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01-04-2022 | Chronic Inflammatory Bowel Disease | Original Article

The effect of photobiomodulation therapy on the management of chronic idiopathic large-bowel diarrhea in dogs

Authors: J. C. Alves, P. Jorge, A. Santos

Published in: Lasers in Medical Science | Issue 3/2022

Abstract

To evaluate photobiomodulation therapy’s effectiveness (PBMT) in managing chronic idiopathic large-bowel diarrhea. Thirty dogs were selected and divided into a control (CG) and treatment group (TG). CG received psyllium husk at the dose of 4 tablespoons/day for 30 days. TG received PBMT with a Class IV therapeutic laser, divided into three sessions on week 1, two sessions on week 2, and one session on week 3. A daily log of fecal characteristics was maintained, and on days 0, 8, 15, and 30, a canine inflammatory bowel disease index (CIBDAI) and body condition scores (BCS) were obtained. Results were compared using a Mann–Whitney test. Multiple regression was run to predict CIBDAI, Bristol stool scores, and diarrhea from different parameters. The Kaplan–Meier test was used to compare the occurrence rate of ≥ 1 day of diarrhea and ≥ 2 days of diarrhea by 30 days. Cox regression analysis to investigate interest covariates influences the same outcome. A p < 0.05 was set. The sample included 15 Belgian Malinois Shepherd Dogs, 10 German Shepherd Dogs, and 5 Dutch Shepherd Dog, with a mean age of 3.6 ± 2.3 years and a bodyweight of 24.6 ± 8.0 kg. TG showed an improvement in all scores and clinical signs, increased body weight, and BCS. An increased time of appearance of a second episode of diarrhea was observed in both groups. Activity level contributed to the prediction of defecation frequency and CIBDAI. PBMT significantly improved clinical signs and frequency of diarrhea episodes compared to psyllium husk.

Volkmann M, Steiner JMM, Fosgate GTT et al (2017) Chronic diarrhea in dogs — retrospective study in 136 cases. J Vet Intern Med 31:1043–1055. https://doi.org/10.1111/jvim.14739CrossRefPubMedPubMedCentral

Dandrieux JRS, Mansfield CS (2019) Chronic enteropathy in canines: prevalence, impact and management strategies. Vet Med Res Reports 10:203–214. https://doi.org/10.2147/VMRR.S162774CrossRef

Rose L, Rose J, Gosling S, Holmes M (2017) Efficacy of a probiotic-prebiotic supplement on incidence of diarrhea in a dog shelter: a randomized, double-blind, placebo-controlled trial. J Vet Intern Med 31:377–382. https://doi.org/10.1111/jvim.14666CrossRefPubMedPubMedCentral

Nixon SL, Rose L, Muller AT (2019) Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: a randomized, placebo-controlled, double-blinded clinical study. J Vet Intern Med 33:1286–1294. https://doi.org/10.1111/jvim.15481CrossRefPubMedPubMedCentral

Lecoindre P, Gaschen FP (2011) Chronic idiopathic large bowel diarrhea in the dog. Vet Clin North Am Small Anim Pract 41:447–456. https://doi.org/10.1016/j.cvsm.2011.02.004CrossRefPubMed

Simpson JW (1998) Diet and large intestinal disease in dogs and cats. J Nutr 128:2717S-2722S. https://doi.org/10.1093/jn/128.12.2717SCrossRefPubMed

Rudinsky AJ, Rowe JC, Parker VJ (2018) Nutritional management of chronic enteropathies in dogs and cats. J Am Vet Med Assoc 253:570–578. https://doi.org/10.2460/javma.253.5.570CrossRefPubMed

Leib MS (2000) Treatment of chronic idiopathic large-bowel diarrhea in dogs with a highly digestible diet and soluble fiber. J Vet Intern Med 14:27–32CrossRef

McKenzie E, Riehl J, Banse H et al (2010) Prevalence of diarrhea and enteropathogens in racing sled dogs. J Vet Intern Med 24:97–103. https://doi.org/10.1111/j.1939-1676.2009.0418.xCrossRefPubMed

10.

