Replication study of GWAS risk loci in Greek multiple sclerosis patients

go back to reference Compston A, Coles A (2008) Multiple sclerosis. Lancet (London, England) 372(9648):1502–1517. https://doi.org/10.1016/s0140-6736(08)61620-7 CrossRef Compston A, Coles A (2008) Multiple sclerosis. Lancet (London, England) 372(9648):1502–1517. https://​doi.​org/​10.​1016/​s0140-6736(08)61620-7 CrossRef

go back to reference Compston A, Sadovnick AD (1992) Epidemiology and genetics of multiple sclerosis. Curr Opin Neurol Neurosurg 5(2):175–181PubMed Compston A, Sadovnick AD (1992) Epidemiology and genetics of multiple sclerosis. Curr Opin Neurol Neurosurg 5(2):175–181PubMed

go back to reference Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 (2009) Nat Genet 41(7):824–828. https://doi.org/10.1038/ng.396 CrossRef Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 (2009) Nat Genet 41(7):824–828. https://​doi.​org/​10.​1038/​ng.​396 CrossRef

go back to reference Sokratous M, Dardiotis E, Bellou E, Tsouris Z, Michalopoulou A, Dardioti M, Siokas V, Rikos D, Tsatsakis A, Kovatsi L, Bogdanos DP, Hadjigeorgiou GM (2018) CpG Island methylation patterns in relapsing-remitting multiple sclerosis. J Mol Neurosci: MN 64(3):478–484. https://doi.org/10.1007/s12031-018-1046-x CrossRefPubMed Sokratous M, Dardiotis E, Bellou E, Tsouris Z, Michalopoulou A, Dardioti M, Siokas V, Rikos D, Tsatsakis A, Kovatsi L, Bogdanos DP, Hadjigeorgiou GM (2018) CpG Island methylation patterns in relapsing-remitting multiple sclerosis. J Mol Neurosci: MN 64(3):478–484. https://​doi.​org/​10.​1007/​s12031-018-1046-x CrossRefPubMed

go back to reference Sokratous M, Dardiotis E, Tsouris Z, Bellou E, Michalopoulou A, Siokas V, Arseniou S, Stamati T, Tsivgoulis G, Bogdanos D, Hadjigeorgiou GM (2016) Deciphering the role of DNA methylation in multiple sclerosis: emerging issues. Auto- immunity highlights 7(1):12. https://doi.org/10.1007/s13317-016-0084-z CrossRefPubMedPubMedCentral Sokratous M, Dardiotis E, Tsouris Z, Bellou E, Michalopoulou A, Siokas V, Arseniou S, Stamati T, Tsivgoulis G, Bogdanos D, Hadjigeorgiou GM (2016) Deciphering the role of DNA methylation in multiple sclerosis: emerging issues. Auto- immunity highlights 7(1):12. https://​doi.​org/​10.​1007/​s13317-016-0084-z CrossRefPubMedPubMedCentral

go back to reference Bomprezzi R, Kovanen PE, Martin R (2003) New approaches to investigating heterogeneity in complex traits. J Med Genet 40(8):553–559CrossRef Bomprezzi R, Kovanen PE, Martin R (2003) New approaches to investigating heterogeneity in complex traits. J Med Genet 40(8):553–559CrossRef

go back to reference Mentis AA, Dardiotis E, Grigoriadis N, Petinaki E, Hadjigeorgiou GM (2017) Viruses and multiple sclerosis: from mechanisms and pathways to translational research opportunities. Mol Neurobiol 54(5):3911–3923. https://doi.org/10.1007/s12035-017-0530-6 CrossRefPubMed Mentis AA, Dardiotis E, Grigoriadis N, Petinaki E, Hadjigeorgiou GM (2017) Viruses and multiple sclerosis: from mechanisms and pathways to translational research opportunities. Mol Neurobiol 54(5):3911–3923. https://​doi.​org/​10.​1007/​s12035-017-0530-6 CrossRefPubMed

