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01-12-2020 | Cerebral Small Vessel Disease | Original Article

Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease

Authors: Huimin Chen, Meimei Zhang, Gengliang Liu, Xuemei Wang, Zhan Wang, Huizi Ma, Yuesong Pan, David Wang, Yilong Wang, Tao Feng

Published in: Neurological Sciences | Issue 12/2020

Abstract

Introduction

The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson’s disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD.

Methods

This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models.

Results

Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (β = 0.521, P = 0.011, 95% CI 0.118–0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (β = 0.448, P = 0.047, 95% CI 0.006–0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (β = 0.492, P = 0.041, 95% CI 0.021–0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (P = 0.012, Spearman r = 0.161).

Conclusions

CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD.

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Title: Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease
Authors: Huimin Chen
Meimei Zhang
Gengliang Liu
Xuemei Wang
Zhan Wang
Huizi Ma
Yuesong Pan
David Wang
Yilong Wang
Tao Feng
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Cerebral Small Vessel Disease
Parkinson's Disease
Levodopa
Published in: Neurological Sciences / Issue 12/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04452-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson’s disease

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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