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01-12-2014 | Original Article

Association between angiotensin converting enzyme gene insertion/deletion polymorphism and intracerebral haemorrhage in North Indian population: a case control study and meta-analysis

Authors: A. Kumar, K. Prasad, S. Vivekanandhan, A. Srivastava, S. Goswami, M. V. P. Srivastava, M. Tripathi

Published in: Neurological Sciences | Issue 12/2014

Abstract

The purpose of this study was to determine the relationship between Angiotensin converting enzyme (ACE) insertion/deletion polymorphism and ICH with an ACE level in a North Indian population. Patient with ICH and age- and sex- matched control subjects were recruited. Case control study design was used. Genotyping was performed by using Polymerase chain reaction. Serum ACE levels were measured by colorimetric method. Our results were integrated with other reported studies across different countries in a meta-analysis. One hundred and six patients with ICH and 106 age- and sex- matched control subjects were recruited. Mean age of cases and control subjects were 53.4 ± 1 and 52.9 ± 13.4, respectively. The DD genotypes were more frequency distributed in cases compared with controls (OR 2; 95 % CI, 1.02–3.8, P = 0.04) under a recessive model of inheritance. Meta-analysis suggests significant association between ACE I/D polymorphism and risk of ICH (OR 1.98; 95 % CI, 1.53–2.57) under the recessive model of inheritance and under the dominant model of inheritance (OR 1.31; 95 % CI, 1.18–1.45). The findings of the present study show a significant association between ACE insertion/deletion polymorphism and ICH. Meta-analysis indicate that ACE I/D polymorphism may be a susceptible marker for risk factor of ICH in Asian population.

Strong K, Mathers C, Bonita R (2007) Preventing stroke: saving lives around the world. Lancet Neurol 6(2):182–187PubMedCrossRef

Feigin VL, Lawes CMM, Bennett DA, Barker-Collo SL, Parag V (2009) Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol 8(4):355–369PubMedCrossRef

Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G et al (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 85(24):9386–9390PubMedCentralPubMedCrossRef

Rigat B, Hubert C, Corvol P, Soubrier F (1992) PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 20(6):1433PubMedCentralPubMedCrossRef

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86(4):1343–1346PubMedCentralPubMedCrossRef

Agerholm-Larsen B, Nordestgaard BG, Tybjaerg-Hansen A (2000) ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler Thromb Vasc Biol 20(2):484–492PubMedCrossRef

Chen Y, Dong S, He M, Qi T, Zhu W (2013) Angiotensin-converting enzyme insertion/deletion polymorphism and risk of myocardial infarction in an updated meta-analysis based on 34993 participants. Gene 522(2):196–205PubMedCrossRef

Ramachandran V, Ismail P, Stanslas J, Shamsudin N, Moin S, Jas RM (2008) Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. J Renin Angiotensin Aldosterone Syst 9(4):208–214PubMedCrossRef

Li X, Li Y, Jia N, Guo S, Chu S, Niu W (2012) Angiotensin-converting enzyme gene deletion allele increases the risk of left ventricular hypertrophy: evidence from a meta-analysis. Mol Biol Rep 39(12):10063–10075PubMedCrossRef

10.

Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S et al (2008) Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer’s disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 34(2):181–193PubMedCrossRef

11.

Lee YH, Choi SJ, Ji JD, Song GG (2012) Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis. J Renin Angiotensin Aldosterone Syst 13(1):196–201PubMedCrossRef

12.

Qin H, Zhang L, Xu G, Pan X (2013) Association of angiotensin-converting enzyme insertion/deletion polymorphism (rs4646994) with the risk of primary intracerebral hemorrhage. Neurol Res 35(6):545–552PubMedCrossRef

13.

Aho K, Harmsen P, Hatano S, Marquardsen J, Smirnov VE, Strasser T (1980) Cerebrovascular disease in the community: results of a WHO collaborative study. Bull World Health Organ 58(1):113–130PubMedCentralPubMed

14.

Kumar A, Vivekanandhan S, Srivastava A, Tripathi M, Padma Srivastava MV, Saini N et al. (2014) Association between angiotensin converting enzyme gene insertion/deletion polymorphism and ischemic stroke in north Indian population: a case-control study and meta-analysis. Neurol Res [Epub ahead of print]

15.

Kumar A, Sagar R, Kumar P, Sahu JK, Grover A, Srivastava AK et al (2013) Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design (Study protocol). BMC Neurol 13(1):136PubMedCentralPubMedCrossRef

16.

Kalita J, Somarajan BI, Kumar B, Mittal B, Misra UK (2011) A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke. Clin Chim Acta 412(7–8):642–646PubMedCrossRef

17.

Chiang FT, Hsu KL, Chen WM, Tseng CD, Tseng YZ (1998) Determination of angiotensin-converting enzyme gene polymorphisms: stepdown PCR increases detection of heterozygotes. Clin Chem 44(6 Pt 1):1353–1356PubMed

18.

