Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Neurological Sciences
Published in: Neurological Sciences 6/2020

01-06-2020 | Hypotension | Review Article

Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis

Authors: Feifei Mu, Qian Jiao, Xixun Du, Hong Jiang

Published in: Neurological Sciences | Issue 6/2020

Login to get access

Abstract

Objective

Orthostatic hypotension (OH) is a common non-motor sign of Parkinson’s disease (PD). Several epidemiological studies have estimated the association between OH and PD with controversial results. Here, a meta-analysis was conducted to evaluate the association between them.

Methods

PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), VIP (Database of Chinese Scientific and Technical Periodicals), and Wanfang databases were searched for eligible publications from October 2003 to December 2017. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Random effect model was used to calculate the pooled odds ratio (OR) with 95% confidence intervals (CIs) from individual studies. Publication bias was estimated by Egger’s test, Begg’s test, and the funnel plot.

Results

Nineteen studies involving 1620 PD patients and 898 healthy controls were included in this meta-analysis. The pooled estimate of the prevalence of OH in PD was 27.7% compared with 7.9% of that in control. The pooled OR of OH with PD was 4.343 (95% CI 3.323–5.676) with a low heterogeneity (I2 = 12.5%, Pheterogeneity = 0.301).

Conclusion

In the present meta-analysis, the pooled OR of OH with PD was 4.343 (95% CI 3.323–5.676) with a low heterogeneity, which showed a significant association between OH and increased risk of PD.
Literature
1.
Jiang H, Song N, Jiao Q, Shi L, Du X (2019) Iron pathophysiology in Parkinson diseases. Adv Exp Med Biol 1173:45–66CrossRef
2.
Elkouzi A, Vedam-Mai V, Eisinger RS, Okun MS (2019) Emerging therapies in Parkinson disease - repurposed drugs and new approaches. Nat Rev Neurol 15:204–223CrossRef
3.
Buob A, Winter H, Kindermann M, Becker G, Moller JC, Oertel WH et al (2010) Parasympathetic but not sympathetic cardiac dysfunction at early stages of Parkinson’s disease. Clin Res Cardiol 99:701–706CrossRef
4.
Wang W, Song N, Jia F, Tang T, Bao W, Zuo C et al (2018) Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson’s disease mouse model. Neurochem Int 114:71–79CrossRef
5.
Chaudhuri KR, Healy DG, Schapira AH (2006) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5:235–245CrossRef
6.
(1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Neurology 46: 1470
7.
Shaw BH, Claydon VE (2014) The relationship between orthostatic hypotension and falling in older adults. Clin Auton Res 24:3–13CrossRef
8.
Cersosimo MG, Benarroch EE (2012) Autonomic involvement in Parkinson’s disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers. J Neurol Sci 313:57–63CrossRef
9.
Papapetropoulos S, Paschalis C, Athanassiadou A, Papadimitriou A, Ellul J, Polymeropoulos MH et al (2001) Clinical phenotype in patients with alpha-synuclein Parkinson’s disease living in Greece in comparison with patients with sporadic Parkinson’s disease. J Neurol Neurosurg Psychiatry 70:662–665CrossRef
10.
Goldstein DS, Holmes C, Bentho O, Sato T, Moak J, Sharabi Y et al (2008) Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy. Parkinsonism Relat Disord 14:600–607CrossRef
11.
Velseboer DC, de Haan RJ, Wieling W, Goldstein DS, de Bie RM (2011) Prevalence of orthostatic hypotension in Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord 17:724–729CrossRef
12.
