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01-04-2015 | Original Article

InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

Authors: Helen Reinhart Camargo Catarino, Natália Pereira de Godoy, Nayara Kastem Scharlack, Lia Mara Grosso Neves, Fernanda Oliveira de Gaspari de Gaspi, Marcelo Augusto Marreto Esquisatto, Maria Esméria Corezola do Amaral, Fernanda Aparecida Sampaio Mendonça, Gláucia Maria Tech dos Santos

Published in: Lasers in Medical Science | Issue 3/2015

Abstract

Therapies that accelerate the healing of burn injuries, improving the quality of life of the patient and reducing the cost of treatment are important. This study evaluated the effects of InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis leaves on burn wound healing in rats. Seventy-two rats were divided randomly into four groups: control untreated (C), treated with InGaP 670-nm laser with power density of 0.41 W/cm² and energy density of 4.93 J/cm² (L), treated with S. chilensis extract (S) and treated with S. chilensis extract and laser (LS). Second-degree burns were produced on the back of the animals with metal plate. Wound samples were collected on days 7, 14 and 21 of treatment for structural analysis, morphometry and Western blotting to quantify the expression of transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). The results showed that InGaP laser irradiation at 670 nm alone and combined with extract of S. chilensis promoted significant tissue repair responses in this experimental model, increasing the number of fibroblasts, collagen fibres and newly formed blood vessels throughout the experimental period and decreasing the number of granulocytes in burn wounds of second degree in all treated groups. Exclusive treatment of burn wounds with the hydroalcoholic extract of S. chilensis provided similar quantitative results to those seen in the untreated group throughout the experimental period. Therefore, it was observed in the L and LS groups different responses in the expression of TGF-β1 and VEGF. The application of 670-nm laser alone or combined with the extract of S. chilensis promoted favourable responses in tissue repair of second-degree burns in this experimental model.

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Title: InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries
Authors: Helen Reinhart Camargo Catarino
Natália Pereira de Godoy
Nayara Kastem Scharlack
Lia Mara Grosso Neves
Fernanda Oliveira de Gaspari de Gaspi
Marcelo Augusto Marreto Esquisatto
Maria Esméria Corezola do Amaral
Fernanda Aparecida Sampaio Mendonça
Gláucia Maria Tech dos Santos
Publication date: 01-04-2015
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 3/2015
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1707-0

At a glance: The STEP trials

Springer Medicine

InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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