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Open Access 01-12-2021 | Neurological Tests | COVID-19

Long-term neurological manifestations of COVID-19: prevalence and predictive factors

Authors: Andrea Pilotto, Viviana Cristillo, Stefano Cotti Piccinelli, Nicola Zoppi, Giulio Bonzi, Davide Sattin, Silvia Schiavolin, Alberto Raggi, Antonio Canale, Stefano Gipponi, Ilenia Libri, Martina Frigerio, Michela Bezzi, Matilde Leonardi, Alessandro Padovani

Published in: Neurological Sciences | Issue 12/2021

Abstract

Background

Clinical investigations have argued for long-term neurological manifestations in both hospitalised and non-hospitalised COVID-19 patients. It is unclear whether long-term neurological symptoms and features depend on COVID-19 severity.

Methods

From a sample of 208 consecutive non-neurological patients hospitalised for COVID-19 disease, 165 survivors were re-assessed at 6 months according to a structured standardised clinical protocol. Prevalence and predictors of long-term neurological manifestations were evaluated using multivariate logistic regression analyses.

Results

At 6-month follow-up after hospitalisation due to COVID-19 disease, patients displayed a wide array of symptoms; fatigue (34%), memory/attention (31%) and sleep disorders (30%) were the most frequent. At neurological examination, 40% of patients exhibited neurological abnormalities, such as hyposmia (18.0%), cognitive deficits (17.5%), postural tremor (13.8%) and subtle motor/sensory deficits (7.6%). Older age, premorbid comorbidities and severity of COVID-19 were independent predictors of neurological manifestations in logistic regression analyses.

Conclusions

Premorbid vulnerability and severity of SARS-CoV-2 infection impact on prevalence and severity of long-term neurological manifestations.

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Title: Long-term neurological manifestations of COVID-19: prevalence and predictive factors
Authors: Andrea Pilotto
Viviana Cristillo
Stefano Cotti Piccinelli
Nicola Zoppi
Giulio Bonzi
Davide Sattin
Silvia Schiavolin
Alberto Raggi
Antonio Canale
Stefano Gipponi
Ilenia Libri
Martina Frigerio
Michela Bezzi
Matilde Leonardi
Alessandro Padovani
Publication date: 01-12-2021
Publisher: Springer International Publishing
Keywords: Neurological Tests
Affective Disorder
SARS-CoV-2
Affective Disorder
COVID-19
Fatigue
Published in: Neurological Sciences / Issue 12/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05586-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Long-term neurological manifestations of COVID-19: prevalence and predictive factors

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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