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European Journal of Clinical Microbiology & Infectious Diseases

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01-05-2021 | Metronidazole | Brief Report

Whole genome sequencing to decipher the virulence phenotype of hypervirulent Klebsiella pneumoniae responsible for liver abscess, Marseille, France

Authors: Sophie Alexandra Baron, Léa-Marie Pascale, Matthieu Million, Antoine Briantais, Jean-Marc Durand, Linda Hadjadj, Jean-Marc Rolain

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 5/2021

Abstract

We described three clinical cases of pyogenic liver abscess caused by hypervirulent Klebsiella pneumoniae (hvKp) successfully treated by prolonged antibiotherapy, in which one case was complicated by endophthalmitis. Whole genome sequencing helped to confirm the diagnosis of these hvKp strains, which belong to clonal complexes CC86 and CC23 and carried hvKp-associated genes (magA and/or rmpA). This syndrome is increasingly reported in France and Europe and raises questions about the source of infection.

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Title: Whole genome sequencing to decipher the virulence phenotype of hypervirulent Klebsiella pneumoniae responsible for liver abscess, Marseille, France
Authors: Sophie Alexandra Baron
Léa-Marie Pascale
Matthieu Million
Antoine Briantais
Jean-Marc Durand
Linda Hadjadj
Jean-Marc Rolain
Publication date: 01-05-2021
Publisher: Springer Berlin Heidelberg
Keyword: Metronidazole
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 5/2021
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-020-04080-7

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