Skip to main content
Top
Published in: Neurological Sciences 9/2019

01-09-2019 | Neuroblastoma | Quiz Cases

Ganglioneuroblastoma in children

Authors: Ioana Badiu Tișa, Gabriel Samașca, Cornel Aldea, Iulia Lupan, Dorin Farcau, Peter Makovicky

Published in: Neurological Sciences | Issue 9/2019

Login to get access

Abstract

Introduction

Neuroblastoma ranks third among pediatric malignancies.

Case report

The case of a 3-year-old child is presented, who suddenly had frequent, unproductive, emetic cough; fever; and weight loss. Lung X-ray showed an opacity situated in the posterior superior mediastinum. Thoracic ultrasound revealed a slightly inhomogeneous, hypoechoic mass located in the posterior superior mediastinum. Computed tomography evidenced a tumor mass with homogeneous appearance in the costo-vertebral groove. Histological examination confirmed the diagnosis of ganglioneuroblastoma.

Conclusion

Although history and clinical examination provided few elements, diagnosis was made based on imaging and histopathological examination.
Literature
1.
go back to reference Ater JL (2015) Neuroblastoma. In: Nelson Textbook of Pediatrics 20th. Elsevier, Philadelphia, pp 1709–1711 Ater JL (2015) Neuroblastoma. In: Nelson Textbook of Pediatrics 20th. Elsevier, Philadelphia, pp 1709–1711
2.
go back to reference Cabana M, Lars M, Wagner MD (2018) Neuroblastoma. In: the 5-minute pediatric consult. 8-th edition. Wolters Kluwer Health, Philadelphia, pp 639–641 Cabana M, Lars M, Wagner MD (2018) Neuroblastoma. In: the 5-minute pediatric consult. 8-th edition. Wolters Kluwer Health, Philadelphia, pp 639–641
3.
go back to reference Henderson TO, Bhatia S, Pinto N et al (2011) Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children’s Oncology Group study. J Clin Oncol 29:76–82CrossRefPubMed Henderson TO, Bhatia S, Pinto N et al (2011) Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children’s Oncology Group study. J Clin Oncol 29:76–82CrossRefPubMed
4.
go back to reference Shimada H, Ambros IM, Dehner LP, Hata JI, Joshi VV, Roald B, Stram DO, Gerbing RB, Lukens JN, Matthay KK, Castleberry RP (1999) The International Neuroblastoma Pathology Classification (the Shimada system). Cancer 86:364–372CrossRefPubMed Shimada H, Ambros IM, Dehner LP, Hata JI, Joshi VV, Roald B, Stram DO, Gerbing RB, Lukens JN, Matthay KK, Castleberry RP (1999) The International Neuroblastoma Pathology Classification (the Shimada system). Cancer 86:364–372CrossRefPubMed
5.
go back to reference Morgenstern DA, London WB, Stephens D, Volchenboum SL, Hero B, di Cataldo A, Nakagawara A, Shimada H, Ambros PF, Matthay KK, Cohn SL, Pearson ADJ, Irwin MS (2014) Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: a study from the International Neuroblastoma Risk Group Database. J Clin Oncol 32:1228–1235CrossRefPubMedPubMedCentral Morgenstern DA, London WB, Stephens D, Volchenboum SL, Hero B, di Cataldo A, Nakagawara A, Shimada H, Ambros PF, Matthay KK, Cohn SL, Pearson ADJ, Irwin MS (2014) Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: a study from the International Neuroblastoma Risk Group Database. J Clin Oncol 32:1228–1235CrossRefPubMedPubMedCentral
6.
go back to reference Brisse HJ, McCarville MB, Granata C et al (2011) Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology 261:243–257CrossRefPubMed Brisse HJ, McCarville MB, Granata C et al (2011) Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology 261:243–257CrossRefPubMed
7.
go back to reference Hel W-G, Yan Y, Tang W et al (2017) Clinical and biological features of neuroblastic tumors: a comparison of neuroblastoma and ganglioneuroblastoma. Oncotarget 23:37730–33739 Hel W-G, Yan Y, Tang W et al (2017) Clinical and biological features of neuroblastic tumors: a comparison of neuroblastoma and ganglioneuroblastoma. Oncotarget 23:37730–33739
8.