go back to reference Trapp BD, Vignos M, Dudman J, Chang A, Fisher E, Staugaitis SM, Battapady H, Mork S, Ontaneda D, Jones SE, Fox RJ, Chen J, Nakamura K, Rudick RA (2018) Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study. Lancet Neurol. https://doi.org/10.1016/S1474-4422(18)30245-X Trapp BD, Vignos M, Dudman J, Chang A, Fisher E, Staugaitis SM, Battapady H, Mork S, Ontaneda D, Jones SE, Fox RJ, Chen J, Nakamura K, Rudick RA (2018) Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study. Lancet Neurol. https://​doi.​org/​10.​1016/​S1474-4422(18)30245-X

go back to reference Zarei M, Chandran S, Compston A, Hodges J (2003) Cognitive presentation of multiple sclerosis: evidence for a cortical variant. J Neurol Neurosurg Psychiatry 74(7):872–877CrossRef Zarei M, Chandran S, Compston A, Hodges J (2003) Cognitive presentation of multiple sclerosis: evidence for a cortical variant. J Neurol Neurosurg Psychiatry 74(7):872–877CrossRef

go back to reference Bashinskaya VV, Kulakova OG, Boyko AN, Favorov AV, Favorova OO (2015) A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. Hum Genet 134(11–12):1143–1162. https://doi.org/10.1007/s00439-015-1601-2 CrossRefPubMed Bashinskaya VV, Kulakova OG, Boyko AN, Favorov AV, Favorova OO (2015) A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. Hum Genet 134(11–12):1143–1162. https://​doi.​org/​10.​1007/​s00439-015-1601-2 CrossRefPubMed

go back to reference Kowalec K, Wright GEB, Drogemoller BI, Aminkeng F, Bhavsar AP, Kingwell E, Yoshida EM, Traboulsee A, Marrie RA, Kremenchutzky M, Campbell TL, Duquette P, Chalasani N, Wadelius M, Hallberg P, Xia Z, De Jager PL, Denny JC, Davis MF, Ross CJD, Tremlett H, Carleton BC (2018) Common variation near IRF6 is associated with IFN-beta-induced liver injury in multiple sclerosis. Nat Genet 50(8):1081–1085. https://doi.org/10.1038/s41588-018-0168-y CrossRefPubMed Kowalec K, Wright GEB, Drogemoller BI, Aminkeng F, Bhavsar AP, Kingwell E, Yoshida EM, Traboulsee A, Marrie RA, Kremenchutzky M, Campbell TL, Duquette P, Chalasani N, Wadelius M, Hallberg P, Xia Z, De Jager PL, Denny JC, Davis MF, Ross CJD, Tremlett H, Carleton BC (2018) Common variation near IRF6 is associated with IFN-beta-induced liver injury in multiple sclerosis. Nat Genet 50(8):1081–1085. https://​doi.​org/​10.​1038/​s41588-018-0168-y CrossRefPubMed

go back to reference Dardiotis E, Panayiotou E, Provatas A, Christodoulou K, Hadjisavvas A, Antoniades A, Lourbopoulos A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T (2017) Gene variants of adhesion molecules act as modifiers of disease severity in MS. Neurology(R) Neuroimmunol Neuroinflammation 4(4):e350. https://doi.org/10.1212/nxi.0000000000000350 CrossRef Dardiotis E, Panayiotou E, Provatas A, Christodoulou K, Hadjisavvas A, Antoniades A, Lourbopoulos A, Pantzaris M, Grigoriadis N, Hadjigeorgiou GM, Kyriakides T (2017) Gene variants of adhesion molecules act as modifiers of disease severity in MS. Neurology(R) Neuroimmunol Neuroinflammation 4(4):e350. https://​doi.​org/​10.​1212/​nxi.​0000000000000350​ CrossRef

go back to reference Sawcer S, Franklin RJ, Ban M (2014) Multiple sclerosis genetics. Lancet Neurol 13(7):700–709. https://doi.org/10.1016/s1474-4422(14)70041-9 CrossRefPubMed Sawcer S, Franklin RJ, Ban M (2014) Multiple sclerosis genetics. Lancet Neurol 13(7):700–709. https://​doi.​org/​10.​1016/​s1474-4422(14)70041-9 CrossRefPubMed

