Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 8/2019

01-10-2019 | Stroke | Original Article

Study of transcranial therapy 904 nm in experimental model of stroke

Authors: Eliane Gonçalves de Jesus Fonseca, Ariele Pedroso, Débora Neuls, Danilo Barbosa, Francisco José Cidral-Filho, Afonso Shiguemi Inoue Salgado, Angela Dubiela, Emerson Carraro, Ivo Ilvan Kerppers

Published in: Lasers in Medical Science | Issue 8/2019

Login to get access

Abstract

Cerebrovascular accidents (CVAs), commonly known as strokes, can damage the brain through vascular injuries caused by either blood vessel blockages (ischemic stroke) or ruptures (hemorrhagic stroke) which disrupt regular brain blood supply and can cause severe damage to the individual. The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device (904 nm, 110 mW, 7 J/cm2) on neurogenesis, muscle resistance, and motor behavior in animals submitted to an experimental model of hemiplegia. The sample consisted of 30 Wistar rats, divided into two groups: control group (GC) and 904-nm LED-treated group (TG). All animals underwent stereotactic surgery for electrode implant and subsequent electrolytic injury to induce an ischemic stroke. TG was subjected to daily LED irradiation (904 nm, 110 mW, 7 J/cm2) for 63 s. Suspension test results indicate an improvement of TG muscle resistance when compared with baseline evaluation (BLT); a reduction in open-field freezing time and the number of fecal bolus pellets suggest diminished anxiety induced by 904-nm LED treatment on treatment days 7 and 21 (TG7 and TG21) compared with the baseline results; and lastly, histological analysis showed important signs of neurogenesis in TG in comparison to CG, especially on treatment days 7 and 21 (TG7 and TG21). In conclusion, the present study suggests that 904-nm LED irradiation may beneficially affect neurogenesis, muscle resistance, and animal motor behavior following ischemic CVA.
Literature
1.
Thrift AG, Cadilhac DA, Thayabaranathan T, Howard G, Howard VJ, Rothwell PM, Donnan GA (2014) Global stroke statistics. Int J Stroke 9:6–18CrossRefPubMed
2.
Yang L, Tucker D, Dong Y, Wu C, Lu Y, Li Y, Zhang Q (2018) Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells. Exp Neurol 299:86–96CrossRefPubMed
3.
Andrabi SS, Parvez S, Tabassum H (2017) Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats. Dis Model Mech 10:787–796CrossRefPubMedPubMedCentral
4.
Lee HI, Lee SW, Kim NG, Parque KJ, Choi BT, Shin YI, Shin HK (2017) Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke. J Biophotonics 10:1502–1513CrossRefPubMed
5.
Morries LD, Cassano P, Henderson TA (2015) Treatments for traumatic brain injury with emphasis on transdermal infrared laser phototherapy. Neuropsychiatr 11:2159–2175
6.
Lee HI, Lee SW, Kim NG, Park KJ, Choi BT, Shin YI, Shin HK (2017) Low-level light emitting diode therapy promotes long-term functional recovery after experimental stroke in mice. J Biophotonics 10(12):1761–1771CrossRefPubMed
7.
Yang Y, Zhao Q, Zhang Y, Wu Q, Jiang X, Cheng G (2018) Effect of mirror therapy on recovery of stroke survivors: a systematic review and network meta-analysis. Neuroscience 390:318–336CrossRefPubMed
8.
9.
Wang Q, Yang L, Wang Y (2015) Enhanced differentiation of neural stem cells to neurons and promotion of neurite outgrowth by oxygen–glucose deprivation. Int J Dev Neurosci 43:50–57CrossRefPubMed
10.
11.
12.
Pazaiti A, Soubasi V, Spandou E, Karkavelas G, Georgiou T, Karakis P, Guiba-Tziampiri O (2009) Evaluation of long-lasting sensorimotor consequences following neonatal hypoxic-ischemic brain injury in rats: The neuroprotective role of MgSO4. Neonatology 95:33–40
13.
Sestakova N, Puzserova A, Kluknavsky M, Bernatova I (2013) Determination of motor activity and anxiety-related behavior in rodents: methodological aspects and role of nitric oxide. Interdiscip Toxicol 6(3):126–135CrossRefPubMedPubMedCentral
14.
Miri AL, Hosni AP, Gomes JC, Kerppers II, Da Silva Pereira MC (2017) L-tryptophan study on depression in Alzheimer’s disease in experimental models. J Phys Educ 28(1):2839CrossRef
15.
Paxinos GC (1986) Watson The rat brain in stereotaxic coordinates. Academic, New York, p 8
16.
Kerppers II, Lima CJ, Fernandes AB, Villaverde AB (2015) Effect of light-emitting diode (ʎ 627 nm and 945 nm ʎ) treatment on first intention healing: Immunohistochemical analysis. Lasers Med Sci 30(1):397–401CrossRefPubMed
17.
Naeser M, Ho M, Martin P, Treglia E, Krengel M, Hamblin M, Baker E (2012) Improved language after scalp application of red/near-infrared light-emitting diodes: pilot study supporting a new, noninvasive treatment for chronic aphasia. Procedia Soc Behav Sci 61:138–139CrossRef
18.
Henderson TA, Morries LD (2015) Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain? Neuropsychiatr Dis Treat 11:2191CrossRefPubMedPubMedCentral
19.
20.
Vahid-Ansari F, Lagace DC, Albert PR (2016) Persistent post-stroke depression in mice following unilateral medial prefrontal cortical stroke. Transl Psychiatry 6(8):863CrossRef
21.
22.
Lee HI, Park JH, Park MY, Kim NG, Parque KJ, Choi BT, Shin HK (2016) Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice. Restor Neurol Neurosci 34(2):201–214PubMed
Metadata
Title
Study of transcranial therapy 904 nm in experimental model of stroke
Authors
Eliane Gonçalves de Jesus Fonseca
Ariele Pedroso
Débora Neuls
Danilo Barbosa
Francisco José Cidral-Filho
Afonso Shiguemi Inoue Salgado
Angela Dubiela
Emerson Carraro
Ivo Ilvan Kerppers
Publication date
01-10-2019
Publisher
Springer London
Keyword
Stroke
Published in
Lasers in Medical Science / Issue 8/2019
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-019-02758-9

Other articles of this Issue 8/2019

Lasers in Medical Science 8/2019 Go to the issue

Brief Report

Enhancing Er:YAG bactericidal effect against Enterococcus faecalis biofilm in vitro

Original Article

Fractional CO2 laser treatment for post-surgical lip scars in cleft lip and palate patients

Correction

Correction to: Inverse heat transfer analysis in detecting tissue optical properties using laser

Original Article

Quadriceps femoris performance after resistance training with and without photobiomodulation in elderly women: a randomized clinical trial

Original Article

Low-level laser therapy affects dentinogenesis and angiogenesis of in vitro 3D cultures of dentin-pulp complex

Original Article

Changes in local skin temperature after the application of a pulsed Nd:YAG laser to healthy subjects: a prospective crossover controlled trial