Gagné JW, Wakshlag JJ, Simpson KW et al (2013) Effects of a synbiotic on fecal quality, short-chain fatty acid concentrations, and the microbiome of healthy sled dogs. BMC Vet Res 9:246. https://doi.org/10.1186/1746-6148-9-246CrossRefPubMedPubMedCentral

11.

Whelan K, Schneider SM (2011) Mechanisms, prevention, and management of diarrhea in enteral nutrition. Curr Opin Gastroenterol 27:152–159. https://doi.org/10.1097/MOG.0b013e32834353cbCrossRefPubMed

12.

Lever E, Cole J, Scott SM et al (2014) Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther 40:750–758. https://doi.org/10.1111/apt.12913CrossRefPubMed

13.

Alves JC, Santos A, Jorge P, Pitães A (2021) The use of soluble fibre for the management of chronic idiopathic large-bowel diarrhoea in police working dogs. BMC Vet Res 17:100. https://doi.org/10.1186/s12917-021-02809-wCrossRefPubMedPubMedCentral

14.

Wakshlag JJJ (2018) The Role of Nutrition in Canine Performance and Rehabilitation. In: Zink C, Van Dyke J (eds) Canine Sports Medicine and Rehabilitation, 2nd ed. John Wiley & Sons, Inc., pp 72–95. https://doi.org/10.1002/9781119380627

15.

Looney AL, Huntingford JL, Blaeser LL, Mann S (2018) A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis. Can Vet J La Rev Vet Can 59:959–966

16.

Bruno E, Canal S, Antonucci M et al (2020) Perilesional photobiomodulation therapy and physical rehabilitation in post-operative recovery of dogs surgically treated for thoracolumbar disk extrusion. BMC Vet Res 16:120. https://doi.org/10.1186/s12917-020-02333-3CrossRefPubMedPubMedCentral

17.

Bennaim M, Porato M, Jarleton A et al (2017) Preliminary evaluation of the effects of photobiomodulation therapy and physical rehabilitation on early postoperative recovery of dogs undergoing hemilaminectomy for treatment of thoracolumbar intervertebral disk disease. Am J Vet Res 78:195–206. https://doi.org/10.2460/ajvr.78.2.195CrossRefPubMed

18.

Anders J, KobielaKertz A, Wu X (2017) Basic principles of photobiomodulation and its effects at the cellular, tissue, and system levels. In: Riegel RJ, Goldbold J (eds) Laser Therapy in Veterinary Medicine: Photobiomodulation. Wiley Blackwell, Ames, pp 36–52CrossRef

19.

Abreu Villela P, de Carvalho de Souza N, Baia JD et al (2017) Antimicrobial photodynamic therapy (aPDT) and photobiomodulation (PBM – 660 nm) in a dog with chronic gingivostomatitis. Photodiagnosis Photodyn Ther 20:273–275. https://doi.org/10.1016/j.pdpdt.2017.10.012CrossRefPubMed

20.

Watson AH, Brundage CM (2019) Photobiomodulation as an inflammatory therapeutic following dental prophylaxis in canines. Photobiomodulation Photomedicine Laser Surg 37:276–281. https://doi.org/10.1089/photob.2018.4614CrossRef

21.

Zigmond E, Varol C, Kaplan M et al (2014) Low-level light therapy induces mucosal healing in a murine model of dextran-sodium-sulfate induced colitis. Photomed Laser Surg 32:450–457. https://doi.org/10.1089/pho.2013.3626CrossRefPubMed

22.

Azadgoli B, Baker RY (2016) Laser applications in surgery. Ann Transl Med 4:452–452. https://doi.org/10.21037/atm.2016.11.51CrossRefPubMedPubMedCentral

23.

KoohiHosseinabadi O, Behnam MA, Khoradmehr A et al (2020) Benign prostatic hyperplasia treatment using plasmonic nanoparticles irradiated by laser in a rat model. Biomed Pharmacother 127:110118. https://doi.org/10.1016/j.biopha.2020.110118CrossRef

24.

Behnam MA, Emami F, Sobhani Z (2021) PEGylated carbon nanotubes decorated with silver nanoparticles: fabrication, cell cytotoxicity and application in photo thermal therapy. Iran J Pharm Res IJPR 20:91–104. https://doi.org/10.22037/ijpr.2019.112339.13697CrossRefPubMed

25.