Nirmal S, Tripathi M, Shastri SS, Sagar R, S V (2011) Association of Angiotensin-converting enzyme insertion(I)/deletion (D) genotype in Alzheimer’s disease patients of north Indian population. Int J Neurosci 121(10):557–561PubMedCrossRef

19.

Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F et al (1992) Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 51(1):197–205PubMedCentralPubMed

20.

Pitt B (1994) Angiotensin-converting enzyme inhibitors in patients with coronary atherosclerosis. Am Heart J 128(6 Pt 2):1328–1332PubMedCrossRef

21.

Villard E, Soubrier F (1996) Molecular biology and genetics of the angiotensin-I-converting enzyme: potential implications in cardiovascular diseases. Cardiovasc Res 32(6):999–1007PubMedCrossRef

22.

Moncada R, Pulmer R, Higgs E (1995) Generation of prostacyclin and endothelium derived relaxing factor from endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 92:1137–1141CrossRef

23.

Nawaz SK, Hasnain S (2011) Effect of ACE polymorphisms on the association between noise and hypertension in a Pakistani population. J Renin Angiotensin Aldosterone Syst 12(4):516–520PubMedCrossRef

24.

Jeng JR, Harn HJ, Jeng CY, Yueh KC, Shieh SM (1997) Angiotensin I converting enzyme gene polymorphism in Chinese patients with hypertension. Am J Hypertens 10(5 Pt 1):558–561PubMedCrossRef

25.

Zhu M, Zhang J, Nie S, Yan W (2012) Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis. J Assist Reprod Genet 29(9):921–932PubMedCentralPubMedCrossRef

26.

Dardiotis E, Jagiella J, Xiromerisiou G, Dardioti M, Vogiatzi C, Urbanik A et al (2011) Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage. Pharmacogenet Genomics 21(3):136–141PubMedCrossRef

27.

Higashimori K, Zhao Y, Higaki J, Kamitani A, Katsuya T, Nakura J et al (1993) Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem Biophys Res Commun 191(2):399–404PubMedCrossRef

28.

Vassilikioti S, Doumas M, Douma S, Petidis K, Karagiannis A, Balaska K et al (1996) Angiotensin converting enzyme gene polymorphism is not related to essential hypertension in a Greek population. Am J Hypertens 9(7):700–702PubMedCrossRef

29.

Chiang FT, Lai ZP, Chern TH, Tseng CD, Hsu KL, Lo HM et al (1997) Lack of association of the angiotensin converting enzyme polymorphism with essential hypertension in a Chinese population. Am J Hypertens 10(2):197–201PubMedCrossRef

30.

Samarasekera N, Smith C, Al-Shahi SR (2012) The association between cerebral amyloid angiopathy and intracerebral haemorrhage: systematic review and meta-analysis. J Neurol Neurosurg Psychiatr 83(3):275–281PubMedCrossRef

31.

Cohen BA, Biller J (1992) Hemorrhagic stroke due to cerebral vasculitis and the role of immunosuppressive therapy. Neurosurg Clin N Am 3(3):611–624PubMed

32.

Song GG, Kim J-H, Lee YH (2013) Associations between the insertion/deletion polymorphism of the angiotensin-converting enzyme and susceptibility to aortic aneurysms: a meta-analysis. J Renin Angiotensin Aldosterone Syst [Epub ahead of print]

33.

Misra UK, Kalita J, Somarajan BI, Kumar B, Das M, Mittal B (2012) Do ACE (rs4646994) and αADDUCIN (rs4961) gene polymorphisms predict the recurrence of hypertensive intracerebral hemorrhage? Neurol Sci 33(5):1071–1077PubMedCrossRef

34.

Kalita J, Misra UK, Bindu IS, Kumar B, Mittal B (2011) Angiotensin-converting enzyme (rs4646994) and α ADDUCIN (rs4961) gene polymorphisms’ study in primary spontaneous intracerebral hemorrhage. Neurol India 59(1):41–46PubMedCrossRef

35.

Huang Y, Li G, Lan H, Zhao G, Huang C (2014) Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies. J Renin Angiotensin Aldosterone Syst 15(1):32–38

36.

Slowik A, Turaj W, Dziedzic T, Haefele A, Pera J, Malecki MT et al (2004) DD genotype of ACE gene is a risk factor for intracerebral hemorrhage. Neurology 63(2):359–361PubMedCrossRef

37.

Sun Y, Liu Y, Watts LT, Sun Q, Zhong Z, Yang G-Y et al (2013) Genetic associations of angiotensin-converting enzyme with primary intracerebral hemorrhage: a meta-analysis. PLoS One 8(6):e67402PubMedCentralPubMedCrossRef

Title: Association between angiotensin converting enzyme gene insertion/deletion polymorphism and intracerebral haemorrhage in North Indian population: a case control study and meta-analysis
Authors: A. Kumar
K. Prasad
S. Vivekanandhan
A. Srivastava
S. Goswami
M. V. P. Srivastava
M. Tripathi
Publication date: 01-12-2014
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 12/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1877-3

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Association between angiotensin converting enzyme gene insertion/deletion polymorphism and intracerebral haemorrhage in North Indian population: a case control study and meta-analysis

Abstract

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Abstract

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