Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Neurological Sciences
Published in: Neurological Sciences 12/2014

01-12-2014 | Original Article

Sleep disturbance and cognitive disorder: epidemiological analysis in a cohort of 263 patients

Authors: Michele Pistacchi, Manuela Gioulis, Franco Contin, Flavio Sanson, Sandro Zambito Marsala

Published in: Neurological Sciences | Issue 12/2014

Login to get access

Abstract

The aim of this study was to investigate and describe frequency and characteristics of sleep disorders in a large cohort of community dwelling persons with several degrees and typologies of cognitive disorders. 236 patients (78 men and 158 women) were enrolled with different subtypes of dementia: Alzheimer’s disease (AD), vascular dementia (VaD), mixed dementia, mild cognitive impairment (MCI), dementia with Lewy bodies (DLB), parkinson’s disease dementia (PDD), and frontotemporal lobar degeneration (FTLD), respectively. The sleep disturbances evaluated were: insomnia, excessive daytime sleepiness (EDS), REM behavior disorder (RBD), restless legs syndrome (RLS), and nightmares. Every type of sleep disorder was present in each type of dementia but with significant differences. Insomnia is found to be more present and specific for AD; EDS was associated with the presence of dementia in the elderly with LBD or PDD; RLS and nightmares that were recognized mainly in FTD, LBD, and PDD patients scores; patients with MCI had a frequency of sleep disturbances of any type equal to that of patients with AD presenting mostly insomnia, nightmares or RLS more frequently; nightmares were more frequent among LBD and PDD patients. Frequency of RDB was more frequent in FTD, AD, and VaD. Our findings demonstrate that sleep disturbance was related to dementia. A careful clinical evaluation of sleep disorders should be performed routinely in the clinical setting of persons with cognitive decline.
Literature
1.
Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV (2004) Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 27:1255–1273PubMed
2.
Vitiello MV (1997) Sleep disorders and aging: understanding the causes. J Gerontol A Biol Sci Med Sci 52:M189–M191PubMedCrossRef
3.
Ancoli-Israel S, Ayalon L (2006) Diagnosis and treatment of sleep disorders in older adults. Am J Geriatr Psychiatry 14:95–103PubMedCrossRef
4.
5.
6.
Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG (1995) Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep 18:425–432PubMed
7.
Bliwise DL (1996) Is sleep apnea a cause of reversible dementia in old age? J Am Geriatr Soc 44:1407–1409PubMed
8.
Redline S, Strauss ME, Adams N, Winters M, Roebuck T, Spry K et al (1997) Neuropsychological function in mild sleep-disordered breathing. Sleep 20:160–167PubMed
9.
Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O (1991) Sleep-disordered breathing in community-dwelling elderly. Sleep 14:486–495PubMedCentralPubMed
10.
Décary A, Rouleau I, Montplaisir J (2000) Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery. Sleep 23:369–381PubMed
11.
Merlino G, Piani A, Gigli GL et al (2010) Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study. Sleep Med 11:372–377PubMedCrossRef
12.
Nebes RD, Buysse DJ, Halligan EM, Houck PR, Monk TH (2009) Self-reported sleep quality predicts poor cognitive performance in healthy older adults. J Gerontol B Psychol Sci Soc Sci 64:180–187PubMedCrossRef
13.
Ohayon MM, Vecchierini MF (2002) Daytime sleepiness and cognitive impairment in the elderly population. Arch Intern Med 162:201–208PubMedCrossRef
14.
Schmutte T, Harris S, Levin R, Zweig R, Katz M, Lipton R (2007) The relation between cognitive functioning and self-reported sleep complaints in nondemented older adults: results from the Bronx aging study. Behav Sleep Med 5:39–56PubMedCrossRef
15.
16.
Vitiello MV, Borson S (2001) Sleep disturbances in patients with Alzheimer’s disease: epidemiology, pathophysiology and treatment. CNS Drugs 15:777–796PubMedCrossRef
17.
18.
Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE (2001) Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Movement Disord 16:622630CrossRef
19.
Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R et al (2001) Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry 58:353–360PubMedCrossRef
20.
Grace JB, Walker MP, McKeith IG (2000) A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer disease. Int J Geriatr Psychiatry 15:1028–1033PubMedCrossRef
21.
Bracco L, Piccini C, Moretti M, Mascalchi M, Sforza A, Nacmias B, Cellini E, Bagnoli S, Sorbi S (2005) Alzheimer’s disease: role of size and location of white matter changes in determining cognitive deficits. Dement Geriatr Cogn Disord 20:358–366PubMedCrossRef
22.
Peters F, Perani D, Herholz K, Holthoff V, Beuthien-Baumann B, Sorbi S, Pupi A, Degueldre C, Lemaire C, Collette F, Salmon E (2006) Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dement Geriatr Cogn Disord 21(5–6):373–379PubMedCrossRef
23.
International Classification of Sleep Disorders (2005) Diagnostic and coding manual, 2nd edn. American Academy of Sleep Medicine, Westchester
