Skip to main content
Top
Published in: European Journal of Clinical Microbiology & Infectious Diseases 8/2014

01-08-2014 | Article

Are hip hemiarthroplasty and total hip arthroplasty infections different entities? The importance of hip fractures

Authors: M. D. del Toro, I. Nieto, F. Guerrero, J. Corzo, A. del Arco, J. Palomino, E. Nuño, J. M. Lomas, C. Natera, J. M. Fajardo, J. Delgado, M. Torres-Tortosa, A. Romero, P. Martín-Rico, M. Á. Muniain, J. Rodríguez-Baño, for the PJIG-SAEI/REIPI group

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 8/2014

Login to get access

Abstract

Hip hemiarthroplasty (HHA) and total hip arthroplasty (THA) infections are usually considered as one entity; however, they may show important differences. We analyze these differences, as well as predictors of treatment failure (TF) and poor functional status among patients with prosthetic hip infections (PHIs). A multicenter cohort study of consecutive patients with PHIs was performed. The main outcome variable was TF after the first surgical treatment performed to treat the infection. Multivariate analysis was used to identify predictors of TF. A total of 127 patients with PHI were included (43 HHA, 84 THA). Patients with HHA infections were more frequently women (88 % vs. 54 %; p < 0.001), had comorbidities (86 % vs. 67 %, p = 0.02), and were older (median age 79 vs. 65 years, p < 0.001), and the reason for arthroplasty was more frequently a fracture (100 % vs. 18 %, p < 0.001). Failure of initial treatment and crude mortality were more frequent among HHA patients (44 % vs. 23 %, p = 0.01 and 28 % vs. 7 %, p = 0.001, respectively). However, HHA was not associated with TF in the multivariate analysis when hip fracture was considered; thus, variables independently associated with TF were hip fracture, inadequate surgical management, prosthesis retention, and higher C-reactive protein level. Failure of the first surgical treatment was associated with poorer functional status. HHA and THA infections showed significant differences in epidemiology, clinical features, and outcome. Although patients with HHA infections had a higher risk of TF, this was related to the reason for hip implant: a hip fracture. Success of the initial management of infection is a predictor of better clinical and functional outcome.
Literature
1.
2.
go back to reference Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J (2008) Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty 23:984–991PubMedCrossRef Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J (2008) Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty 23:984–991PubMedCrossRef
4.
go back to reference De Laet CE, Pols HA (2000) Fractures in the elderly: epidemiology and demography. Baillieres Best Pract Res Clin Endocrinol Metab 14:171–179PubMedCrossRef De Laet CE, Pols HA (2000) Fractures in the elderly: epidemiology and demography. Baillieres Best Pract Res Clin Endocrinol Metab 14:171–179PubMedCrossRef
6.
go back to reference Pollard TC, Newman JE, Barlow NJ, Price JD, Willett KM (2006) Deep wound infection after proximal femoral fracture: consequences and costs. J Hosp Infect 63:133–139PubMedCrossRef Pollard TC, Newman JE, Barlow NJ, Price JD, Willett KM (2006) Deep wound infection after proximal femoral fracture: consequences and costs. J Hosp Infect 63:133–139PubMedCrossRef
7.
go back to reference Wilson J, Ramboer I, Suetens C; HELICS-SSI working group (2007) Hospitals in Europe Link for Infection Control through Surveillance (HELICS). Inter-country comparison of rates of surgical site infection—opportunities and limitations. J Hosp Infect 65:165–170PubMedCrossRef Wilson J, Ramboer I, Suetens C; HELICS-SSI working group (2007) Hospitals in Europe Link for Infection Control through Surveillance (HELICS). Inter-country comparison of rates of surgical site infection—opportunities and limitations. J Hosp Infect 65:165–170PubMedCrossRef
8.
go back to reference García-Alvarez F, Al-Ghanem R, García-Alvarez I, López-Baisson A, Bernal M (2010) Risk factors for postoperative infections in patients with hip fracture treated by means of Thompson arthroplasty. Arch Gerontol Geriatr 50:51–55PubMedCrossRef García-Alvarez F, Al-Ghanem R, García-Alvarez I, López-Baisson A, Bernal M (2010) Risk factors for postoperative infections in patients with hip fracture treated by means of Thompson arthroplasty. Arch Gerontol Geriatr 50:51–55PubMedCrossRef
