Top

Published in:

03-08-2022 | Stroke | Brief Communication

Carotid free-floating thrombus during COVID-19 vaccine era: causality or not?

Authors: Ludovica Ferraù, Masina Cotroneo, Cristina Dell’Aera, Fabrizio Giammello, Francesco Grillo, Teresa Brizzi, Antonio Pitrone, Sergio Lucio Vinci, Rosa Fortunata Musolino, Paolino La Spina

Published in: Neurological Sciences | Issue 11/2022

Abstract

Carotid free-floating thrombus (FFT) is very rarely diagnosed in patients with acute ischemic stroke. It is a real clinical emergency due to the significant risk of death associated with thromboembolic complications. Herein, we present three patients with ischemic stroke caused by carotid FFT after less than 20 days from administration of mRNA vaccine BNT162b1 (Pfizer/BioNTech) for Severe Acute Respiratory Syndrome—CoronaVirus 2 (SARS-CoV-2). To our knowledge, these are the first cases reporting carotid FTT following SARS-CoV-2 vaccination.

Available only for authorised users

Chua H, Lim T, Teo B, Phua Z, Eng J (2012) Free-floating thrombus of the carotid artery detected on carotid ultrasound in patients with cerebral infarcts: a 10-year study - PubMed. Ann Acad Med Singap 41:420–424PubMed

Kim JG, Lee SJ (2015) Two cases with free - floating thrombus in the common carotid artery. J Cardiol Clin Res 3:1047

Bhatti AF et al (2007) Free-floating thrombus of the carotid artery: literature review and case reports. J Vasc Surg 45:199–205CrossRefPubMed

Renard D, Heroum C (2007) Carotid thrombus formation and extension during anticoagulation: a case report of large vessel disease and hypercoagulable state in systemic sclerosis. Acta Neurol Belg 107:55–57PubMed

Cancer-Perez S et al (2021) Symptomatic common carotid free-floating thrombus in a COVID-19 patient, case report and literature review. Ann Vasc Surg 73:122–128CrossRefPubMedPubMedCentral

Tobaiqy M, MacLure K, Elkout H, Stewart D (2021) Thrombotic Adverse Events Reported for Moderna, Pfizer and Oxford-AstraZeneca COVID-19 Vaccines: Comparison of Occurrence and Clinical Outcomes in the EudraVigilance Database. Vaccines (Basel) 9(11):1326. https://doi.org/10.3390/vaccines9111326CrossRef

Cari L, Fiore P, Naghavi Alhosseini M, Sava G, Nocentini G (2021) Blood clots and bleeding events following BNT162b2 and ChAdOx1 nCoV-19 vaccine: an analysis of European data. J Autoimmun 122. https://doi.org/10.1016/j.jautCrossRefPubMedPubMedCentral

Sánchez Van Kammen M et al (2021) Characteristics and outcomes of patients with cerebral venous sinus thrombosis in SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. JAMA Neurol. 78:1314–1323CrossRefPubMed

Cines DB, Bussel JB (2021) SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. N Engl J Med 384:2254–2256CrossRefPubMed

10.

Hippisley-Cox J, Patone M, Mei XW, Saatci D, Dixon S, Khunti K, Zaccardi F, Watkinson P, Shankar-Hari M, Doidge J, Harrison DA, Griffin SJ, Sheikh A (2021) Coupland CAC. Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. BMJ 374:1931.https://doi.org/10.1136/bmj.n1931

11.

Cascio Rizzo A, Giussani G, Agostoni EC (2022) Ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia following COVID-19 vaccine: a case report with systematic review of the literature. Cerebrovasc Dis 1 . https://doi.org/10.1159/000524290

Title: Carotid free-floating thrombus during COVID-19 vaccine era: causality or not?
Authors: Ludovica Ferraù
Masina Cotroneo
Cristina Dell’Aera
Fabrizio Giammello
Francesco Grillo
Teresa Brizzi
Antonio Pitrone
Sergio Lucio Vinci
Rosa Fortunata Musolino
Paolino La Spina
Publication date: 03-08-2022
Publisher: Springer International Publishing
Keywords: Stroke
COVID-19 Vaccination
Vaccination
SARS-CoV-2
Carotid Endarterectomy
CT Angiography
Published in: Neurological Sciences / Issue 11/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06307-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Carotid free-floating thrombus during COVID-19 vaccine era: causality or not?

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 11/2022

Correction to: Electroencephalographic alpha oscillation as first manifestation of brain restoration after resuscitation

GM2 gangliosidosis AB variant: first case of late onset and review of the literature

Painful legs and moving toes syndrome associated with dementia with Lewy bodies responsive to rotigotine-induced analgesia

Muscle and skin fibroblast TDP-43 expression, dynamic mutation analysis of NOTCH2NLC and C9orf72 in patients with FOSMN

Hyperbaric oxygen therapy to reverse post-COVID cognitive impairment

Diagnosis, treatment, and follow-up of patients with cerebral amyloid angiopathy-related inflammation