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Published in: Lasers in Medical Science 2/2018

01-02-2018 | Review Article

Low-level laser therapy for the treatment of androgenic alopecia: a review

Authors: Evan Darwin, Alexandra Heyes, Penelope A. Hirt, Tongyu Cao Wikramanayake, Joaquin J. Jimenez

Published in: Lasers in Medical Science | Issue 2/2018

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Abstract

There are many new low-level laser technologies that have been released commercially that claim to support hair regrowth. In this paper, we will examine the clinical trials to determine whether the body of evidence supports the use of low-level laser therapy (LLLT) to treat androgenic alopecia (AGA). A literature search was conducted through Pubmed, Embase, and Clinicaltrials.​gov for clinical trials using LLLT to treat AGA. Thirteen clinical trials were assessed. Review articles were not included. Ten of 11 trials demonstrated significant improvement of androgenic alopecia in comparison to baseline or controls when treated with LLLT. In the remaining study, improvement in hair counts and hair diameter was recorded, but did not reach statistical significance. Two trials did not include statistical analysis, but showed marked improvement by hair count or by photographic evidence. Two trials showed efficacy for LLLT in combination with topical minoxidil. One trial showed efficacy when accompanying finasteride treatment. LLLT appears to be a safe, alternative treatment for patients with androgenic alopecia. Clinical trials have indicated efficacy for androgenic alopecia in both men and women. It may be used independently or as an adjuvant of minoxidil or finasteride. More research needs to be undertaken to determine the optimal power and wavelength to use in LLLT as well as LLLT’s mechanism of action.
Literature
2.
go back to reference Piraccini BM, Alessandrini A (2014) Androgenetic alopecia. Giornale italiano di dermatologia e venereologia 149(1):15–24 Piraccini BM, Alessandrini A (2014) Androgenetic alopecia. Giornale italiano di dermatologia e venereologia 149(1):15–24
4.
go back to reference Wells PA, Willmoth T, Russell RJ (1995) Does fortune favour the bald? Psychological correlates of hair loss in males. Br J Psychol 86(Pt 3):337–344CrossRefPubMed Wells PA, Willmoth T, Russell RJ (1995) Does fortune favour the bald? Psychological correlates of hair loss in males. Br J Psychol 86(Pt 3):337–344CrossRefPubMed
5.
go back to reference Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ (1998) Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol 39(4 Pt 1):578–589CrossRefPubMed Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ (1998) Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol 39(4 Pt 1):578–589CrossRefPubMed
7.
go back to reference Ghanaat M (2010) Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. South Med J 103(9):917–921CrossRefPubMed Ghanaat M (2010) Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. South Med J 103(9):917–921CrossRefPubMed
11.
go back to reference Bjordal JM, Couppe C, Chow RT, Tuner J, Ljunggren EA (2003) A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother 49(2):107–116CrossRefPubMed Bjordal JM, Couppe C, Chow RT, Tuner J, Ljunggren EA (2003) A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother 49(2):107–116CrossRefPubMed
12.
go back to reference Mester E, Szende B, Tota J (1967) Effect of laser on hair growth of mice. Kiserl Orvostud 19:628–631 Mester E, Szende B, Tota J (1967) Effect of laser on hair growth of mice. Kiserl Orvostud 19:628–631
13.
go back to reference Moreno-Arias G, Castelo-Branco C, Ferrando J (2002) Paradoxical effect after IPL photoepilation. Dermatol Surg 28(11):1013–1016 discussion 1016PubMed Moreno-Arias G, Castelo-Branco C, Ferrando J (2002) Paradoxical effect after IPL photoepilation. Dermatol Surg 28(11):1013–1016 discussion 1016PubMed
16.
go back to reference Pastore D, Greco M, Passarella S (2000) Specific helium-neon laser sensitivity of the purified cytochrome c oxidase. Int J Radiat Biol 76(6):863–870CrossRefPubMed Pastore D, Greco M, Passarella S (2000) Specific helium-neon laser sensitivity of the purified cytochrome c oxidase. Int J Radiat Biol 76(6):863–870CrossRefPubMed
17.