go back to reference Axisa PP, Hafler DA (2016) Multiple sclerosis: genetics, biomarkers, treatments. Curr Opin Neurol 29(3):345–353. https://doi.org/10.1097/wco.0000000000000319 CrossRefPubMed Axisa PP, Hafler DA (2016) Multiple sclerosis: genetics, biomarkers, treatments. Curr Opin Neurol 29(3):345–353. https://​doi.​org/​10.​1097/​wco.​0000000000000319​ CrossRefPubMed

go back to reference Lill CM (2014) Recent advances and future challenges in the genetics of multiple sclerosis. Front Neurol 5:130. https://doi.org/10.3389/fneur.2014.00130 CrossRefPubMedPubMedCentral Lill CM (2014) Recent advances and future challenges in the genetics of multiple sclerosis. Front Neurol 5:130. https://​doi.​org/​10.​3389/​fneur.​2014.​00130 CrossRefPubMedPubMedCentral

go back to reference Torkamani A, Pham P, Libiger O, Bansal V, Zhang G, Scott-Van Zeeland AA, Tewhey R, Topol EJ, Schork NJ (2012) Clinical implications of human population differences in genome-wide rates of functional genotypes. Front Genet 3:211. https://doi.org/10.3389/fgene.2012.00211 CrossRefPubMedPubMedCentral Torkamani A, Pham P, Libiger O, Bansal V, Zhang G, Scott-Van Zeeland AA, Tewhey R, Topol EJ, Schork NJ (2012) Clinical implications of human population differences in genome-wide rates of functional genotypes. Front Genet 3:211. https://​doi.​org/​10.​3389/​fgene.​2012.​00211 CrossRefPubMedPubMedCentral

go back to reference Patsopoulos NA, Bayer Pharma MSGWG, Steering Committees of Studies Evaluating I-b, a CCRA, Consortium AN, GeneMsa, International Multiple Sclerosis Genetics C, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalban J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI (2011) Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 70(6):897–912. https://doi.org/10.1002/ana.22609 CrossRefPubMedPubMedCentral Patsopoulos NA, Bayer Pharma MSGWG, Steering Committees of Studies Evaluating I-b, a CCRA, Consortium AN, GeneMsa, International Multiple Sclerosis Genetics C, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalban J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI (2011) Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 70(6):897–912. https://​doi.​org/​10.​1002/​ana.​22609 CrossRefPubMedPubMedCentral

go back to reference Aggelakis K, Zacharaki F, Dardiotis E, Xiromerisiou G, Tsimourtou V, Ralli S, Gkaraveli M, Bourpoulas D, Rodopoulou P, Papadimitriou A, Hadjigeorgiou G (2010) Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS. Neurol Sci 31(3):253–257. https://doi.org/10.1007/s10072-009-0155-2 CrossRefPubMed Aggelakis K, Zacharaki F, Dardiotis E, Xiromerisiou G, Tsimourtou V, Ralli S, Gkaraveli M, Bourpoulas D, Rodopoulou P, Papadimitriou A, Hadjigeorgiou G (2010) Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS. Neurol Sci 31(3):253–257. https://​doi.​org/​10.​1007/​s10072-009-0155-2 CrossRefPubMed

go back to reference Bauchet M, McEvoy B, Pearson LN, Quillen EE, Sarkisian T, Hovhannesyan K, Deka R, Bradley DG, Shriver MD (2007) Measuring European population stratification with microarray genotype data. Am J Hum Genet 80(5):948–956. https://doi.org/10.1086/513477 CrossRefPubMedPubMedCentral Bauchet M, McEvoy B, Pearson LN, Quillen EE, Sarkisian T, Hovhannesyan K, Deka R, Bradley DG, Shriver MD (2007) Measuring European population stratification with microarray genotype data. Am J Hum Genet 80(5):948–956. https://​doi.​org/​10.​1086/​513477 CrossRefPubMedPubMedCentral

