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European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 7/2004

01-07-2004 | Concise Article

Mollaret’s meningitis caused by herpes simplex virus type 2: case report and literature review

Authors: J. S. Dylewski, S. Bekhor

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 7/2004

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Abstract

Presented here is a new case of benign recurrent aseptic meningitis, or Mollaret’s meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain reaction test. A search of the existing medical literature revealed 58 previously reported cases of Mollaret’s meningitis in which samples of cerebrospinal fluid were tested for herpes simplex virus. Discussed here are the history, clinical and laboratory findings, differential diagnoses and therapeutic options for this illness.
Literature
1.
Mollaret P (1944) La méningite endothélio-leukocytaire multirécurrente bénigne: syndrome nouveau ou maladie nouvelle? Rev Neurol (Paris) 76:57–76
2.
Yamamoto LJ, Tedder DG, Ashley R, Levin MJ (1991) Herpes simplex virus type 1 DNA in cerebrospinal fluid of a patient with Mollaret’s meningitis. N Engl J Med 325:1082–1085PubMed
3.
Picard FJ, Dekaban GA, Silva J, Rice GP (1993) Mollaret’s meningitis associated with herpes simplex type 2 infection. Neurology 43:1722–1727PubMed
4.
Cohen BA, Rowley A, Long CM (1994) Herpes simplex type 2 in a patient with Mollaret’s meningitis: Demonstration by polymerase chain reaction. Ann Neurol 35:112–116PubMed
5.
Tedder DG, Ashley R, Tyler KL, Levin MJ (1994) Herpes simplex virus infection as a cause of benign recurrent lymphocytic meningitis. Ann Intern Med 121:334–338PubMed
6.
Bachmeyer C, de la Blanchardiere A, Lepercq J et al (1996) Recurring episodes of meningitis (Mollaret’s meningitis) with one showing an association with herpes simplex virus type 2. J Infect 32:247–248CrossRefPubMed
7.
Jensensius M, Myrvang B, Storvold G, Bucher A, Hellum KB, Bruu AL (1998) Herpes simplex virus type 2 DNA detected in cerebrospinal fluid of 9 patients with Mollaret’s meningitis. Acta Neurol Scand 98:209–212PubMed
8.
Gignoux L, Ryvlin P, Najioullah F, Maugiere F (1998) Recurrent Mollaret’s meningitis of herpetic origin. Presse Medicale 27:1470–1472
9.
Tang YW, Cleavinger PJ, Li H, Mitchell PS, Smith TF, Persing DH (2000) Analysis of candidate-host immunogenetic determinants in herpes simplex virus-associated Mollaret’s meningitis. Clin Infect Dis 30:176–178CrossRefPubMed
10.
Kojima Y, Hashiguchi H, Hashimoto T, Tsuji S, Shoji H, Kazuyama Y (2002) Recurrent herpes simplex virus type 2 meningitis: a case report of Mollaret’s meningitis. Jpn J Infect Dis 55:85–88PubMed
11.
Johnson G, Nelson S, Petric M, Tellier R (2000) Comprehensive PCR-based assay for detection and species identification of human herpesviruses. J Clin Microbiol 38:3274–3279PubMed
12.
Chan TY, Parwani AV, Levi AW, Ali SZ (2003) Mollaret’s meningitis: cytopathologic analysis of fourteen cases. Diagn Cytopathol 28:227–231CrossRefPubMed
13.
Bruyn GW, Staathof LJA, Raymakers GMJ (1962) Mollaret’s meningitis: differential diagnosis and diagnostic pitfalls. Neurology (Minn) 12:745–753
14.
Hermans PE, Goldstein NP, Wellman WE (1972) Mollaret’s meningitis and differential diagnosis of recurrent meningitis. Report of case, with review of the literature. Am J Med 52:128–140CrossRefPubMed
15.
Hendler N, Schlaeffer F, Zirkin H, Rabinowitz B, Berginer VM (1991) Mollaret’s meningitis in association with delivery in a Bedouin woman; a case report. Eur J Obstet Gynecol Reprod Biol 39:77–79PubMed
16.
Lee CT, Chao CH, Yu KW, Liu CY (1992) Mollaret’s meningitis: case report and literature review. Chung Hua I Hsueh Tsa Chih 49:289–293PubMed
17.
Rottach K, Scheglmann K, Pfadenhauer K (1996) Mollaret’s meningitis: a new etiologic feature. Eur Neurol 36:172–173PubMed
18.
Monteyene P, Sindic CJM, Laterre EC (1996) Recurrent meningitis and encephalitis associated with herpes simplex type 2: demonstration by polymerase chain reaction. Eur Neurol 36:176–177PubMed
19.
Aristegui FJ, Delgado RA, Oleaga ZL, Hermosa CC (1998) Mollaret’s recurrent aseptic meningitis and cerebral epidermoid cyst. Pediatr Neurol 18:156–159CrossRefPubMed
20.
Berger JR (1991) Benign aseptic (Mollaret’s) meningitis after genital herpes. Lancet 337:1360–1361CrossRef
21.
Graman PS (1987) Mollaret’s meningitis associated with acute Epstein-Barr virus mononucleosis. Arch Neurol 44:1204–1205PubMed
22.
Steel JG, Dix RD, Baringer JR (1981) Isolation of herpes simplex type 1 in recurrent (Mollaret’s) meningitis. Trans Am Neurol Assoc 106:37–42PubMed
23.
Bergstrom T, Vahlne A, Alestig K, Jeansson S, Forsgren M, Lycke E (1990) Primary and recurrent herpes simplex virus type 2-induced meningitis. J Infect Dis 162:322–330PubMed
24.
Teot LA, Sexton CW (1996) Mollaret’s meningitis: case report with immunocytochemical and polymerase chain reaction amplification studies. Diagn Cytopathol 15:345–348CrossRefPubMed
25.
26.
Mora JS, Gimeno A (1980) Mollaret meningitis: report of a case with recovery after colchicine. Ann Neurol 8:631–633PubMed
27.
Stamm AM, Livingston WK, Cobbs CG, Dismukes WE (1984) Failure of colchicine in the treatment of Mollaret’s meningitis. Arch Intern Med 144:2265–2266CrossRefPubMed
28.
Lycke J, Malmeström C, Stähle L (2003) Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother 47:2438–2441CrossRefPubMed
Metadata
Title
Mollaret’s meningitis caused by herpes simplex virus type 2: case report and literature review
Authors
J. S. Dylewski
S. Bekhor
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 7/2004
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-004-1164-y

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