Acute psychotic onset in LGI1-related limbic encephalitis

Excerpt

Leucine-rich glioma-inactivated 1 (LGI1)–related limbic encephalitis is a rare autoimmune disorder associated with antibodies to voltage-gated potassium channel complex that is infrequently accompanied by tumors and with a good response to therapy [1]. The onset and core symptoms are seizures and cognitive disorders. Seizures include generalized tonic-clonic seizures, partial seizures, and dystonia-like episodes involving face and limbs on the same side (FBDS). Among cognitive disorders, short-term memory impairment is the most common. We here describe a patient with LGI1-related encephalitis presenting with isolated acute psychosis. Additionally, we performed a PubMed search to identify papers reporting patients with LGI1-related encephalitis and psychiatric manifestations from January 2010 (the year of description of LGI1-related encephalitis) to May 2020 by using the following terms: LGI1 antibody, limbic encephalitis LGI1, combined with acute psychosis, psychiatric symptoms, and acute behavior disturbances. The search was restricted to full-text papers in English. …