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01-06-2020 | Ibuprofen | Original Article

Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study

Authors: Eduardo Costa Nunes, Fernando José Herkrath, Eduardo Hideki Suzuki, Erivan Clementino Gualberto Júnior, André Augusto Franco Marques, Emílio Carlos Sponchiado Júnior

Published in: Lasers in Medical Science | Issue 4/2020

Abstract

The aim of the study was to compare the effect of Ibuprofen and the application of photobiomodulation therapy protocol on the reduction of postoperative pain in endodontically treated teeth using a randomized clinical trial design. Seventy patients, diagnosed with symptomatic irreversible pulpitis, were selected. Treatment was performed by a single operator; a reciprocal system was used to prepare the canals; they were obturated using the Tagger’s hybrid technique and coronally sealed with glass-ionomer cement. After treatment, patients were randomly divided into 2 groups. In the active control group, two Ibuprofen 600 mg tablets were administered within a 12-h interval. In the photobiomodulation therapy group, the irradiation was applied after treatment. The evaluation of postoperative pain was performed by another researcher blinded to the groups at 6, 12, 24, and 72 h intervals after treatment. To measure the outcome, two pain scales were used: numerical rate scale (NRS) and verbal rate scale (VRS). Data were analyzed using the chi-square, Mann-Whitney, and Wilcoxon paired tests. Outcome was superior with photobiomodulation therapy at 6 h (p < 0.001), 12 h (p = 0.005), and 24 h (p < 0.001) intervals compared with Ibuprofen. The results for the 72 h (p = 0.317) interval were similar, both in the VRS and NRS scales. It may be concluded that the use of photobiomodulation therapy was effective in reducing pain within the first 24 h when compared with the administration of Ibuprofen 600 mg.

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Parirokh M, Sadr S, Nakhaee N, Abott PV, Manochehrifar H (2014) Comparison between prescription of regular or on-demand ibuprofen on postoperative pain after single-visit root canal treatment of teeth with irreversible pulpitis. J Endod 40(2):151–154. https://doi.org/10.1016/j.joen.2013.09.024 PubMed

Praveen R, Thakur S, Kirthiga M (2016) Comparative evaluation of premedication with ketorolac and prednisolone on postendodontic pain: a double-blind randomized controlled trial. J Endod 43:667–673. https://doi.org/10.1016/j.joen.2016.12.012

Mokhtari F, Yazdi K, Mahabadi AM, Moradesi SJ, Hamzeheil Z (2015) Effect of premedication with indomethacin and ibuprofen on postoperative endodontic pain: a clinical trial. Iran Endod J 11:57–62. https://doi.org/10.7508/iej.2016.01.011 PubMedPubMedCentral

Comparin D, Moreira L, Souza EM, De Deus G, Arias A, Silva EJNL (2017) Postoperative pain after endodontic retreatment using rotary or reciprocation instruments: a randomized clinical trial. J Endod 43:1084–1088. https://doi.org/10.1016/j.joen.2017.02.010 PubMed

Wail M, Neamat H, Hassan M (2016) Double-blind randomized placebo-controlled clinical trial of efficiency of nonsteroidal anti-inflammatory drugs in the control of post-endodontic pain. J Endod 42:835–842. https://doi.org/10.1016/j.joen.2016.02.014

Emara RS, Abou HM, Nasr EL, Boghdadi EL (2019) Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. Int Endod J 52:288–296. https://doi.org/10.1111/iej.13012 PubMed

Jalalzadeh SM, Manavi A, Shahriari S, Santos FA (2010) Pochapski MT (2010) effect of pretreatment of prednisolone on postendodontic pain: a double blind parallel-randomized clinical trial. J Endod 36:978–981. https://doi.org/10.1016/j.joen.2010.03.015 PubMed

Shirvani A, Shamszadeh S, Eghbal M, Marvasti LA, Asgary S (2017) Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis- a systematic review and meta-analysis. Clin Oral Investig 21:43–52. https://doi.org/10.1007/s00784-016-1974-1 PubMed

Pochapski MT, Santos FA, Andrade ED, Sydney GB (2009) Effect of pretreatment dexamethasone on postendodontic pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:790–795. https://doi.org/10.1016/j.tripleo.2009.05.014 PubMed

10.