go back to reference Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15(2):97–98. https://doi.org/10.1038/sj.cr.7290272 CrossRefPubMed Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15(2):97–98. https://​doi.​org/​10.​1038/​sj.​cr.​7290272 CrossRefPubMed

go back to reference Spencer CC, Su Z, Donnelly P, Marchini J (2009) Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 5(5):e1000477. https://doi.org/10.1371/journal.pgen.1000477 CrossRefPubMedPubMedCentral Spencer CC, Su Z, Donnelly P, Marchini J (2009) Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 5(5):e1000477. https://​doi.​org/​10.​1371/​journal.​pgen.​1000477 CrossRefPubMedPubMedCentral

go back to reference Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP (2008) Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A 105(17):6457–6462. https://doi.org/10.1073/pnas.0801508105 CrossRefPubMedPubMedCentral Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP (2008) Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A 105(17):6457–6462. https://​doi.​org/​10.​1073/​pnas.​0801508105 CrossRefPubMedPubMedCentral

go back to reference The International Multiple Sclerosis Genetics C (2010) IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun 11(5):397–405. https://doi.org/10.1038/gene.2010.28 CrossRef The International Multiple Sclerosis Genetics C (2010) IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun 11(5):397–405. https://​doi.​org/​10.​1038/​gene.​2010.​28 CrossRef

go back to reference Tran T, Paz P, Velichko S, Cifrese J, Belur P, Yamaguchi KD, Ku K, Mirshahpanah P, Reder AT, Croze E (2010) Interferonbeta-1b induces the expression of RGS1 a negative regulator of G-protein signaling. Int J Cell Biol 2010:529376. https://doi.org/10.1155/2010/529376 CrossRefPubMed Tran T, Paz P, Velichko S, Cifrese J, Belur P, Yamaguchi KD, Ku K, Mirshahpanah P, Reder AT, Croze E (2010) Interferonbeta-1b induces the expression of RGS1 a negative regulator of G-protein signaling. Int J Cell Biol 2010:529376. https://​doi.​org/​10.​1155/​2010/​529376 CrossRefPubMed

go back to reference De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009) Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 41(7):776–782. https://doi.org/10.1038/ng.401 CrossRefPubMedPubMedCentral De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009) Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 41(7):776–782. https://​doi.​org/​10.​1038/​ng.​401 CrossRefPubMedPubMedCentral

go back to reference Jiang T, Li L, Wang Y, Zhao C, Yang J, Ma D, Guan Y, Zhao D, Bao Y, Wang Y, Yang J (2016) The association between genetic polymorphism rs703842 in CYP27B1 and multiple sclerosis: a meta-analysis. Medicine 95(19):e3612. https://doi.org/10.1097/md.0000000000003612 CrossRefPubMedPubMedCentral Jiang T, Li L, Wang Y, Zhao C, Yang J, Ma D, Guan Y, Zhao D, Bao Y, Wang Y, Yang J (2016) The association between genetic polymorphism rs703842 in CYP27B1 and multiple sclerosis: a meta-analysis. Medicine 95(19):e3612. https://​doi.​org/​10.​1097/​md.​0000000000003612​ CrossRefPubMedPubMedCentral

go back to reference Jones G, Prosser DE, Kaufmann M (2014) Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res 55(1):13–31. https://doi.org/10.1194/jlr.R031534 CrossRefPubMedPubMedCentral Jones G, Prosser DE, Kaufmann M (2014) Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res 55(1):13–31. https://​doi.​org/​10.​1194/​jlr.​R031534 CrossRefPubMedPubMedCentral

go back to reference Alharbi FM (2015) Update in vitamin D and multiple sclerosis. Neurosciences 20(4):329–335. https://doi.org/10.17712/nsj.2015.4.20150357 CrossRefPubMedPubMedCentral Alharbi FM (2015) Update in vitamin D and multiple sclerosis. Neurosciences 20(4):329–335. https://​doi.​org/​10.​17712/​nsj.​2015.​4.​20150357 CrossRefPubMedPubMedCentral