Jergens AE, Schreiner CA, Frank DE et al (2003) A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med 17:291–297. https://doi.org/10.1111/j.1939-1676.2003.tb02450.xCrossRefPubMed

26.

Huang H-PP, Lien Y-HH (2017) Effects of a structured exercise programme in sedentary dogs with chronic diarrhoea. Vet Rec 180:224–224. https://doi.org/10.1136/vr.103902CrossRefPubMed

27.

Langlois DK, Koenigshof AM, Mani R (2020) Metronidazole treatment of acute diarrhea in dogs: a randomized double blinded placebo-controlled clinical trial. J Vet Intern Med 34:98–104. https://doi.org/10.1111/jvim.15664CrossRefPubMed

28.

Whittemore JC, Moyers TD, Price JM (2019) Randomized, controlled, crossover trial of prevention of antibiotic-induced gastrointestinal signs using a synbiotic mixture in healthy research dogs. J Vet Intern Med 33:1619–1626. https://doi.org/10.1111/jvim.15553CrossRefPubMedPubMedCentral

29.

Godine R (2017) Abdominal Conditions. In: Riegel RJ, Goldbold J (eds) Laser Therapy in Veterinary Medicine, 1st edn. John Wiley & Sons Ltd, Chichester, pp 169–178CrossRef

30.

Laflamme D (1997) Development and validation of a body condition score system for dogs. Canine Pract 22:10–15

31.

Blake MR, Raker JM, Whelan K (2016) Validity and reliability of the Bristol Stool Form Scale in healthy adults and patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 44:693–703. https://doi.org/10.1111/apt.13746CrossRefPubMed

32.

Wakshlag J, Simpson K, Struble A, Dowd S (2011) Negative fecal characteristics are associated with pH and feca flora alterations during dietary changes in dogs. Int J Appl Res Vet Med 9:278–283

33.

Toresson L, Steiner JM, Suchodolski JS, Spillmann T (2016) Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia. J Vet Intern Med 30:101–107. https://doi.org/10.1111/jvim.13797CrossRefPubMed

34.

Yuki M, Hirano T, Nagata N et al (2016) Clinical utility of diagnostic laboratory tests in dogs with acute pancreatitis: a retrospective investigation in a primary care hospital. J Vet Intern Med 30:116–122. https://doi.org/10.1111/jvim.13660CrossRefPubMed

35.

Chang Y-M, Hadox E, Szladovits B, Garden OA (2016) Serum biochemical phenotypes in the domestic dog. PLoS ONE 11:e0149650. https://doi.org/10.1371/journal.pone.0149650CrossRefPubMedPubMedCentral

36.

Redfern A, Suchodolski J, Jergens A (2017) Role of the gastrointestinal microbiota in small animal health and disease. Vet Rec 181:370–370. https://doi.org/10.1136/vr.103826CrossRefPubMed

37.

Gareau M, Silva M, Perdue M (2008) Pathophysiological mechanisms of stress-induced intestina damage. Curr Mol Med 8:274–281. https://doi.org/10.2174/156652408784533760CrossRefPubMed

38.

Peters HPFPF, Bos M, Seebregts L et al (1999) Gastrointestinal symptoms in long-distance runners, cyclists, and triathletes: prevalence, medication, and etiology. Am J Gastroenterol 94:1570–1581. https://doi.org/10.1111/j.1572-0241.1999.01147.xCrossRefPubMed

39.

Bartels KE (2017) Therapy Laser Safety. In: Riegel RJ, Goldbold J (eds) Laser Therapy in Veterinary Medicine, 1st edn. Wiley Blackwell, Ames, pp 29–35CrossRef

Title: The effect of photobiomodulation therapy on the management of chronic idiopathic large-bowel diarrhea in dogs
Authors: J. C. Alves
P. Jorge
A. Santos
Publication date: 01-04-2022
Publisher: Springer London
Keywords: Chronic Inflammatory Bowel Disease
Diarrhea
Diarrhea
Laser
Published in: Lasers in Medical Science / Issue 3/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03469-w

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The effect of photobiomodulation therapy on the management of chronic idiopathic large-bowel diarrhea in dogs

Abstract

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