9.
go back to reference Acklin YP, Widmer AF, Renner RM, Frei R, Gross T (2011) Unexpectedly increased rate of surgical site infections following implant surgery for hip fractures: problem solution with the bundle approach. Injury 42:209–216PubMedCrossRef Acklin YP, Widmer AF, Renner RM, Frei R, Gross T (2011) Unexpectedly increased rate of surgical site infections following implant surgery for hip fractures: problem solution with the bundle approach. Injury 42:209–216PubMedCrossRef
10.
go back to reference Edwards C, Counsell A, Boulton C, Moran CG (2008) Early infection after hip fracture surgery: risk factors, costs and outcome. J Bone Joint Surg Br 90:770–777PubMedCrossRef Edwards C, Counsell A, Boulton C, Moran CG (2008) Early infection after hip fracture surgery: risk factors, costs and outcome. J Bone Joint Surg Br 90:770–777PubMedCrossRef
11.
go back to reference Partanen J, Syrjälä H, Vähänikkilä H, Jalovaara P (2006) Impact of deep infection after hip fracture surgery on function and mortality. J Hosp Infect 62:44–49PubMedCrossRef Partanen J, Syrjälä H, Vähänikkilä H, Jalovaara P (2006) Impact of deep infection after hip fracture surgery on function and mortality. J Hosp Infect 62:44–49PubMedCrossRef
12.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383PubMedCrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383PubMedCrossRef
13.
go back to reference Charlson M, Szatrowski TP, Peterson J, Gold J (1994) Validation of a combined comorbidity index. J Clin Epidemiol 47(11):1245–1251PubMedCrossRef Charlson M, Szatrowski TP, Peterson J, Gold J (1994) Validation of a combined comorbidity index. J Clin Epidemiol 47(11):1245–1251PubMedCrossRef
14.
go back to reference Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR; Infectious Diseases Society of America (2013) Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 56(1):e1–e25PubMedCrossRef Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR; Infectious Diseases Society of America (2013) Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 56(1):e1–e25PubMedCrossRef
15.
go back to reference Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR (1999) Guideline for prevention of surgical site infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control 27:97–132PubMedCrossRef Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR (1999) Guideline for prevention of surgical site infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control 27:97–132PubMedCrossRef
16.
go back to reference Alvarez-Nebreda ML, Jiménez AB, Rodríguez P, Serra JA (2008) Epidemiology of hip fracture in the elderly in Spain. Bone 42:278–285PubMedCrossRef Alvarez-Nebreda ML, Jiménez AB, Rodríguez P, Serra JA (2008) Epidemiology of hip fracture in the elderly in Spain. Bone 42:278–285PubMedCrossRef
17.
go back to reference Albaba M, Cha SS, Takahashi PY (2012) The Elders Risk Assessment Index, an electronic administrative database-derived frailty index, can identify risk of hip fracture in a cohort of community-dwelling adults. Mayo Clin Proc 87:652–658PubMedCentralPubMedCrossRef Albaba M, Cha SS, Takahashi PY (2012) The Elders Risk Assessment Index, an electronic administrative database-derived frailty index, can identify risk of hip fracture in a cohort of community-dwelling adults. Mayo Clin Proc 87:652–658PubMedCentralPubMedCrossRef
18.
go back to reference Smith GH, Tsang J, Molyneux SG, White TO (2011) The hidden blood loss after hip fracture. Injury 42:133–135PubMedCrossRef Smith GH, Tsang J, Molyneux SG, White TO (2011) The hidden blood loss after hip fracture. Injury 42:133–135PubMedCrossRef
19.
go back to reference Saleh K, Olson M, Resig S, Bershadsky B, Kuskowski M, Gioe T, Robinson H, Schmidt R, McElfresh E (2002) Predictors of wound infection in hip and knee joint replacement: results from a 20 year surveillance program. J Orthop Res 20:506–515PubMedCrossRef Saleh K, Olson M, Resig S, Bershadsky B, Kuskowski M, Gioe T, Robinson H, Schmidt R, McElfresh E (2002) Predictors of wound infection in hip and knee joint replacement: results from a 20 year surveillance program. J Orthop Res 20:506–515PubMedCrossRef
20.
