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Neurological Sciences

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01-09-2020 | Coronavirus | COVID-19

Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study

Authors: Jong-moon Hwang, Ju-Hyun Kim, Jin-Sung Park, Min Cheol Chang, Donghwi Park

Published in: Neurological Sciences | Issue 9/2020

Abstract

Introduction

In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death.

Methods

In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients.

Results

In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer’s dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age.

Conclusions

Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD.

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Title: Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study
Authors: Jong-moon Hwang
Ju-Hyun Kim
Jin-Sung Park
Min Cheol Chang
Donghwi Park
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keywords: Coronavirus
Dementia
COVID-19
Dementia
Published in: Neurological Sciences / Issue 9/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04541-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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