Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Neurological Sciences
Published in: Neurological Sciences 8/2013

01-08-2013 | Original Article

Cutaneous allodynia in patients with episodic migraine

Authors: Hayat Güven, Aslı Ece Çilliler, Selim Selçuk Çomoğlu

Published in: Neurological Sciences | Issue 8/2013

Login to get access

Abstract

Cutaneous allodynia may be observed in patients with migraine and this reflects the central sensitization of the trigeminal neurons. We aimed to investigate the frequency of cutaneous allodynia in patients with episodic migraine and to compare clinical characteristics of migraine patients with and without allodynia. One hundred and eighty-six consecutive patients with episodic migraine attacks were prospectively included in the study. The cutaneous allodynia symptoms that occurred during headache attacks were documented using a questionnaire for assessing cephalic and extracephalic cutaneous allodynia. One hundred and fourteen patients (61.3 %) were observed to develop allodynia during migraine attacks and the ratio of the female gender was found higher among the patients with allodynia (p < 0.001). Migraine disease duration was longer (p = 0.004) and accompanying nausea and phonophobia were more common (p = 0.003 and p = 0.005, respectively) in the patients with allodynia. Menstrually related migraine was found to be associated with both allodynia (p = 0.049) and its severity (p = 0.003). The results of present study revealed that cutaneous allodynia was rather frequent in episodic migraine, particularly in patients having longer disease duration. Higher frequency of allodynia in women and its association with menstrually related migraine may be related to the effects of hormonal factors on cutaneous pain thresholds and central sensitization. Association of nausea and phonophobia with allodynia may be interpreted as the common pathways are shared in the development of these symptoms.
Literature
1.
2.
Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF; American Migraine Prevalence Prevention Advisory Group (2008) Cutaneous allodynia in the migraine population. Ann Neurol 63(2):148–158CrossRef
3.
Lovati C, D’Amico D, Rosa S, Suardelli M, Mailland E, Bertora P, Pomati S, Mariani C, Bussone G (2007) Allodynia in different forms of migraine. Neurol Sci 28(Suppl 2):S220–S221PubMedCrossRef
4.
LoPinto C, Young WB, Ashkenazi A (2006) Comparison of dynamic (brush) and static (pressure) mechanical allodynia in migraine. Cephalalgia 26(7):852–856PubMedCrossRef
5.
Bigal ME, Ashina S, Burstein R, Reed ML, Buse D, Serrano D, Lipton RB; AMPP Group (2008) Prevalence and characteristics of allodynia in headache sufferers: a population study. Neurology 70(17):1525–1533CrossRef
6.
Lovati C, D’Amico D, Bertora P (2009) Allodynia in migraine: frequent random association or unavoidable consequence? Expert Rev Neurother 9(3):395–408PubMedCrossRef
7.
Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA (2009) Allodynia in migraine: associated with comorbid pain conditions. Headache 49(9):1333–1344PubMedCrossRef
8.
Lovati C, D’Amico D, Bertora P, Raimondi E, Rosa S, Zardoni M, Bussone G, Mariani C (2010) Correlation between presence of allodynia and sleep quality in migraineurs. Neurol Sci 31(Suppl 1):S155–S158PubMedCrossRef
9.
d’Agostino VC, Francia E, Licursi V, Cerbo R (2010) Clinical and personality features of allodynic migraine. Neurol Sci 31(1):S159–S161PubMedCrossRef
10.
Lovati C, D’Amico D, Bertora P, Rosa S, Suardelli M, Mailland E, Mariani C, Bussone G (2008) Acute and interictal allodynia in patients with different headache forms: an Italian pilot study. Headache 48(2):272–277PubMedCrossRef
11.
Jakubowski M, Silberstein S, Ashkenazi A, Burstein R (2005) Can allodynic migraine patients be identified interictally using a questionnaire? Neurology 65(9):1419–1422PubMedCrossRef
12.
Ashkenazi A, Sholtzow M, Shaw JW, Burstein R, Young WB (2007) Identifying cutaneous allodynia in chronic migraine using a practical clinical method. Cephalalgia 27(2):111–117PubMedCrossRef
13.
Mathew NT, Kailasam J, Seifert T (2004) Clinical recognition of allodynia in migraine. Neurology 63(5):848–852PubMedCrossRef
14.
Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH (2000) An association between migraine and cutaneous allodynia. Ann Neurol 47(5):614–624PubMedCrossRef
15.
Guy N, Marques AR, Orliaguet T, Lanteri-Minet M, Dallel R, Clavelou P (2010) Are there differences between cephalic and extracephalic cutaneous allodynia in migraine patients? Cephalalgia 30(7):881–886PubMed
16.
Schürks M, Diener HC (2008) Migraine, allodynia, and implications for treatment. Eur J Neurol 15(12):1279–1285PubMedCrossRef
17.
Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D (2010) Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol 68(1):81–91PubMedCrossRef
18.
Landy S, Rice K, Lobo B (2004) Central sensitisation and cutaneous allodynia in migraine: implications for treatment. CNS Drugs 18(6):337–342PubMedCrossRef
19.
Goadsby PJ (2007) Recent advances in understanding migraine mechanisms, molecules and therapeutics. Trends Mol Med 13(1):39–44PubMedCrossRef
20.
21.
Aurora SK, Kulthia A, Barrodale PM (2011) Mechanism of chronic migraine. Curr Pain Headache Rep 15(1):57–63PubMedCrossRef
22.
Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioramanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F (2009) Medullary pain facilitating neurons mediate allodynia in headache-related pain. Ann Neurol 65(2):184–193PubMedCrossRef
23.
Burstein R (2009) Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia–but is it the same in migraine with established allodynia? Headache 49(3):364–365PubMedCrossRef
24.
Burstein R, Jakubowski M (2010) Managing migraine associated with sensitization. Handb Clin Neurol 97:207–215PubMedCrossRef
25.
Headache Classification Subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders: 2nd edition. Cephalalgia 24(Suppl 1):9–160
26.
Young WB, Richardson ES, Shukla P (2005) Brush allodynia in hospitalized headache patients. Headache 45(8):999–1003PubMedCrossRef
27.
Ashkenazi A, Silberstein S, Jakubowski M, Burstein R (2007) Improved identification of allodynic migraine patients using a questionnaire. Cephalalgia 27(4):325–329PubMedCrossRef
28.
Gazerani P, Andersen OK, Arendt-Nielsen L (2005) A human experimental capsaicin model for trigeminal sensitization. gender-specific differences. Pain 118(1–2):155–163
29.
Palmeira CC, Ashmawi HA, Posso Ide P (2011) Sex and pain perception and analgesia. Rev Bras Anestesiol 61(6):814–828PubMedCrossRef
30.
Matos R, Wang K, Jensen JD, Jensen T, Neuman B, Svensson P, Arendt-Nielsen L (2011) Quantitative sensory testing in the trigeminal regions: site and gender differences. J Orofac Pain 25(2):161–169PubMed
31.
Aguggia M, Saracco MG (2010) Pathophysiology of migraine chronification. Neurol Sci 31(Suppl 1):S15–S17PubMedCrossRef
32.
Kelman L, Tanis D (2006) The relationship between migraine pain and other associated symptoms. Cephalalgia 26(5):548–553PubMedCrossRef
33.
Ruggiero DA, Underwood MD, Mann JJ, Anwar M, Arango V (2000) The human nucleus of the solitary tract: visceral pathways revealed with an “in vitro” postmortem tracing method. J Auton Nerv Syst 79(2–3):181–190PubMedCrossRef
34.
Ashkenazi A, Yang I, Mushtag A, Oshinsky ML (2010) Is phonophobia associated with cutaneous allodynia in migraine? J Neurol Neurosurg Psychiatry 81(11):1256–1260PubMedCrossRef
35.
Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8(2):136–142PubMedCrossRef
Metadata
Title
Cutaneous allodynia in patients with episodic migraine
Authors
Hayat Güven
Aslı Ece Çilliler
Selim Selçuk Çomoğlu
Publication date
01-08-2013
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 8/2013
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-012-1249-9

Other articles of this Issue 8/2013

Neurological Sciences 8/2013 Go to the issue

Original Article

Understanding quantitative and qualitative figural fluency in patients with Parkinson’s disease

Original Article

Association of monocyte chemoattractant protein-1 −2518A>G polymorphism with occurrence, severity, and outcome in ischemic stroke

Letter to the Editor

Eyelid nystagmus and primary position upbeat nystagmus

Original Article

White matter hyperintensities and quality of life in acute lacunar stroke

Letter to the Editor

Aseptic meningitis in Kikuchi’s disease mimicking tuberculous meningitis

Original Article

The expression of Toll-like receptors in murine Müller cells, the glial cells in retina