go back to reference Vo KT, Matthay KK, Neuhaus J, London WB, Hero B, Ambros PF, Nakagawara A, Miniati D, Wheeler K, Pearson ADJ, Cohn SL, DuBois SG (2014) Clinical, biologic and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project. J Clin Oncol 32:3169–3176CrossRefPubMedPubMedCentral Vo KT, Matthay KK, Neuhaus J, London WB, Hero B, Ambros PF, Nakagawara A, Miniati D, Wheeler K, Pearson ADJ, Cohn SL, DuBois SG (2014) Clinical, biologic and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project. J Clin Oncol 32:3169–3176CrossRefPubMedPubMedCentral
10.
go back to reference Jamer T, Pytrus T, Zaleska-Dorobisz U et al (2018) Ganglioneuroblastoma in a child with chronic abdominal pain - a case report. Dev Period Med 22:364–370PubMed Jamer T, Pytrus T, Zaleska-Dorobisz U et al (2018) Ganglioneuroblastoma in a child with chronic abdominal pain - a case report. Dev Period Med 22:364–370PubMed
11.
go back to reference Manjaly JG, Alexander VR, Pepper CM et al (2015) Primary cervical ganglioneuroblastoma. Int J Pediatr Otorhinolaryngol 79:1007–1012CrossRefPubMed Manjaly JG, Alexander VR, Pepper CM et al (2015) Primary cervical ganglioneuroblastoma. Int J Pediatr Otorhinolaryngol 79:1007–1012CrossRefPubMed
12.
go back to reference Steenberge SP, Prayson RA (2014) Pediatric cerebral ganglioneuroblastoma. J Clin Neurosci 21:2023–2025CrossRefPubMed Steenberge SP, Prayson RA (2014) Pediatric cerebral ganglioneuroblastoma. J Clin Neurosci 21:2023–2025CrossRefPubMed
13.
go back to reference Nabavizadeh SA, Feygin T, Harding BN, Bilaniuk LT, Zimmerman RA, Vossough A (2014) Imaging findings of patients with metastatic neuroblastoma to the brain. Acad Radiol 21:329–337CrossRefPubMed Nabavizadeh SA, Feygin T, Harding BN, Bilaniuk LT, Zimmerman RA, Vossough A (2014) Imaging findings of patients with metastatic neuroblastoma to the brain. Acad Radiol 21:329–337CrossRefPubMed
14.
15.
16.
go back to reference Federico SM, Brady SL, Pappo A, Wu J, Mao S, McPherson VJ, Young A, Furman WL, Kaufman R, Kaste S (2015) The role of chest computed tomography (CT) as a surveillance tool in children with high-risk neuroblastoma. Pediatr Blood Cancer 62:976–981CrossRefPubMedPubMedCentral Federico SM, Brady SL, Pappo A, Wu J, Mao S, McPherson VJ, Young A, Furman WL, Kaufman R, Kaste S (2015) The role of chest computed tomography (CT) as a surveillance tool in children with high-risk neuroblastoma. Pediatr Blood Cancer 62:976–981CrossRefPubMedPubMedCentral
17.
go back to reference Takeda Y, Sano H, Kawano A, Mochizuki K, Takahashi N, Kobayashi S, Ohara Y, Tasaki K, Hosoya M, Kikuta A (2018) Usefulness of fluorodeoxyglucose positron emission tomography / computed tomography for detection of a neuroblastic nodule in a ganglioneuroblastoma: a case report. J Med Case Rep 12:119CrossRefPubMedPubMedCentral Takeda Y, Sano H, Kawano A, Mochizuki K, Takahashi N, Kobayashi S, Ohara Y, Tasaki K, Hosoya M, Kikuta A (2018) Usefulness of fluorodeoxyglucose positron emission tomography / computed tomography for detection of a neuroblastic nodule in a ganglioneuroblastoma: a case report. J Med Case Rep 12:119CrossRefPubMedPubMedCentral
18.
go back to reference Defferrari R, Mazzocco K, Ambros IM, Ambros PF, Bedwell C, Beiske K, Bénard J, Berbegall AP, Bown N, Combaret V, Couturier J, Erminio G, Gambini C, Garaventa A, Gross N, Haupt R, Kohler J, Jeison M, Lunec J, Marques B, Martinsson T, Noguera R, Parodi S, Schleiermacher G, Tweddle DA, Valent A, van Roy N, Vicha A, Villamon E, Tonini GP (2015) Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification. Br J Cancer 112:290–295CrossRefPubMed Defferrari R, Mazzocco K, Ambros IM, Ambros PF, Bedwell C, Beiske K, Bénard J, Berbegall AP, Bown N, Combaret V, Couturier J, Erminio G, Gambini C, Garaventa A, Gross N, Haupt R, Kohler J, Jeison M, Lunec J, Marques B, Martinsson T, Noguera R, Parodi S, Schleiermacher G, Tweddle DA, Valent A, van Roy N, Vicha A, Villamon E, Tonini GP (2015) Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification. Br J Cancer 112:290–295CrossRefPubMed