go back to reference Sakurai Y, Yamaguchi M, Abiko Y (2000) Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 108(1):29–34CrossRefPubMed Sakurai Y, Yamaguchi M, Abiko Y (2000) Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 108(1):29–34CrossRefPubMed
19.
go back to reference de Lima FM, Villaverde AB, Albertini R, Correa JC, Carvalho RL, Munin E, Araujo T, Silva JA, Aimbire F (2011) Dual effect of low-level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: action on anti- and pro-inflammatory cytokines. Lasers Surg Med 43(5):410–420. https://doi.org/10.1002/lsm.21053 CrossRefPubMed de Lima FM, Villaverde AB, Albertini R, Correa JC, Carvalho RL, Munin E, Araujo T, Silva JA, Aimbire F (2011) Dual effect of low-level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: action on anti- and pro-inflammatory cytokines. Lasers Surg Med 43(5):410–420. https://​doi.​org/​10.​1002/​lsm.​21053 CrossRefPubMed
20.
go back to reference Satino JL, Markou M (2003) Hair regrowth and increased hair tensile strength using the HairMax LaserComb for low-level laser therapy. Int J Cosmet Surg Aesthet Dermatol 5(2):113–117CrossRef Satino JL, Markou M (2003) Hair regrowth and increased hair tensile strength using the HairMax LaserComb for low-level laser therapy. Int J Cosmet Surg Aesthet Dermatol 5(2):113–117CrossRef
21.
go back to reference Kim SS, Park MW, Lee CJ (2007) Phototherapy of androgenetic alopecia with low level narrow band 655-nm red ligth and 780nm infrared light. J Am Acad Dermatolog 56:AB112 American Academy of Dermatology 56th annual meeting CrossRef Kim SS, Park MW, Lee CJ (2007) Phototherapy of androgenetic alopecia with low level narrow band 655-nm red ligth and 780nm infrared light. J Am Acad Dermatolog 56:AB112 American Academy of Dermatology 56th annual meeting CrossRef
30.
go back to reference Esmat SM, Hegazy RA, Gawdat HI, Abdel Hay RM, Allam RS, El Naggar R, Moneib H (2017) Low level light-minoxidil 5% combination versus either therapeutic modality alone in management of female patterned hair loss: a randomized controlled study. Lasers Surg Med. https://doi.org/10.1002/lsm.22684 Esmat SM, Hegazy RA, Gawdat HI, Abdel Hay RM, Allam RS, El Naggar R, Moneib H (2017) Low level light-minoxidil 5% combination versus either therapeutic modality alone in management of female patterned hair loss: a randomized controlled study. Lasers Surg Med. https://​doi.​org/​10.​1002/​lsm.​22684
31.
go back to reference Barikbin B, Khodamrdi Z, Kholoosi L, Akhgri MR, Haj Abbasi M, Hajabbasi M, Razzaghi Z, Akbarpour S (2017) Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia. J Cosmet Laser Ther. https://doi.org/10.1080/14764172.2017.1326609 Barikbin B, Khodamrdi Z, Kholoosi L, Akhgri MR, Haj Abbasi M, Hajabbasi M, Razzaghi Z, Akbarpour S (2017) Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia. J Cosmet Laser Ther. https://​doi.​org/​10.​1080/​14764172.​2017.​1326609
35.
go back to reference Roberts JL, Fiedler V, Imperato-McGinley J, Whiting D, Olsen E, Shupack J, Stough D, DeVillez R, Rietschel R, Savin R, Bergfeld W, Swinehart J, Funicella T, Hordinsky M, Lowe N, Katz I, Lucky A, Drake L, Price VH, Weiss D, Whitmore E, Millikan L, Muller S, Gencheff C et al (1999) Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss. J Am Acad Dermatol 41(4):555–563PubMed Roberts JL, Fiedler V, Imperato-McGinley J, Whiting D, Olsen E, Shupack J, Stough D, DeVillez R, Rietschel R, Savin R, Bergfeld W, Swinehart J, Funicella T, Hordinsky M, Lowe N, Katz I, Lucky A, Drake L, Price VH, Weiss D, Whitmore E, Millikan L, Muller S, Gencheff C et al (1999) Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss. J Am Acad Dermatol 41(4):555–563PubMed
36.
go back to reference Berger RS, Fu JL, Smiles KA, Turner CB, Schnell BM, Werchowski KM, Lammers KM (2003) The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial. Br J Dermatol 149(2):354–362CrossRefPubMed Berger RS, Fu JL, Smiles KA, Turner CB, Schnell BM, Werchowski KM, Lammers KM (2003) The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial. Br J Dermatol 149(2):354–362CrossRefPubMed
37.
Metadata
Title
Low-level laser therapy for the treatment of androgenic alopecia: a review
Authors
Evan Darwin
Alexandra Heyes
Penelope A. Hirt
Tongyu Cao Wikramanayake
Joaquin J. Jimenez
Publication date
01-02-2018
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 2/2018
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-017-2385-5

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