Song F, Gilbody S (1998) Bias in meta-analysis detected by a simple, graphical test. Increase in studies of publication bias coincided with increasing use of meta-analysis. Bmj 316:471PubMedPubMedCentral
13.
Bonuccelli U, Lucetti C, Del Dotto P, Ceravolo R, Gambaccini G, Bernardini S et al (2003) Orthostatic hypotension in de novo Parkinson disease. Arch Neurol 60:1400–1404CrossRef
14.
Matsui H, Nishinaka K, Oda M, Komatsu K, Kubori T, Udaka F (2006) Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease correlate with major autonomic symptoms? Parkinsonism Relat Disord 12:284–288CrossRef
15.
Nataraj A, Rajput AH (2005) Parkinson’s disease, stroke, and related epidemiology. Mov Disord 20:1476–1480CrossRef
16.
Idiaquez J, Benarroch EE, Rosales H, Milla P, Rios L (2007) Autonomic and cognitive dysfunction in Parkinson’s disease. Clin Auton Res 17:93–98CrossRef
17.
Adhiyaman V, Hobson P, Meara RJ (2008) Central and peripheral autonomic integrity in Parkinson’s disease. Age Ageing 37:578–581CrossRef
18.
Schmidt C, Herting B, Prieur S, Junghanns S, Schweitzer K, Globas C et al (2009) Valsalva manoeuvre in patients with different Parkinsonian disorders. J Neural Transm (Vienna) 116:875–880CrossRef
19.
Wang W, Zhang QH, Zhao HQ (2012) Variability of blood pressure and heart rate in patients with Parkinson’s disease in Thulesius test. Chin J Hemorh:582–585
20.
Hu X, Li ZH, Liu WG, Yan FL (2013) Related risk factors of orthostatic hypotension and postprandial hypotension of Parkinson disease. J Clin Neurol:260–263
21.
Asahina M, Low DA, Mathias CJ, Fujinuma Y, Katagiri A, Yamanaka Y, Shimada J, Poudel A, Kuwabara S (2013) Skin temperature of the hand in multiple system atrophy and Parkinson’s disease. Parkinsonism Relat Disord 19:560–562CrossRef
22.
Nakamura T, Hirayama M, Hara T, Mizutani Y, Suzuki J, Watanabe H, Sobue G (2014) Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson’s disease. Parkinsonism Relat Disord 20:409–414CrossRef
23.
Baschieri F, Calandra-Buonaura G, Doria A, Mastrolilli F, Palareti A, Barletta G, Solieri L, Guaraldi P, Martinelli P, Cortelli P (2015) Cardiovascular autonomic testing performed with a new integrated instrumental approach is useful in differentiating MSA-P from PD at an early stage. Parkinsonism Relat Disord 21:477–482CrossRef
24.
Sprenger FS, Seppi K, Djamshidian A, Reiter E, Nocker M, Mair K, Göbel G, Poewe W (2015) Nonmotor symptoms in subjects without evidence of dopaminergic deficits. Mov Disord 30:976–981CrossRef
25.
Wang Q (2015) The studies of autonomic dysfunctions in Parkinson’s patients
26.
Kim JS, Lee SH, Oh YS, Park JW, An JY, Park SK, Han SR, Lee KS (2016) Cardiovascular autonomic dysfunction in mild and advanced Parkinson’s disease. J Mov Disord 9:97–103CrossRef
27.
Kang SJ, Ahn JY, Kim JS, Cho JW, Kim JY, Choi YY, Kim HT (2016) 24-hour ambulatory blood pressure monitoring in SWEDDs patients with parkinsonism. Can J Neurol Sci 43:390–397CrossRef
28.
Hatsuta H, Takao M, Nakano Y, Nogami A, Uchino A, Sumikura H et al (2016) Reduction of small fibers of thoracic ventral roots and neurons of Intermediolateral nucleus in Parkinson disease and dementia with Lewy bodies. J Park Dis 6:325–334
29.
Campolo J, De Maria R, Cozzi L, Parolini M, Bernardi S, Proserpio P et al (2016) Antioxidant and inflammatory biomarkers for the identification of prodromal Parkinson’s disease. J Neurol Sci 370:167–172CrossRef
30.
Yalcin A, Atmis V, Cengiz OK, Cinar E, Aras S, Varli M, Atli T (2016) Evaluation of cardiac autonomic functions in older Parkinson’s disease patients: a cross-sectional study. Aging Dis 7:28–35CrossRef