24.
Pollak P, Perlick D (1991) Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol 4:204–210PubMedCrossRef
25.
26.
American Psychiatric Association: DSM IVTR (2000) Diagnostic and Statistical Manual of Mental Disorders, ed 4, text revision
27.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34:939944CrossRef
28.
Romàn GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH et al (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43:250–260PubMedCrossRef
29.
McKeith IG (2006) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. J Alzheimers Dis 9(3 suppl):417–423PubMed
30.
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund L-O et al (2004) Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256:240–246PubMedCrossRef
31.
Katz S, Ford AB, Moskowitz RW et al (1963) Studies of illness in the aged: the index of ADL: a standardized measure of biological and psychosocial function. JAMA 185:914–919PubMedCrossRef
32.
Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9:179–186PubMedCrossRef
33.
Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198PubMedCrossRef
34.
Yesavage JA, Brink TL, Rose TL et al (1982–1983) Development and validation of a geriatric screening scale: a preliminary report. J Psychiatr Res 17(1):37–49CrossRef
35.
Rinaldi R, Vignatelli L, D’Alessandro R, Bassein L, Sforza E, Plazzi G et al (2001) Validation of symptoms related to excessive daytime sleepiness. Neuroepidemiology 20:248–256PubMedCrossRef
36.
Vignatelli L, Plazzi G, Barbato A et al (2003) Italian version of the Epworth sleepiness scale: external validity. Neurological Sci 23:295–300CrossRef
37.
Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health, International Restless Legs Syndrome Study Group: restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101–119PubMedCrossRef
38.
Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K (2000) Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in Augsburg elderly. Neurology 54:1064–1068PubMedCrossRef
39.
Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome Diagnosis and Epidemiology Workshop at the National Institutes of Health, International Restless Legs Syndrome Study Group: restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101–119PubMedCrossRef
40.
Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K (2000) Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in Augsburg elderly. Neurology 54:1064–1068PubMedCrossRef
41.
Bradley MD, Boeve F (2010) REM sleep behavior disorder: updated review of the core features, the RBD-Neurodegenerative Disease Association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 1184:15–54CrossRef
42.
Terzano MG, Parrino L, Cirignotta F et al (2004) Studio morfeo: insomnia in primary care, a survey conducted on the Italian population. Sleep Med 5:67–75PubMedCrossRef
43.
Foley DJ, Monjan AA, Masaki KH, Enright PL, Quan SF, White LR (1999) Associations of symptoms of sleep apnea with cardiovascular disease, cognitive impairment, and mortality among older Japanese-American men. J Am Geriatr Soc 47:524–528PubMed
44.
Foley D, Monjan A, Masaki K, Ross W, Havlik R, White L et al (2001) Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men. J Am Geriatr Soc 49:1628–1632PubMedCrossRef
45.
46.
Boeve BF, Dickson DW, Olson EJ et al (2007) Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Sleep Med 8:60–64PubMedCentralPubMedCrossRef
47.
Britton TC, Chaudhuri KR (2009) REM sleep behavior disorder and the risk of developing Parkinson disease or dementia. Neurology 72:1294–1295PubMedCrossRef
48.
Calzetti S, Negrotti A, Bonavina G, Angelini M, Marchesi E (2009) Absence of co-morbidity of parkinson disease and restless legs syndrome: a case-control study in patients attending a movement disorders clinic. Neurol Sci 30:119–122PubMedCrossRef
49.
Lee JE, Shin H-W, Kim KS, Sohn YH (2009) Factors contributing to the development of restlesslegs syndrome in patients with Parkinson. Mov Disord 24(4):579–582
Metadata
Title
Sleep disturbance and cognitive disorder: epidemiological analysis in a cohort of 263 patients
Authors
Michele Pistacchi
Manuela Gioulis
Franco Contin
Flavio Sanson
Sandro Zambito Marsala
Publication date
01-12-2014
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 12/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-014-1870-x

Other articles of this Issue 12/2014

Neurological Sciences 12/2014 Go to the issue

Review Article

Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis

Original Article

Decreased antioxidant status in migraine patients with brain white matter hyperintensities

Original Article

Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson’s disease

Original Article

Association between angiotensin converting enzyme gene insertion/deletion polymorphism and intracerebral haemorrhage in North Indian population: a case control study and meta-analysis

Review Article

Some cross-talks between immune cells and epilepsy should not be forgotten

Original Article

Vitamin D receptor polymorphisms and susceptibility to Parkinson’s disease and Alzheimer’s disease: a meta-analysis