go back to reference Ramagopalan SV, Dyment DA, Cader MZ, Morrison KM, Disanto G, Morahan JM, Berlanga-Taylor AJ, Handel A, De Luca GC, Sadovnick AD, Lepage P, Montpetit A, Ebers GC (2011) Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 70(6):881–886. https://doi.org/10.1002/ana.22678 CrossRefPubMed Ramagopalan SV, Dyment DA, Cader MZ, Morrison KM, Disanto G, Morahan JM, Berlanga-Taylor AJ, Handel A, De Luca GC, Sadovnick AD, Lepage P, Montpetit A, Ebers GC (2011) Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 70(6):881–886. https://​doi.​org/​10.​1002/​ana.​22678 CrossRefPubMed

go back to reference Runia TF, Hop WC, de Rijke YB, Buljevac D, Hintzen RQ (2012) Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 79(3):261–266. https://doi.org/10.1212/WNL.0b013e31825fdec7 CrossRefPubMed Runia TF, Hop WC, de Rijke YB, Buljevac D, Hintzen RQ (2012) Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 79(3):261–266. https://​doi.​org/​10.​1212/​WNL.​0b013e31825fdec7​ CrossRefPubMed

go back to reference Berge T, Leikfoss IS, Brorson IS, Bos SD, Page CM, Gustavsen MW, Bjolgerud A, Holmoy T, Celius EG, Damoiseaux J, Smolders J, Harbo HF, Spurkland A (2016) The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells. Genes Immun 17(2):118–127. https://doi.org/10.1038/gene.2015.61 CrossRefPubMedPubMedCentral Berge T, Leikfoss IS, Brorson IS, Bos SD, Page CM, Gustavsen MW, Bjolgerud A, Holmoy T, Celius EG, Damoiseaux J, Smolders J, Harbo HF, Spurkland A (2016) The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells. Genes Immun 17(2):118–127. https://​doi.​org/​10.​1038/​gene.​2015.​61 CrossRefPubMedPubMedCentral

go back to reference Huang SQ, Zhang N, Zhou ZX, Huang CC, Zeng CL, Xiao D, Guo CC, Han YJ, Ye XH, Ye XG, Ou ML, Zhang BH, Liu Y, Zeng EY, Yang G, Jing CX (2017) Association of LPP and TAGAP polymorphisms with celiac disease risk: a meta-analysis. Int J Environ Res Public Health 14(2). https://doi.org/10.3390/ijerph14020171 Huang SQ, Zhang N, Zhou ZX, Huang CC, Zeng CL, Xiao D, Guo CC, Han YJ, Ye XH, Ye XG, Ou ML, Zhang BH, Liu Y, Zeng EY, Yang G, Jing CX (2017) Association of LPP and TAGAP polymorphisms with celiac disease risk: a meta-analysis. Int J Environ Res Public Health 14(2). https://​doi.​org/​10.​3390/​ijerph14020171

go back to reference Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Sondergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelcic I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppa V, Liberatore G, Lie BA, Lill CM, Linden M, Link J, Luessi F, Lycke J, Macciardi F, Mannisto S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL (2013) Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 45(11):1353–1360. https://doi.org/10.1038/ng.2770 CrossRefPubMedPubMedCentral Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Sondergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelcic I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppa V, Liberatore G, Lie BA, Lill CM, Linden M, Link J, Luessi F, Lycke J, Macciardi F, Mannisto S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL (2013) Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 45(11):1353–1360. https://​doi.​org/​10.​1038/​ng.​2770 CrossRefPubMedPubMedCentral

go back to reference Mc Guire C, Prinz M, Beyaert R, van Loo G (2013) Nuclear factor kappa B (NF-kappaB) in multiple sclerosis pathology. Trends Mol Med 19(10):604–613. https://doi.org/10.1016/j.molmed.2013.08.001 CrossRefPubMed Mc Guire C, Prinz M, Beyaert R, van Loo G (2013) Nuclear factor kappa B (NF-kappaB) in multiple sclerosis pathology. Trends Mol Med 19(10):604–613. https://​doi.​org/​10.​1016/​j.​molmed.​2013.​08.​001 CrossRefPubMed

