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Neurological Sciences
Published in: Neurological Sciences 8/2022

Open Access 01-04-2022 | Cerebral Small Vessel Disease | Original Article

Coexistent cerebral small vessel disease and multiple infarctions predict recurrent stroke

Authors: Yu Tian, Yuesong Pan, Hongyi Yan, Xia Meng, XingQuan Zhao, Liping Liu, Yongjun Wang, Yilong Wang

Published in: Neurological Sciences | Issue 8/2022

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Abstract

Background and purpose

To investigate the association of different status of cerebral small vessel disease (CSVD) and infarction number with recurrence after acute minor stroke and transient ischaemic attack (TIA).

Methods

This study was a post hoc analysis of the Clopidogrel in High-risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial, and includes 886 patients with acute minor stroke and TIA. The status of CSVD and infarction number was recorded for each individual. Infarction number were classified as multiple acute infarctions (MAIs≥2), single acute infarction (SAI =1), and non-acute infarction (NAI =0). The CSVD burden were grouped into non-CSVD (0 score) and CSVD (1–4 score). The primary outcome was a recurrent stroke at the 1-year follow-up. The secondary outcomes were recurrent ischaemic stroke, composite vascular event (CVE), and TIA. We analyzed the relationships between different status of CSVD burden and infarction pattern with the risk of outcomes using multivariable Cox regression models.

Results

Among all 886 patients included in present analysis, recurrent stroke was occurred in 93 (10.5%) patients during 1-year follow-up. After adjusted for all potential covariates, compared with patients with non-CSVD and NAI, patients with CSVD and MAIs were associated with approximately 9.5-fold increased risk of recurrent stroke at 1 year (HR 9.560, 95% CI 1.273–71.787, p=0.028). Similar results observed in ischaemic stroke and CVE.

Conclusion

The status of CSVD and infarction number predicted recurrent stroke in patients with acute minor stroke and TIA, especially for those with coexistent CSVD and MAIs.
Appendix
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Metadata
Title
Coexistent cerebral small vessel disease and multiple infarctions predict recurrent stroke
Authors
Yu Tian
Yuesong Pan
Hongyi Yan
Xia Meng
XingQuan Zhao
Liping Liu
Yongjun Wang
Yilong Wang
Publication date
01-04-2022
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 8/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-022-06027-6

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