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European Journal of Clinical Microbiology & Infectious Diseases

Published in:

01-11-2015 | Review

Rapid molecular diagnostic tests in patients with bacteremia: evaluation of their impact on decision making and clinical outcomes

Authors: K. Z. Vardakas, F. I. Anifantaki, K. K. Trigkidis, M. E. Falagas

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 11/2015

Abstract

We performed a systematic review of the data regarding rapid diagnostic tests and their advantages or limitations on patients’ clinical outcomes. The PubMed and Scopus databases were searched independently by two reviewers. Mortality was the primary outcome. Most studies compared rapid tests with blood cultures. Although not observed in all studies, only studies comparing rapid tests in conjunction with antimicrobial stewardship programs (ASPs) showed a mortality benefit. A reduction in hospital or intensive care unit (ICU) length of stay was also observed in almost all studies when the rapid tests, with or without ASPs, were used. Finally, treatment decisions were taken earlier in the rapid test groups. Despite a faster treatment decision, a clear mortality benefit was not seen when rapid tests were used. It is crucial to differentiate the influence of rapid tests from that of ASPs and clarify the actual effect of each factor separately.

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Title: Rapid molecular diagnostic tests in patients with bacteremia: evaluation of their impact on decision making and clinical outcomes
Authors: K. Z. Vardakas
F. I. Anifantaki
K. K. Trigkidis
M. E. Falagas
Publication date: 01-11-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 11/2015
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-015-2466-y

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