go back to reference Cheung EV, Sperling JW, Cofield RH (2008) Infection associated with hematoma formation after shoulder arthroplasty. Clin Orthop Relat Res 466:1363–1367PubMedCentralPubMedCrossRef Cheung EV, Sperling JW, Cofield RH (2008) Infection associated with hematoma formation after shoulder arthroplasty. Clin Orthop Relat Res 466:1363–1367PubMedCentralPubMedCrossRef
21.
go back to reference Moran E, Masters S, Berendt AR, McLardy-Smith P, Byren I, Atkins BL (2007) Guiding empirical antibiotic therapy in orthopaedics: The microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention. J Infect 55:1–7PubMedCrossRef Moran E, Masters S, Berendt AR, McLardy-Smith P, Byren I, Atkins BL (2007) Guiding empirical antibiotic therapy in orthopaedics: The microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention. J Infect 55:1–7PubMedCrossRef
22.
go back to reference Rodríguez-Baño J, del Toro MD, Lupión C, Suárez AI, Silva L, Nieto I, Muniain MA (2008) Arthroplasty-related infection: incidence, risk factors, clinical features, and outcome. Enferm Infecc Microbiol Clin 26:614–620PubMedCrossRef Rodríguez-Baño J, del Toro MD, Lupión C, Suárez AI, Silva L, Nieto I, Muniain MA (2008) Arthroplasty-related infection: incidence, risk factors, clinical features, and outcome. Enferm Infecc Microbiol Clin 26:614–620PubMedCrossRef
23.
go back to reference Betsch BY, Eggli S, Siebenrock KA, Täuber MG, Mühlemann K (2008) Treatment of joint prosthesis infection in accordance with current recommendations improves outcome. Clin Infect Dis 46:1221–1226PubMedCrossRef Betsch BY, Eggli S, Siebenrock KA, Täuber MG, Mühlemann K (2008) Treatment of joint prosthesis infection in accordance with current recommendations improves outcome. Clin Infect Dis 46:1221–1226PubMedCrossRef
24.
go back to reference Giulieri SG, Graber P, Ochsner PE, Zimmerli W (2004) Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection 32:222–228PubMedCrossRef Giulieri SG, Graber P, Ochsner PE, Zimmerli W (2004) Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection 32:222–228PubMedCrossRef
25.
go back to reference Laffer RR, Graber P, Ochsner PE, Zimmerli W (2006) Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre. Clin Microbiol Infect 12:433–439PubMedCrossRef Laffer RR, Graber P, Ochsner PE, Zimmerli W (2006) Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre. Clin Microbiol Infect 12:433–439PubMedCrossRef
26.
go back to reference Salgado CD, Dash S, Cantey JR, Marculescu CE (2007) Higher risk of failure of methicillin-resistant Staphylococcus aureus prosthetic joint infections. Clin Orthop Relat Res 461:48–53PubMed Salgado CD, Dash S, Cantey JR, Marculescu CE (2007) Higher risk of failure of methicillin-resistant Staphylococcus aureus prosthetic joint infections. Clin Orthop Relat Res 461:48–53PubMed
27.
go back to reference Berbari EF, Osmon DR, Duffy MC, Harmssen RN, Mandrekar JN, Hanssen AD, Steckelberg JM (2006) Outcome of prosthetic joint infection in patients with rheumatoid arthritis: the impact of medical and surgical therapy in 200 episodes. Clin Infect Dis 42:216–223PubMedCrossRef Berbari EF, Osmon DR, Duffy MC, Harmssen RN, Mandrekar JN, Hanssen AD, Steckelberg JM (2006) Outcome of prosthetic joint infection in patients with rheumatoid arthritis: the impact of medical and surgical therapy in 200 episodes. Clin Infect Dis 42:216–223PubMedCrossRef
28.
go back to reference Yu L, Wang Y, Chen J (2012) Total hip arthroplasty versus hemiarthroplasty for displaced femoral neck fractures: meta-analysis of randomized trials. Clin Orthop Relat Res 470(8):2235–2243PubMedCentralPubMedCrossRef Yu L, Wang Y, Chen J (2012) Total hip arthroplasty versus hemiarthroplasty for displaced femoral neck fractures: meta-analysis of randomized trials. Clin Orthop Relat Res 470(8):2235–2243PubMedCentralPubMedCrossRef
Metadata
Title
Are hip hemiarthroplasty and total hip arthroplasty infections different entities? The importance of hip fractures
Authors
M. D. del Toro
I. Nieto
F. Guerrero
J. Corzo
A. del Arco
J. Palomino
E. Nuño
J. M. Lomas
C. Natera
J. M. Fajardo
J. Delgado
M. Torres-Tortosa
A. Romero
P. Martín-Rico
M. Á. Muniain
J. Rodríguez-Baño
for the PJIG-SAEI/REIPI group
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 8/2014
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-014-2091-1

Other articles of this Issue 8/2014

European Journal of Clinical Microbiology & Infectious Diseases 8/2014 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.