysis, an interaction between old TB patterns on chest films and chemotherapy was observed.

Conclusions

Old age, male gender, previous anti-TB treatment, and gastrectomy were significant risk factors for TB. An increased risk of TB incidence after chemotherapy was observed in patients with old TB pattern chest films initially, suggesting an interaction between chest film patterns and chemotherapy.
Appendix
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Metadata
Title
Increased risk of tuberculosis after gastrectomy and chemotherapy in gastric cancer: a 7-year cohort study
Authors
Shiang-Fen Huang
Chung-Pin Li
Jia-Yih Feng
Yee Chao
Wei-Juin Su
Publication date
01-08-2011
Publisher
Springer Japan
Published in
Gastric Cancer / Issue 3/2011
Print ISSN: 1436-3291
Electronic ISSN: 1436-3305
DOI
https://doi.org/10.1007/s10120-011-0037-1

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