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28-02-2022 | Trigeminal Neuralgia | Original Article

The role of biomarkers in drug-resistant trigeminal neuralgia: a prospective study in patients submitted to surgical treatment

Authors: Alessandro Rapisarda, Silvia Baroni, Vanessa Gentili, Giacomo Moretti, Benedetta Burattini, Francesca Sarlo, Alessandro Olivi, Andrea Urbani, Nicola Montano

Published in: Neurological Sciences | Issue 7/2022

Abstract

Background

Molecular mechanisms underlying trigeminal neuralgia (TN) have been poorly understood. Recently, different biomarkers have been studied in several chronic neuropathic diseases or in neuronal damage, but their role in TN has not yet been investigated. Here, we firstly analyzed the serum levels of the neuron-specific enolase (NSE) (as an index of neuronal tissue damage) in TN patients submitted to surgical treatment. Different cytokines and interleukins related to inflammation were also studied.

Methods

Blood samples from 40 patients were prospectively collected preoperatively and after the surgical procedure, namely microvascular decompression (MVD) and percutaneous balloon compression (PBC). Serum levels of uric acid, NSE, ferritin, CRP, IL-2R, and IL-6 were studied. The acute pain relief (APR) and the pre- and postoperative BNI were used to evaluate the clinical outcome.

Results

Overall, we obtained an APR in 87.5% of patients and a significant reduction of BNI after surgery (p < 0.0001). We observed a significant reduction of postoperative NSE values in the group of patients undergoing MVD (p = 0.0055) and a significant increase of postoperative NSE values in patients undergoing PBC (p < 0.05). Furthermore, in the group of patients undergoing MVD, we found a significant postoperative increase of CRP (p < 0.0001), ferritin (p = 0.001), and IL-6 (p = 0.01) values. The only patient who did not respond to MVD had NSE levels unchanged.

Conclusion

Our results suggest the hypothesis that TN would be related to the neural damage instead of the systemic inflammatory status and indicate NSE as a possible biomarker of response in patients submitted to MVD.

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Title: The role of biomarkers in drug-resistant trigeminal neuralgia: a prospective study in patients submitted to surgical treatment
Authors: Alessandro Rapisarda
Silvia Baroni
Vanessa Gentili
Giacomo Moretti
Benedetta Burattini
Francesca Sarlo
Alessandro Olivi
Andrea Urbani
Nicola Montano
Publication date: 28-02-2022
Publisher: Springer International Publishing
Keywords: Trigeminal Neuralgia
Biomarkers
Published in: Neurological Sciences / Issue 7/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05971-7

At a glance: The STEP trials

Springer Medicine

The role of biomarkers in drug-resistant trigeminal neuralgia: a prospective study in patients submitted to surgical treatment

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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