go back to reference Leibowitz SM, Yan J (2016) NF-κB pathways in the pathogenesis of multiple sclerosis and the therapeutic implications. Front Mol Neurosci 9:84. https://doi.org/10.3389/fnmol.2016.00084 CrossRefPubMedPubMedCentral Leibowitz SM, Yan J (2016) NF-κB pathways in the pathogenesis of multiple sclerosis and the therapeutic implications. Front Mol Neurosci 9:84. https://​doi.​org/​10.​3389/​fnmol.​2016.​00084 CrossRefPubMedPubMedCentral

go back to reference Peng H, Guerau-de-Arellano M, Mehta VB, Yang Y, Huss DJ, Papenfuss TL, Lovett-Racke AE, Racke MK (2012) Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor kappaB (NF-kappaB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem 287(33):28017–28026. https://doi.org/10.1074/jbc.M112.383380 CrossRefPubMedPubMedCentral Peng H, Guerau-de-Arellano M, Mehta VB, Yang Y, Huss DJ, Papenfuss TL, Lovett-Racke AE, Racke MK (2012) Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor kappaB (NF-kappaB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem 287(33):28017–28026. https://​doi.​org/​10.​1074/​jbc.​M112.​383380 CrossRefPubMedPubMedCentral

go back to reference Dyment DA, Herrera BM, Cader MZ, Willer CJ, Lincoln MR, Sadovnick AD, Risch N, Ebers GC (2005) Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet 14(14):2019–2026. https://doi.org/10.1093/hmg/ddi206 CrossRefPubMed Dyment DA, Herrera BM, Cader MZ, Willer CJ, Lincoln MR, Sadovnick AD, Risch N, Ebers GC (2005) Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. Hum Mol Genet 14(14):2019–2026. https://​doi.​org/​10.​1093/​hmg/​ddi206 CrossRefPubMed

go back to reference Kouri I, Papakonstantinou S, Bempes V, Vasiliadis HS, Kyritsis AP, Pelidou SH (2011) HLA associations with multiple sclerosis in Greece. J Neurol Sci 308(1–2):28–31. https://doi.org/10.1016/j.jns.2011.06.037 CrossRefPubMed Kouri I, Papakonstantinou S, Bempes V, Vasiliadis HS, Kyritsis AP, Pelidou SH (2011) HLA associations with multiple sclerosis in Greece. J Neurol Sci 308(1–2):28–31. https://​doi.​org/​10.​1016/​j.​jns.​2011.​06.​037 CrossRefPubMed

go back to reference Dardiotis E, Arseniou S, Sokratous M, Tsouris Z, Siokas V, Mentis AA, Michalopoulou A, Andravizou A, Dastamani M, Paterakis K, Bogdanos D, Brotis A (2017) Vitamin B12, folate, and homocysteine levels and multiple sclerosis: a meta-analysis. Multiple sclerosis and related disorders 17:190–197. https://doi.org/10.1016/j.msard.2017.08.004 CrossRefPubMed Dardiotis E, Arseniou S, Sokratous M, Tsouris Z, Siokas V, Mentis AA, Michalopoulou A, Andravizou A, Dastamani M, Paterakis K, Bogdanos D, Brotis A (2017) Vitamin B12, folate, and homocysteine levels and multiple sclerosis: a meta-analysis. Multiple sclerosis and related disorders 17:190–197. https://​doi.​org/​10.​1016/​j.​msard.​2017.​08.​004 CrossRefPubMed

go back to reference Mentis AA, Dardiotis E, Grigoriadis N, Petinaki E, Hadjigeorgiou GM (2017) Viruses and endogenous retroviruses in multiple sclerosis: from correlation to causation. Acta Neurol Scand 136(6):606–616. https://doi.org/10.1111/ane.12775 CrossRefPubMed Mentis AA, Dardiotis E, Grigoriadis N, Petinaki E, Hadjigeorgiou GM (2017) Viruses and endogenous retroviruses in multiple sclerosis: from correlation to causation. Acta Neurol Scand 136(6):606–616. https://​doi.​org/​10.​1111/​ane.​12775 CrossRefPubMed