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Neurological Sciences
Published in: Neurological Sciences 9/2022

Open Access 08-07-2022 | Migraine | Review Article

The putative role of trigemino-vascular system in brain perfusion homeostasis and the significance of the migraine attack

Authors: Roberto De Simone, Mattia Sansone, Cinzia Russo, Angelo Miele, Antonio Stornaiuolo, Simone Braca

Published in: Neurological Sciences | Issue 9/2022

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Abstract

Besides representing the place where a migraine attack generates, what is the physiological role of peptidergic control of arteriolar caliber within the trigemino-vascular system? Considering that the shared goal of most human CGRP-based neurosensory systems is the protection from an acute threat, especially if hypoxic, what is the end meaning of a migraine attack? In this paper, we have reviewed available evidence on the possible role of the trigemino-vascular system in maintaining cerebral perfusion pressure homeostasis, despite the large physiological fluctuations in intracranial pressure occurring in daily life activities. In this perspective, the migraine attack is presented as the response to a cerebral hypoxic threat consequent to a deranged intracranial pressure control aimed at generating a temporary withdrawal from the environment with limitation of physical activity, a condition required to promote the restoration of cerebral fluids dynamic balance.
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Metadata
Title
The putative role of trigemino-vascular system in brain perfusion homeostasis and the significance of the migraine attack
Authors
Roberto De Simone
Mattia Sansone
Cinzia Russo
Angelo Miele
Antonio Stornaiuolo
Simone Braca
Publication date
08-07-2022
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 9/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-022-06200-x

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