Lopes L, Herkrath F, Vianna ECB, Gualberto Júnior EC, Marques AAF, Sponchiado Júnior EC (2019) Effect of photobiomodulation therapy on postoperative pain after endodontic treatment: a randomized, controlled, clinical study. Clin Oral Investig 23(1):285–292. https://doi.org/10.1007/s00784-018-2435-9 PubMed

11.

Read JK, Mcclanahan SB, Khan A, Lunos S, Bowles WR (2014) Effect of ibuprofen on masking endodontic diagnosis. J Endod 40(8):1058–1062. https://doi.org/10.1016/j.joen.2014.05.004 PubMed

12.

Taggar T, Khan A (2017) A randomized clinical trial comparing 2 ibuprofen formulations in patients with acute odontogenic pain. J Endod. https://doi.org/10.1016/j.joen.2016.12.017 PubMed

13.

Smith EA, Marshal JG, Selph S, Barker DR, Sedgley CM (2017) Nonsteroidal anti-inflammatory drugs for managing postoperative endodontic pain in patients who present with preoperative pain: a systematic review and meta-analysis. J Endod 43(1):7–15. https://doi.org/10.1016/j.joen.2016.09.010 PubMed

14.

Noguera-Gonzalez D, Cerda-Cristerna BI, Chavarria-Bolaños D, Flores-Reyes H, Pozos-Guillen A (2013) Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial. Int Endod J 46(11):1056–1062. https://doi.org/10.1111/iej.12099 PubMed

15.

Shahi S, Mokhtari H, Rahimi S, Yavari HR, Narimani S, Abdolharimi M, Nezafati S (2013) Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial. J Endod 39(2):160–162. https://doi.org/10.1016/j.joen.2012.10.011 PubMed

16.

Menhinick KA, Gutmann JL, Regan JD, Taylor SE, Buschang PH (2004) The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study. Int Endod J 37:531–541PubMed

17.

Aslan H, Ezig DY, Ertugru K, Karatas E, Unlu MA, Ahmed HMA (2017) Effect of low-level laser therapy on postoperative pain after root canal retreatment: a preliminary placebo-controlled, triple-blind, randomized clinical trial. J Endod 43:1765–1769. https://doi.org/10.1016/j.joen.2017.06.028

18.

Li FJ, Zhang JY, Zeng XT (2015) Low-level laser therapy for orthodontic pain: a systematic review. Lasers Med Sci 30:1789–1803. https://doi.org/10.1007/s10103-014-1661-x PubMed

19.

Mohamed A, Hengameh A, Amir HD, Daghayeghi AH, Mojahedi SM, Azari-Marhabi (2017) Management of post endodontic retreatment pain with low level laser therapy. J Lasers Med Sci 8(3):128–131. https://doi.org/10.15171/jlms.2017.23

20.

Garcia VG, Lima MA, Okamoto T, Milanezi LA, Gualberto EC Jr, Fernandes LA, Almeida JM, Theodoro LH (2010) Effect of photodynamic therapy on the healing of cutaneous third-degree-burn: histological study in rats. Lasers Med Sci 25:221–228. https://doi.org/10.1007/s10103-009-0694-z PubMed

21.

Pallota RC, Bjordal JM, Frico L, Leal EC Jr, Teixeira S, Marcos R, Ramos L, Messias F, RAB L-M (2012) Infrared (810nm) low-level laser therapy on rat experimental knee inflammation. Lasers Med Sci 27:71–78. https://doi.org/10.1007/s10103011-0906-1

22.

Karu TI (2010) Mitochondrial mechanisms of photo-biomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg 28:159–160. https://doi.org/10.1089/pho.2010.2789 PubMed

23.

Albuquerque Pontes GM, Vieira RP, Tomazoni SS, Caires CO, Nemeth V, Vanin AA, Santos LA, Pinto HD, Marcos RL, Bjordal JM, de Carvalho PT, Leal-Junior EC (2015) Effect of pre-irradiation with different doses, wavelengths, and application intervals of low-level laser therapy on cytochrome c oxidase activity in intact skeletal muscle of rats. Lasers Med Sci 30:59–66. https://doi.org/10.1007/s10103-014-1616-2 PubMed

24.

