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01-08-2019 | Bullous Pemphigoid | Original Article

Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

Authors: Jack Cheng, Hsin-Ping Liu, Su-Lun Hwang, Lee-Fen Hsu, Wei-Yong Lin, Fuu-Jen Tsai

Published in: Neurological Sciences | Issue 8/2019

Abstract

Dementia is one of the diabetic complications under intensive study. Alteration of synaptic adhesion protein (SAP) associates with neurological diseases, including Alzheimer’s disease. However, the regulation of SAPs in the brain of diabetes mellitus remains elusive. To pinpoint the candidate SAPs underlining the mechanism of diabetic dementia, we investigated expression profiling of SAPs in both streptozotocin (STZ)-induced diabetic mice, App^{NL-G-F/NL-G-F} mice, and amyloid precursor protein intracellular domain (AICD)-induced human neural cell line from public databases. DST (Dystonin/BPAG1) was identified upregulated in both models. Our finding suggests that DST alteration may involve in the mechanism of diabetic dementia.

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Title: Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis
Authors: Jack Cheng
Hsin-Ping Liu
Su-Lun Hwang
Lee-Fen Hsu
Wei-Yong Lin
Fuu-Jen Tsai
Publication date: 01-08-2019
Publisher: Springer International Publishing
Keywords: Bullous Pemphigoid
Alzheimer's Disease
Dementia
Alzheimer's Disease
Dementia
Published in: Neurological Sciences / Issue 8/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03879-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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