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European Journal of Clinical Microbiology & Infectious Diseases

Published in:

01-01-2005 | Concise Article

Use of convalescent plasma therapy in SARS patients in Hong Kong

Authors: Y. Cheng, R. Wong, Y. O. Y. Soo, W. S. Wong, C. K. Lee, M. H. L. Ng, P. Chan, K. C. Wong, C. B. Leung, G. Cheng

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 1/2005

Abstract

In order to evaluate the efficacy of convalescent plasma therapy in the treatment of patients with severe acute respiratory syndrome (SARS), 80 SARS patients were given convalescent plasma at Prince of Wales Hospital, Hong Kong, between 20 March and 26 May 2003. Good outcome was defined as discharge by day 22 following the onset of SARS symptoms. Poor outcome was defined as death or hospitalization beyond 22 days. A higher day-22 discharge rate was observed among patients who were given convalescent plasma before day 14 of illness (58.3% vs 15.6%; P<0.001) and among those who were PCR positive and seronegative for coronavirus at the time of plasma infusion (66.7% vs 20%; P=0.001).

Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ, SARS Working Group (2003) A novel coronavirus-associated severe acute respiratory syndrome. N Engl J Med 348:1953–1966CrossRefPubMed

Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW (2003) Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348:1967–1976CrossRefPubMed

Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY, SARS Study Group (2003) Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361:1319–1325CrossRef

Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC, Chung S, Sung JJ (2003) A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 348:1986–1994CrossRefPubMed

Stinebaugh BJ, Schloeder FX, Johnson KM, Mackenzie RB, Entwisle G, De Alba E (1966) Bolivian hemorrhagic fever. A report of four cases. Am J Med 40:217–230CrossRef

Ruggiero HA, Perez Isquierdo F, Milani HA, Barri A, Val A, Maglio F, Astarloa L, Gonzalez Cambaceres C, Milani HL, Tallone JC (1986) Treatment of Argentine hemorrhagic fever with convalescent’s plasma 4433 cases [in French]. Presse Med 15:2239–2242

Frame JD, Verbrugge GP, Gill RG, Pinneo L (1984) The use of Lassa fever convalescent plasma in Nigeria. Trans R Soc Trop Med Hyg 78:319–324CrossRef

Mupapa K, Massamba M, Kibadi K, Kuvula K, Bwaka A, Kipasa M, Colebunders R, Muyembe-Tamfum JJ (1999) Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee. J Infect Dis 179(suppl 1):18–23

Ben-Nathan D, Lustig S, Tam G, Robinzon S, Segal S, Rager-Zisman B (2003) Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treatment of West Nile virus infection in mice. J Infect Dis 188:1–4CrossRef

10.

Solomon T, Ooi MH, Beasley DW, Mallewa M (2003) West Nile encephalitis. Br Med J 326:865–869

11.

Centers for Disease Control and Prevention (2003). Update: severe acute respiratory syndrome. Morb Mortal Wkly Rep 52:388–390

12.

Peiris JS, Chu CM, Cheng VC, Chan KS, Hung IF, Poon LL, Law KI, Tang BS, Hon TY, Chan CS, Chan KH, Ng JS, Zheng BJ, Ng WL, Lai RW, Guan Y, Yuen KY, HKU/UCH SARS Study Group (2003) Prospective study of the clinical progression and viral load of SARS-associated coronavirus pneumonia in a community outbreak. Lancet 361:1767–1772CrossRefPubMed

Title: Use of convalescent plasma therapy in SARS patients in Hong Kong
Authors: Y. Cheng
R. Wong
Y. O. Y. Soo
W. S. Wong
C. K. Lee
M. H. L. Ng
P. Chan
K. C. Wong
C. B. Leung
G. Cheng
Publication date: 01-01-2005
Publisher: Springer-Verlag
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 1/2005
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-004-1271-9

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