Wu JY, Chen CH, Wang CZ, Ho ML, Yeh ML, Wang YH (2013) Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells by modulating intracellular cyclic AMP level and NF-kB activity. PLoS One 8:1–9. https://doi.org/10.1371/journal.pone.0054067

25.

Chen Y, Chen XL, Zou XL, Chen SZ, Zou J, Wang Y. (2019) Efficacy of low-level laser therapy in pain management after root canal treatment or retreatment: a systematic review. Lasers Med Sci. https://doi.org/10.1007/s10103-019-02793-6 PubMed

26.

Faul F, Erdfelder E, Lang A-G, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175–191PubMed

27.

Farroch F, Hosein E, Alireza M et al (2017) Evaluation of adjunctive effect of low-level laser therapy on pain, swelling and trismus after surgical removal of impacted lower third molar: a double blind randomized clinical trial. Laser Ther 26(3):181–187

28.

Farias RD, Closs LQ, Miguens JR, Sergio Q (2016) Evaluation of the use of low-level laser therapy in pain control in orthodontic patients: a randomized split-mouth clinical trial. Angle Ortod 86(2):193–198. https://doi.org/10.2319/122214-933.1

29.

Passarella S, Karu T (2014) Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation. J Photochem Photobiol B 140:344–358. https://doi.org/10.1016/j.jphotobiol.2014.07.021 PubMed

30.

Fabre SC, Navarro RL, Oltramari VP, Fabre HSC, Navarro RL, Oltramari-Navarro PVP, Oliveira RF, Pires-Oliveira DAA, Andraus RAC, Fuirini N, Fernandes KBP (2015) Anti-inflammatory and analgesic effects of low-level laser therapy on the postoperative healing process. J Phys Ther Sci 27:1645–1648. https://doi.org/10.1589/jpts.27.1645 PubMedPubMedCentral

31.

Ezig DY, Aslan H (2018) Effect of low-level laser therapy on postoperative pain in molars with symptomatic apical periodontitis: a randomized placebo-controlled clinical trial. J Endod 44:1610–1615. https://doi.org/10.1016/j.joen.2018.07.002

32.

Metin R, Tatli U, Evlice B (2018) Effects of low-level laser therapy on soft and hard tissue healing after endodontic surgery. Lasers Med Sci 33:1699–1706. https://doi.org/10.1007/s10103-018-2523-8 PubMed

33.

Dominkus M, Nicolakis M, Kotz R, Wilkinson FE, Kaiser RR, Chlud K (1996) Comparison of tissue and plasma levels of ibuprofen after oral and topical administration. Arzneimittelforschung 46(12):1138–1143PubMed

34.

Rother M, Rother I (2011) Placebo controlled, crossover validation study of oral ibuprofen and topical hydrocortisone-21-acetate for a model of ultraviolet B radiation (UVR)-induced pain and inflammation. J Pain Res 4:357–363. https://doi.org/10.2147/JPR.S24821 PubMedPubMedCentral

35.

Christensen S, Paluch E, Jayawardena S, Daniels S, Meeves S (2017) Analgesic efficacy of a new immediate-release/extended-release formulation of ibuprofen: results from single- and multiple-dose postsurgical dental pain studies. Clin Pharmacol Drug Dev 6(3):302–312. https://doi.org/10.1002/cpdd.297 PubMed

36.

Alonaizan FA, Alfawaz YF (2019) Is phototherapy effective in the management of postoperative endodontic T pain? A systematic review of randomized controlled clinical trials. Photodiagn Photodyn Ther 26:53–58. https://doi.org/10.1016/j.pdpdt.2019.03.003

37.

Williamson A, Hoggart B (2005) Pain: a review of three commonly used pain rating scales. J Clin Nurs 14:798–804. https://doi.org/10.1111/j.1365-2702.2005.01121.x PubMed

Title: Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study
Authors: Eduardo Costa Nunes
Fernando José Herkrath
Eduardo Hideki Suzuki
Erivan Clementino Gualberto Júnior
André Augusto Franco Marques
Emílio Carlos Sponchiado Júnior
Publication date: 01-06-2020
Publisher: Springer London
Keyword: Ibuprofen
Published in: Lasers in Medical Science / Issue 4/2020
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-019-02929-8

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Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study

Abstract

Keynote webinar | Spotlight on sleep in brain health

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Abstract

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