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01-09-2015 | Review Article

The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis

Authors: Romildo Torres-Silva, Rodrigo Alvaro Brandão Lopes-Martins, Jan Magnus Bjordal, Lucio Frigo, Rachid Rahouadj, Gilles Arnold, Ernesto Cesar Pinto Leal-Junior, Jacques Magdalou, Rodney Pallotta, Rodrigo Labat Marcos

Published in: Lasers in Medical Science | Issue 7/2015

Abstract

Tendinopathy is a common disease with a variety of treatments and therapies. Laser therapy appears as an alternative treatment. Here, we investigate the effects of laser irradiation in an experimental model of tendinitis induced by collagenase injection on rats’ Achilles tendon, verifying its action in important inflammatory markers. Male Wistar rats were used and divided into five groups: control saline (C), non-treated tendinitis (NT) and tendinitis treated with sodium diclofenac (D) or laser (1 J) and (3 J). The tendinitis was induced by collagenase (100 μg/tendon) on the Achilles tendon, which was removed for further analyses. The gene expression for COX-2; TNF-α; IL-6; and IL-10 (RT-PCR) was measured. The laser irradiation (660 nm, 100 mW, 3 J) used in the treatment of the tendinitis induced by collagenase in Achilles tendon in rats was effective in the reduction of important pro-inflammatory markers such as IL-6 and TNF-α, becoming a promising tool for the treatment of tendon diseases.

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Title: The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis
Authors: Romildo Torres-Silva
Rodrigo Alvaro Brandão Lopes-Martins
Jan Magnus Bjordal
Lucio Frigo
Rachid Rahouadj
Gilles Arnold
Ernesto Cesar Pinto Leal-Junior
Jacques Magdalou
Rodney Pallotta
Rodrigo Labat Marcos
Publication date: 01-09-2015
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 7/2015
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1676-3

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The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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