19.
go back to reference Schleiermacher G, Michon J, Ribeiro A, Pierron G, Mosseri V, Rubie H, Munzer C, Bénard J, Auger N, Combaret V, Janoueix-Lerosey I, Pearson A, Tweddle DA, Bown N, Gerrard M, Wheeler K, Noguera R, Villamon E, Cañete A, Castel V, Marques B, de Lacerda A, Tonini GP, Mazzocco K, Defferrari R, de Bernardi B, di Cataldo A, van Roy N, Brichard B, Ladenstein R, Ambros I, Ambros P, Beiske K, Delattre O, Couturier J (2011) Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma. Br J Cancer 105:1940–1948CrossRefPubMedPubMedCentral Schleiermacher G, Michon J, Ribeiro A, Pierron G, Mosseri V, Rubie H, Munzer C, Bénard J, Auger N, Combaret V, Janoueix-Lerosey I, Pearson A, Tweddle DA, Bown N, Gerrard M, Wheeler K, Noguera R, Villamon E, Cañete A, Castel V, Marques B, de Lacerda A, Tonini GP, Mazzocco K, Defferrari R, de Bernardi B, di Cataldo A, van Roy N, Brichard B, Ladenstein R, Ambros I, Ambros P, Beiske K, Delattre O, Couturier J (2011) Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma. Br J Cancer 105:1940–1948CrossRefPubMedPubMedCentral
20.
go back to reference Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H (2009) Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer 53:563–569CrossRefPubMedPubMedCentral Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H (2009) Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer 53:563–569CrossRefPubMedPubMedCentral
21.
go back to reference Strother DR, London WB, Schmidt ML, Brodeur GM, Shimada H, Thorner P, Collins MH, Tagge E, Adkins S, Reynolds CP, Murray K, Lavey RS, Matthay KK, Castleberry R, Maris JM, Cohn SL (2012) Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children’s Oncology Group study P9641. J Clin Oncol 30:1842–1848CrossRefPubMedPubMedCentral Strother DR, London WB, Schmidt ML, Brodeur GM, Shimada H, Thorner P, Collins MH, Tagge E, Adkins S, Reynolds CP, Murray K, Lavey RS, Matthay KK, Castleberry R, Maris JM, Cohn SL (2012) Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children’s Oncology Group study P9641. J Clin Oncol 30:1842–1848CrossRefPubMedPubMedCentral
22.
go back to reference Nuchtern JG, London WB, Barnewolt CE, Naranjo A, McGrady PW, Geiger JD, Diller L, Schmidt ML, Maris JM, Cohn SL, Shamberger RC (2012) A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children’s Oncology Group study. Ann Surg 256:573–580CrossRefPubMedPubMedCentral Nuchtern JG, London WB, Barnewolt CE, Naranjo A, McGrady PW, Geiger JD, Diller L, Schmidt ML, Maris JM, Cohn SL, Shamberger RC (2012) A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children’s Oncology Group study. Ann Surg 256:573–580CrossRefPubMedPubMedCentral
23.
go back to reference Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B (2016) Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. BMC Cancer 16:542CrossRefPubMedPubMedCentral Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B (2016) Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. BMC Cancer 16:542CrossRefPubMedPubMedCentral
24.
go back to reference Yang T, Huang Y, Xu T, Tan T, Yang J, Pan J, Hu C, Li J, Zou Y (2017) Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. Pediatr Surg Int 33:955–959CrossRefPubMed Yang T, Huang Y, Xu T, Tan T, Yang J, Pan J, Hu C, Li J, Zou Y (2017) Surgical management and outcomes of ganglioneuroma and ganglioneuroblastoma-intermixed. Pediatr Surg Int 33:955–959CrossRefPubMed
Metadata
Title
Ganglioneuroblastoma in children
Authors
Ioana Badiu Tișa
Gabriel Samașca
Cornel Aldea
Iulia Lupan
Dorin Farcau
Peter Makovicky
Publication date
01-09-2019
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 9/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-019-03932-1

Other articles of this Issue 9/2019

Neurological Sciences 9/2019 Go to the issue