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Lasers in Medical Science
Published in: Lasers in Medical Science 2/2009

01-03-2009 | Original Article

Possible roles of mast cell-derived chymase for skin rejuvenation

Authors: Nobuyuki Amano, Shinji Takai, Denan Jin, Koichi Ueda, Mizuo Miyazaki

Published in: Lasers in Medical Science | Issue 2/2009

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Abstract

The relationships between mast cell-derived chymase, angiotensin II, and extracellular matrix production in the skin after intense pulsed light (IPL) were clarified in hamsters. Dorsal areas of the hamsters were irradiated once or twice a week by IPL. The index of extracellular matrix production in the skin was defined as the depth stained with Azan-Mallory stain from the epidermis to the dermis at the point of maximum thickness. The index had significantly increased 7 days after IPL irradiation in sections treated once or twice with IPL compared with that of untreated control sections. The numbers of mast cells, chymase-positive cells, and angiotensin II-positive cells had also significantly increased in IPL-irradiated areas. Significant increases in chymase and angiotensin II activities were observed in the extracts obtained from IPL-irradiated skin. Mast cell-derived chymase may be involved via angiotensin II formation in the dermal extracellular matrix production that occurs after IPL irradiation.
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Metadata
Title
Possible roles of mast cell-derived chymase for skin rejuvenation
Authors
Nobuyuki Amano
Shinji Takai
Denan Jin
Koichi Ueda
Mizuo Miyazaki
Publication date
01-03-2009
Publisher
Springer-Verlag
Published in
Lasers in Medical Science / Issue 2/2009
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-008-0558-y

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