31.
Zhao R, Tian T, Ji YF, Hu WT, Liu X, Yang Q et al (2017) Clinical analysis of the prevalence of orthostatic hypotension and related risk factors in 189 patients with Parkinson’s disease. J Apoplexy Nervous Disease:242–246
32.
Jiang H, Wang J, Rogers J, Xie J (2017) Brain Iron metabolism dysfunction in Parkinson’s disease. Mol Neurobiol 54:3078–3101CrossRef
33.
Sulzer D, Edwards RH (2019) The physiological role of alpha-synuclein and its relationship to Parkinson’s disease. J Neurochem 150:475–486CrossRef
34.
Zhang Z, Shi L, Du X, Jiao Q, Jiang H (2017) Acute action of rotenone on excitability of catecholaminergic neurons in rostral ventrolateral medulla. Brain Res Bull 134:151–161CrossRef
35.
Wang Y, Chen AQ, Xue Y, Liu MF, Liu C, Liu YH, Pan YP, Diao HL, Chen L (2019) Orexins alleviate motor deficits via increasing firing activity of pallidal neurons in a mouse model of Parkinson’s disease. Am J Physiol Cell Physiol 317:C800–C812CrossRef
36.
Sharabi Y, Goldstein DS (2011) Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J Neurol Sci 310:123–128CrossRef
37.
Handa SP, Wong J, Wolf HK (1995) The relationship of plasma norepinephrine levels and aortic distensibility in elderly with isolated systolic hypertension. Am J Hypertens 8:422–425CrossRef
38.
Wullner U, Schmitz-Hubsch T, Antony G, Fimmers R, Spottke A, Oertel WH et al (2007) Autonomic dysfunction in 3414 Parkinson’s disease patients enrolled in the German Network on Parkinson’s disease (KNP e.V.): the effect of ageing. Eur J Neurol 14:1405–1408CrossRef
39.
Perez-Lloret S, Rey MV, Fabre N, Ory F, Spampinato U, Senard JM, Pavy-le Traon A, Montastruc JL, Rascol O (2012) Factors related to orthostatic hypotension in Parkinson’s disease. Parkinsonism Relat Disord 18:501–505CrossRef
40.
Perlmuter LC, Sarda G, Casavant V, Mosnaim AD (2013) A review of the etiology, associated comorbidities, and treatment of orthostatic hypotension. Am J Ther 20:279–291CrossRef
41.
Jamnadas-Khoda J, Koshy S, Mathias CJ, Muthane UB, Ragothaman M, Dodaballapur SK (2009) Are current recommendations to diagnose orthostatic hypotension in Parkinson’s disease satisfactory? Mov Disord 24:1747–1751CrossRef
42.
Ziemssen T, Reichmann H (2010) Cardiovascular autonomic dysfunction in Parkinson’s disease. J Neurol Sci 289:74–80CrossRef
43.
Fereshtehnejad SM, Lokk J (2014) Orthostatic hypotension in patients with Parkinson’s disease and atypical parkinsonism. Parkinsons Dis 2014:475854PubMedPubMedCentral
Metadata
Title
Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis
Authors
Feifei Mu
Qian Jiao
Xixun Du
Hong Jiang
Publication date
01-06-2020
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 6/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04277-w

Other articles of this Issue 6/2020

Neurological Sciences 6/2020 Go to the issue

COVID-19

Letter to editor: brain awareness week, CoVID-19 infection and neurological sciences

Letter to the Editor

Pure allocentric unilateral spatial neglect in a case of Alzheimer’s disease presenting with posterior cortical atrophy syndrome

Original Article

The role of the neuropsychologist in memory clinics

COVID-19

Assessing disability and relapses in multiple sclerosis on tele-neurology

Original Article

Multiple sclerosis and neuromyelitis optica spectrum disorders in Argentina: comparing baseline data from the Argentinean MS Registry (RelevarEM)

Review Article

The efficacy of statins in the treatment of Alzheimer’s disease: a meta-analysis of randomized controlled trial